Single-cell directional sensing from just a few receptor binding events

Bernoff, Andrew J.; Jilkine, Alexandra; Hernández, Adrián Navarro; Lindsay, Alan E.

doi:10.1016/j.bpj.2023.06.015

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2024

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“…Even at high chemoattractant densities, eukaryotic cells adopt their direction on the time scale of the first binding events [ 24 ]. Indeed, a simple model has recently shown how the first bindings can confer enough information to accurately estimate the source direction at a close enough distance [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Memoryless chemotaxis with discrete cues

Knight,

García-Galindo,

Pausch

et al. 2024

J. R. Soc. Interface.

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Biological systems such as axonal growth cones perform chemotaxis at micrometre-level length scales, where chemotactic molecules are sparse. Such systems lie outside the range of validity of existing models, which assume smoothly varying chemical gradients. We investigate the effect of introducing discrete chemoattractant molecules by constructing a minimal dynamical model consisting of a chemotactic cell without internal memory. Significant differences are found in the behaviour of the cell as the chemical gradient is changed from smoothly varying to discrete, including the emergence of a homing radius beyond which chemotaxis is not reliably performed.

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Section: Discussionmentioning

confidence: 99%