Síndrome do anticorpo antifosfolípide: estudo comparativo das formas primária e secundária

Freitas, Max Victor Carioca; Silva, Lucienir Maria da; Petean, Flávio Calil; Carvalho, Ivan Fiore de; Franco, Rendrik F.; Donadi, Eduardo Antônio; Júnior, Paulo Louzada

doi:10.1590/s0482-50042003000300005

Cited by 5 publications

(7 citation statements)

References 22 publications

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“…The analysis of 59 patients followed in our hospital with APS (27 primary APS and 32 with APS secondary to SLE) showed that arterial thrombosis is more prevalent in primary APS and that there were no cases of coronary involvement in this series 8 .…”

Section: Discussionmentioning

confidence: 66%

Trombose coronariana como primeira complicação da aíndrome antifosfolípide

Miranda¹,

Gali²,

Marin-Neto³

et al. 2012

Arq. Bras. Cardiol.

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Section: Discussionmentioning

confidence: 66%

Trombose coronariana como primeira complicação da aíndrome antifosfolípide

Miranda¹,

Gali²,

Marin-Neto³

et al. 2012

Arq. Bras. Cardiol.

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“…Ao se comparar os grupos de pacientes com SAF primária com aqueles que apresentam SAF secundária, a presença de tromboses arteriais é estatisticamente maior na população de SAF primária. Esse resultado corrobora estudo epidemiológico brasileiro prévio (13) . No entanto, ao serem analisados eventos trombóticos específicos, só foram encontradas diferenças significativas em isquemia de extremidades e síndrome de Sneddon, ambas mais freqüentes nos doentes com SAF primária.…”

Section: Resultsunclassified

“…Igualmente incertas são as reais diferenças entre as síndromes primária e secundária da SAF. No Brasil, há carência de estudos epidemiológicos a respeito do presente tópico (13) . Sabe-se, ainda, que existem grandes variações étnicas na expressão clínica da SAF (1,(9)(10)(11)(12)14,15) .…”

Section: Palavrasunclassified

Estudo comparativo entre a síndrome antifosfolípide primária e a secundária: características clínico-laboratoriais em 149 pacientes

Quaio

Grando

Carvalho³

2008

Rev. Bras. Reumatol.

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“…The literature reports the presence of anticardiolipin antibodies in other infectious diseases. 37 Repka et al 38 observed those antibodies in 8.34% of patients with paucibacillary leprosy and 80.77% of non-treated patients with multibacillary leprosy. The origin of anticardiolipin antibodies in patients with infections has been widely debated and several hypotheses have been suggested.…”

Section: Discussionmentioning

confidence: 95%

“…38 The presence of anticardiolipin antibodies in patients with leishmaniasis is important since those antibodies are related with the etiopathogenic mechanisms of venous and arterial thrombosis. 37 In 2006, Terrazzano et al 39 studied 33 dogs naturally infected by Leishmania infantum and observed that 63.3% of them had antiplatelet antibodies and half of those animals had thrombocytopenia and clinical signs of moderate to severe disease.…”

Section: Discussionmentioning

confidence: 99%

Frequência de autoanticorpos e dosagem de complemento sérico em pacientes com diagnóstico de leishmaniose cutânea ou visceral

Horimoto¹,

Costa²

2009

Rev. Bras. Reumatol.

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Introduction: Leishmaniasis is a chronic infectious disease whose spectrum can vary from isolate cutaneous involvement with oligosymptomatic manifestations to systemic involvement with clinically important manifestations. The development of the infection of each type of leishmaniasis (visceral or cutaneous) depends on a complex and intriguing interaction between virulence factors of the pathogen and the immune response of the host. Analysis of sera of with Leishmania infection demonstrates the presence of autoantibodies against cellular and humoral components, besides circulating immune complexes and anti-IgG antibodies (rheumatoid factor). Patients with visceral leishmaniasis can present symptoms that mimic Systemic Lupus Erythematosus (SLE), hindering early diagnosis and treatment. Objectives: To identify the profile of autoantibodies and complement levels of patients with visceral or cutaneous leishmaniasis and to correlate their clinical presentation to those of patients with SLE. Methods: The presence of autoantibodies and complement levels of 90 patients, 45 with visceral leishmaniasis and 45 with cutaneous leishmaniasis, was determined. Results: The presence of statistically significant autoantibodies in patients with visceral leishmaniasis included: antinuclear antibody (ANA), positive (4.4%) or in low titers (8.9%), and IgG anticardiolipin antibody, positive (17.8%) or undetermined (8.9%). A reduction in C3 levels was also seen in 17.8% of the patients and anti-Leishmania antibodies > 1/80 in all patients with visceral leishmaniasis. Conclusions: Visceral leishmaniasis can have a positive correlation with the presence of autoantibodies, possibly by triggering a predominantly humoral, systemic, type Th2 response, representing an obligatory differential diagnosis with SLE, especially in endemic areas.

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Síndrome do anticorpo antifosfolípide: estudo comparativo das formas primária e secundária

Cited by 5 publications

References 22 publications

Trombose coronariana como primeira complicação da aíndrome antifosfolípide

Trombose coronariana como primeira complicação da aíndrome antifosfolípide

Estudo comparativo entre a síndrome antifosfolípide primária e a secundária: características clínico-laboratoriais em 149 pacientes

Frequência de autoanticorpos e dosagem de complemento sérico em pacientes com diagnóstico de leishmaniose cutânea ou visceral

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