Single-Entity Approach to Investigate Surface Charge Enhancement in Magnetoelectric Nanoparticles Induced by AC Magnetic Field Stimulation

Pandey, Popular; Ghimire, Govinda; Garcı́a, Javier; Rubfiaro, Alberto Seseña; Wang, Xuewen; Tomitaka, Asahi; Nair, M. G.; He, Jin

doi:10.1021/acssensors.0c00664

Cited by 24 publications

(13 citation statements)

References 45 publications

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“…It was performed in triplicate and shown as mean. 50,51 Drug Entrapment Efficiency Entrapment efficiency (EE) of rosuvastatin SNEDDS was examined as per the procedure established by Ke et al In brief, the content of free rosuvastatin was separated from SNEDDS by the ultrafiltration method (3500 Da) with centrifugation at 3000 g for 5 minutes followed by qualification using UV spectrophotometer at 242 nm. The EE was calculated as follows:…”

Section: Analysis Of Drug Contentmentioning

confidence: 99%

Improved Pharmacodynamic Potential of Rosuvastatin by Self-Nanoemulsifying Drug Delivery System: An in vitro and in vivo Evaluation

Verma¹,

Kaushik²,

Almeer³

et al. 2021

IJN

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The purpose of this proposed research was to investigate a nano-formulation developed using self-nanoemulsifying drug delivery system (SNEDDS) to improve the pharmacodynamic potential of rosuvastatin by assisting its transportation through lymphatic circulation. Methods: The utilized lipids, surfactants, and co-surfactants for SNEDDS were selected on the basis of solubility studies. The SNEDDS formulation was optimized by implementing a D-optimal mixture design, wherein the effect of concentration of Capmul MCM EP (X 1), Tween 20 (X 2) and Transcutol P (X 3) as independent variables was studied on droplet size (Y 1), % cumulative drug release (Y 2) and self-emulsification time (Y 3) as dependent variables. The optimized formulation was evaluated via in vitro parameters and in vivo pharmacodynamic potential in Wistar rats. Results: The D-optimal mixture design and subsequent ANOVA application resulted in the assortment of the optimized SNEDDS formulation that exhibited a droplet size of nano range (14.91nm), in vitro drug release of >90% within 30 minutes, and self-emulsification time of 16 seconds. The in vivo pharmacodynamic study carried out using Wistar rats confirmed the better antihyperlipidemic potential of developed formulation in normalizing the lipidic level of serum in contrast to pure drug and marketed tablets. Conclusion: This research reports the application of D-optimal mixture design for successful and systematic development of rosuvastatin-loaded SNEDDS with distinctly enhanced in vitro and in vivo performance in comparison to marketed formulation. Eventually, improved anti-hyperlipidemic efficacy was envisaged which might be attributed to increased drug solubility and absorption. Overall, this study shows the utility of SNEDDS for improving the dissolution rate and bioavailability of poor aqueous-soluble drugs. The present SNEDDS formulation could be a promising approach and alternative to conventional dosage form.

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Section: Analysis Of Drug Contentmentioning

confidence: 99%

Improved Pharmacodynamic Potential of Rosuvastatin by Self-Nanoemulsifying Drug Delivery System: An in vitro and in vivo Evaluation

Verma¹,

Kaushik²,

Almeer³

et al. 2021

IJN

Self Cite

View full text Add to dashboard Cite

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“…The tetragonal crystal structure of the BaTiO 3 shell and the cubic structure of the CoFe 2 O 4 core has been shown using X-ray diffraction (XRD) [ 30 ]. Microscopy images of MENs show an irregular-sphere-like morphology [ 98 , 99 ]. MENs offer advantages in that they are able/show potential to (i) achieve targeting driven by an external magnetic force, (ii) provide on-demand externally controlled drug release and (iii) provide image-guided precision drug delivery [ 30 ].…”

Section: Drug Permeation Challenges In Cns Tb Treatmentmentioning

confidence: 99%

“…Furthermore, focused ion beam transmission electron microscope (FIB-TEM) analysis of microglial cells demonstrated a non-agglomerated distribution of MENs inside the cell and no loss of their elemental crystalline characteristics [ 105 ]. Pandey et al [ 98 ] demonstrated that MENs displayed enhanced cell uptake (via microglial brain cells) and controlled drug release. The authors further confirmed that the AC-magnetic field stimulated at 60 Oe confirmed the localized surface potential enhancement of MENs.…”

Section: Drug Permeation Challenges In Cns Tb Treatmentmentioning

confidence: 99%

Permeation Challenges of Drugs for Treatment of Neurological Tuberculosis and HIV and the Application of Magneto-Electric Nanoparticle Drug Delivery Systems

et al. 2021

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The anatomical structure of the brain at the blood–brain barrier (BBB) creates a limitation for the movement of drugs into the central nervous system (CNS). Drug delivery facilitated by magneto-electric nanoparticles (MENs) is a relatively new non-invasive approach for the delivery of drugs into the CNS. These nanoparticles (NPs) can create localized transient changes in the permeability of the cells of the BBB by inducing electroporation. MENs can be applied to deliver antiretrovirals and antibiotics towards the treatment of human immunodeficiency virus (HIV) and tuberculosis (TB) infections in the CNS. This review focuses on the drug permeation challenges and reviews the application of MENs for drug delivery for these diseases. We conclude that MENs are promising systems for effective CNS drug delivery and treatment for these diseases, however, further pre-clinical and clinical studies are required to achieve translation of this approach to the clinic.

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“…Recent studies established engineered SPIONs using either a combination of hybrid concept or surface attachment of fluorescent probes in multistep synthesis processes. Kaushik et al extensively developed the various magneto-optical and magneto-electric nanosystems for magnetic field guided drug delivery and cancer therapy in biomedical applications. − Chen et al designed silica coated magnetic nanoparticles combined with fluorescent quantum dots (QDs) as multimodal imaging probe . Feld et al fabricated hybrid quantum dots/quantum rods with tunable magnetic and fluorescent properties for biomedical applications .…”

Section: Introductionmentioning

confidence: 99%

Fluorescent Mantle Carbon Coated Core–Shell SPIONs for Neuroengineering Applications

Tiwari

Kumar

Shefi

et al. 2020

ACS Appl. Bio Mater.

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Superparamagnetic iron oxide nanoparticles (SPIONs) have been used for a variety of biomedical applications, from multimodal imaging to the mechanical activity of cells and tissues. Herein, we present fluorescently mantled carbon coated core−shell superparamagnetic iron oxide nanoparticles (FC-SPIONs) as an excellent material to promote the neuronal differentiation and neuronal network outgrowth in neural tissue engineering applications. Morphological, structural, and functional group characterizations were systematically investigated. FC-SPIONs showed superior magnetic and inherent fluorescence characteristic properties. Furthermore, FC-SPIONs interactions against neuronal PC12 cells showed promising results and deliberate their potential for significant applications in neuroengineering. Interestingly, FC-SPIONs were assessed as biocompatible and promoted the neuronal PC12 cell differentiation process. Accompanied by these results, network outgrowth and branching patterns of neuronal processes can be regulated using FC-SPIONs. Importantly, FC-SPIONs are promising due to their biocompatibility and selective affinity toward neuronal cells, paving the way for neuronal differentiation and outgrowth and neuronal therapeutics in neuroengineering applications.

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Single-Entity Approach to Investigate Surface Charge Enhancement in Magnetoelectric Nanoparticles Induced by AC Magnetic Field Stimulation

Cited by 24 publications

References 45 publications

Improved Pharmacodynamic Potential of Rosuvastatin by Self-Nanoemulsifying Drug Delivery System: An in vitro and in vivo Evaluation

Improved Pharmacodynamic Potential of Rosuvastatin by Self-Nanoemulsifying Drug Delivery System: An in vitro and in vivo Evaluation

Permeation Challenges of Drugs for Treatment of Neurological Tuberculosis and HIV and the Application of Magneto-Electric Nanoparticle Drug Delivery Systems

Fluorescent Mantle Carbon Coated Core–Shell SPIONs for Neuroengineering Applications

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