Simultaneous Near‐Infrared and Two‐Photon In Vivo Imaging of H<sub>2</sub>O<sub>2</sub> Using a Ratiometric Fluorescent Probe based on the Unique Oxidative Rearrangement of Oxonium

Dong, Baoli; Song, Xuezhen; Kong, Xiuqi; Wang, Chao; Tang, Yonghe; Liu, Yong; Lin, Weiying

doi:10.1002/adma.201602939

Cited by 201 publications

(77 citation statements)

References 40 publications

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“…Two‐photon absorption (TPA) materials that can be excited by near‐infrared (NIR) light (700–1100 nm) have decreased photobleaching effects, minimal photodamage of cellular structures, low background interference, and long penetration depth (>500 nm) 6. Thus, two‐photon microscopy becomes an attractive tool to visualize biological events within live cells and intact tissues.…”

Section: Introductionmentioning

confidence: 99%

Delivery of Phosphorescent Anticancer Iridium(III) Complexes by Polydopamine Nanoparticles for Targeted Combined Photothermal‐Chemotherapy and Thermal/Photoacoustic/Lifetime Imaging

et al. 2018

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Recently, phosphorescent iridium complexes have demonstrated great potential as anticancer and imaging agents. Dopamine is a melanin‐like mimic of mussel adhesive protein that can self‐polymerize to form polydopamine (PDA) nanoparticles that demonstrate favorable biocompatibility, near‐infrared absorption, and photothermal effects. Herein, PDA nanoparticles are functionalized with β‐cyclodextrin (CD) substitutions, which are further assembled with adamantane‐modified arginine‐glycine‐aspartic acid (Ad‐RGD) tripeptides to target integrin‐rich tumor cells. The thus formed PDA‐CD‐RGD nanoparticles can deliver a phosphorescent iridium(III) complexes LysoIr ([Ir(ppy)2(l)]PF6, ppy = 2‐phenylpyridine, L = (1‐(2‐quinolinyl)‐β‐carboline) to form a theranostic platform LysoIr@PDA‐CD‐RGD. It is demonstrated that LysoIr@PDA‐CD‐RGD can be applied for targeted combined cancer photothermal‐chemotherapy and thermal/photoacoustic/two‐photon phosphorescence lifetime imaging under both in vitro and in vivo conditions. This work provides a useful strategy to construct multifunctional nanocomposites for the optimization of metal‐based anticancer agents for further biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Delivery of Phosphorescent Anticancer Iridium(III) Complexes by Polydopamine Nanoparticles for Targeted Combined Photothermal‐Chemotherapy and Thermal/Photoacoustic/Lifetime Imaging

et al. 2018

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“…The NIR‐II emission of NIR‐I dyes could be important to further improve fluorescence‐guided surgery with significantly reduced tissue autofluorescence and scattering, and the systematic investigation of bioconjugatable NIR‐I/II dyes will further enrich this field. Although optically guided surgery has been achieved in the NIR‐I region with several successful surgical navigation systems, it is still critically important to further improve the detection depth, signal contrast, and sensitivity . This improvement will yield a comprehensive fluorescence‐guided platform with adjustable imaging speed (real‐time) and contrast (S/B ratio), and multitargeted imaging for visualizing complex diseases simultaneously.…”

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confidence: 99%

Repurposing Cyanine NIR‐I Dyes Accelerates Clinical Translation of Near‐Infrared‐II (NIR‐II) Bioimaging

et al. 2018

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The significantly reduced tissue autofluorescence and scattering in the NIR-II region (1000-1700 nm) opens many exciting avenues for detailed investigation of biological processes in vivo. However, the existing NIR-II fluorescent agents, including many molecular dyes and inorganic nanomaterials, are primarily focused on complicated synthesis routes and unknown immunogenic responses with limited potential for clinical translation. Herein, the >1000 nm tail emission of conventional biocompatible NIR cyanine dyes with emission peaks at 700-900 nm is systematically investigated, and a type of bright dye for NIR-II imaging with high potential for accelerating clinical translation is identified. The asymmetry of the π domain in the S state of NIR cyanine dyes is proven to result in a twisted intramolecular charge-transfer process and NIR-II emission, establishing a general rule to guide future NIR-I/II fluorophore synthesis. The screened NIR dyes are identified to possess a bright emission tail in the NIR-II region along with high quantum yield, high molar-extinction coefficient, rapid fecal excretion, and functional groups amenable for bioconjugation. As a result, NIR cyanine dyes can be used for NIR-II imaging to afford superior contrast and real-time imaging of several biological models, facilitating the translation of NIR-II bioimaging to clinical theranostic applications.

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“…In‐contrast, the fluorescent probes with absorption and emission in far‐red to NIR region are favorable for bioimaging because of deep tissue penetration, minimum photo damage to biological samples, minimum interference from background autofluorescence by biomolecules in the living systems. . Hence, NIR fluorophores have emerged as promising modalities in monitoring in‐vitro and in‐vivo levels of several biologically important species .…”

Section: Introductionmentioning

confidence: 99%

Towards NIR‐Active Hydroxybenzazole (HBX)‐Based ESIPT Motifs: A Recent Research Trend

2020

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In this review, we have explored the synthetic strategies adopted for designing the hydroxybenzazoles (imidazole, oxazole, and thiazole) i. e. HBX derivatives which show emission in red and NIR region. Further, we have examined the effect of different substituents i. e. either directly attached or with extended conjugation on a phenolic ring/ phenyl ring of heterocycles to achieve a red to NIR shift in emission. Finally, we have investigated the applications and computational methodologies adopted for red to NIR emitting dyes. In the future, this review will help to design, synthesized and examine the applications of new derivatives of HBX which will show emission in red to NIR region.

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Simultaneous Near‐Infrared and Two‐Photon In Vivo Imaging of H₂O₂ Using a Ratiometric Fluorescent Probe based on the Unique Oxidative Rearrangement of Oxonium

Cited by 201 publications

References 40 publications

Delivery of Phosphorescent Anticancer Iridium(III) Complexes by Polydopamine Nanoparticles for Targeted Combined Photothermal‐Chemotherapy and Thermal/Photoacoustic/Lifetime Imaging

Delivery of Phosphorescent Anticancer Iridium(III) Complexes by Polydopamine Nanoparticles for Targeted Combined Photothermal‐Chemotherapy and Thermal/Photoacoustic/Lifetime Imaging

Repurposing Cyanine NIR‐I Dyes Accelerates Clinical Translation of Near‐Infrared‐II (NIR‐II) Bioimaging

Towards NIR‐Active Hydroxybenzazole (HBX)‐Based ESIPT Motifs: A Recent Research Trend

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Simultaneous Near‐Infrared and Two‐Photon In Vivo Imaging of H2O2 Using a Ratiometric Fluorescent Probe based on the Unique Oxidative Rearrangement of Oxonium

Cited by 201 publications

References 40 publications

Delivery of Phosphorescent Anticancer Iridium(III) Complexes by Polydopamine Nanoparticles for Targeted Combined Photothermal‐Chemotherapy and Thermal/Photoacoustic/Lifetime Imaging

Delivery of Phosphorescent Anticancer Iridium(III) Complexes by Polydopamine Nanoparticles for Targeted Combined Photothermal‐Chemotherapy and Thermal/Photoacoustic/Lifetime Imaging

Repurposing Cyanine NIR‐I Dyes Accelerates Clinical Translation of Near‐Infrared‐II (NIR‐II) Bioimaging

Towards NIR‐Active Hydroxybenzazole (HBX)‐Based ESIPT Motifs: A Recent Research Trend

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Simultaneous Near‐Infrared and Two‐Photon In Vivo Imaging of H₂O₂ Using a Ratiometric Fluorescent Probe based on the Unique Oxidative Rearrangement of Oxonium