Simultaneous Spectrophotometric Estimation of Telmisartan and Amlodipine Besylate in Tablet Dosage Form

Abstract

A simple, accurate and reproducible spectrophotometric methods have been developed for the simultaneous estimation of Telmisartan (TEL) and Amlodipine Besylate (AML) in combined tablet dosage forms. The method involves determination using the simultaneous equation method, the sampling wavelengths selected are ‘TLM’ = 297nm.and ‘AML’ =238nm., over the concentration ranges of 8-48μg/ml for ‘TEL’ and 1-6 μg/ml for ‘AML’ respectively. The method was validated for linearity, accuracy, precision, robustness and application for assay as per ICH guidelines. The proposed method is simple, economical, accurate and precise, and could be successfully employed in routine quality control for the simultaneous analysis of Telmisartan (TEL) and Amlodipine Besylate (AML).

Assessment and Comparison of Greenness of UV-Spectroscopy Methods for Simultaneous Determination of Anti-Hypertensive Combination

“…The regular quality control for the simultaneous analysis of Amlodipine besylate (AML) and Telmisartan (TEL) could benefit from the use of the suggested method, which is easy to use, affordable, accurate and exact. 18 Deepali M. Gangrade and Priyanka Y. Kulkarni (2016) produced a novel approach to simultaneously determine Amlodipine besylate, telmisartan and hydrochlorothiazide in combination tablet dosage form using a UV-spectrophotometric absorption correction method that is easy to use, sensitive and accurate. For amlodipine besylate, telmisartan and hydrochlorothiazide, the chosen wavelengths for the analysis were 365 nm, 250 nm and 335 nm, respectively.…”

A Review on Simultaneous Determination of Anti-Hypertensive Drug Combinations Containing Amlodipine Besylate using Chromatographic Analysis

“…The retention time of Norvasc (Amlodipine besylate) and Telmisartan were 5.0 and 1.0min respectively. The standardization curves of concentration against peak space, which was linear from 8-48 ug/ml for Telmisartan and 1-6 ug/ml for Amlodipine besylate, had parametric statistic (r) larger than 0.999 [16] .…”

Development and Validation of Q-Absorbance Ratio Method for Simultaneous Estimation of Valsartan and Nifedipine in Synthetic Mixture

“…Literature review reveals UV Spectrophotometry 4 , HPLC 5 and HPTLC 6 methods for analysis of VAL in tablet dosage forms. Literature review also shows UV Spectrophotometry 7 , HPLC 8 and HPTLC 9 methods for determination of VAL in combination with other drugs. Nifedipine (NIF) is chemically 3, 5-Pyridinedicarboxylic acid, 1, 4-dihydro-2, 6-dimethyl-4-(2-nitophenyl)-, dimethyl ester (Figure 2), is a calcium channel blocker.…”