Simultaneous Measurement and Integrated Analysis of Analgesia and Respiration after an Intravenous Morphine Infusion

Dahan, Albert; Romberg, Raymonda; Teppema, Luc J.; Sarton, Elise; Bijl, Hans; Olofsen, Erik

doi:10.1097/00000542-200411000-00021

Cited by 81 publications

(55 citation statements)

References 25 publications

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“…Furthermore, because the pulmonary vasculature contains mu receptors and there are documented effects of opioids on pulmonary hemodynamics, we reasoned that is important to further explore the effects of fentanyl. 10,11 Therefore, the present study was undertaken to investigate the vascular responses to fentanyl in the cat lung bed under conditions of constant flow.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Effects of Fentanyl in the Feline Pulmonary Vascular Bed

Kaye¹,

Hoover

Ibrahim³

et al. 2006

American Journal of Therapeutics

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The objective of this study was to test the hypothesis that fentanyl induces a depressor response in the pulmonary vascular bed of the cat and to identify the receptors involved in the mediation or modulation of these effects. The authors conducted a prospective vehicle-controlled study at a university research laboratory using intact chest preparation in adult mongrel cats. In separate experiments, the effects of diphenhydramine (histamine receptor blocker), glibenclamide (ATP-sensitive K+ channel blocker), L-N5-(1-Iminoethyl) ornithine hydrochloride (L-NIO) (nitric oxide synthase inhibitor), nimesulide (selective cyclooxygenase [COX]-2 inhibitor), and naloxone (opiate receptor antagonist) were investigated on pulmonary arterial responses to fentanyl and other agonists in the pulmonary vascular bed of the cat. The systemic pressure and lobar arterial perfusion pressure were continuously monitored, electronically averaged, and recorded. In the feline pulmonary vascular bed of the isolated left lower lobe, fentanyl induced a dose-dependent vasodepressor response that was not significantly altered after administration of glibenclamide, L-NIO, and nimesulide. However, the responses to fentanyl were significantly attenuated after administration of diphenhydramine and naloxone. The results of the present study suggest that fentanyl has potent vasodepressor activity in the pulmonary vascular bed of the cat and that this response may be mediated or modulated by both histaminergic and opiate receptor sensitive pathways.

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Section: Introductionmentioning

confidence: 99%

Analysis of the Effects of Fentanyl in the Feline Pulmonary Vascular Bed

Kaye¹,

Hoover

Ibrahim³

et al. 2006

American Journal of Therapeutics

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“…Previous studies have described morphine PK with two-and threecompartment models (Staahl et al, 2008;Lotsch et al, 2002;Dahan et al, 2004;Meineke et al, 2002;Mazoit et al, 2007;Ravn et al, 2014;Upton et al, 2006), but the sampling period was longer in most of these studies than in the current study. A poor PK model might lead to biased estimation of the PK-PD relationship.…”

Section: Pharmacokineticsmentioning

confidence: 74%

Modelling concentration–analgesia relationships for morphine to evaluate experimental pain models

Sverrisdóttir

Foster

Upton

et al. 2015

European Journal of Pharmaceutical Sciences

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“…29 Respiratory depression is a side effect of opioid administration and may be life threatening, especially in the postoperative period. Population analysis of depression of ventilation and of the ventilatory response to hypoxia because of morphine, morphine-6-glucuronide, and remifentanil also revealed a relatively large interindividual variability, whereas no explanatory covariates were found, [30][31][32] but the studied populations were small and/or homogeneous.…”

Section: Population Pk/pdmentioning

confidence: 93%

Population pharmacokinetics/pharmacodynamics of anesthetics

Olofsen

Dahan

2005

AAPS J

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In this article we review how population pharmacokinetic/ pharmacodynamic (PD) modeling has evolved in the specialty of anesthesiology, how anesthesiology benefited from the mixed-effects approach, and which features of modeling need careful attention. Key articles from the anesthesiology literature are selected to discuss the modeling of typical anesthesiological PD end points, such as level of consciousness and analgesia, interactions between hypnotics and analgesics, estimation with poor and sometimes rich data sets from populations of various sizes, covariate detection, covariances between random effects, and Bayesian forecasting.

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Simultaneous Measurement and Integrated Analysis of Analgesia and Respiration after an Intravenous Morphine Infusion

Cited by 81 publications

References 25 publications

Analysis of the Effects of Fentanyl in the Feline Pulmonary Vascular Bed

Analysis of the Effects of Fentanyl in the Feline Pulmonary Vascular Bed

Modelling concentration–analgesia relationships for morphine to evaluate experimental pain models

Population pharmacokinetics/pharmacodynamics of anesthetics

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