Single Fraction Versus Fractionated Linac-Based Stereotactic Radiotherapy for Vestibular Schwannoma: A Single-Institution Experience

Radiotherapy for vestibular schwannoma: Review of recent literature results

“…Neither 5-year trigeminal nerve preservation, nor useful hearing preservation probability was significantly different between the patients treated by SRS and FSRT. 25 In a mono-institutional experience from University of Bangkok, a comparing analysis from 139 consecutive patients was performed. SRS (12 Gy) was given in 39 lesions ≤ 3 cm, hypo-fractionated FSRT (5 Gy × 4-5, 6 Gy × 3, and 3 Gy × 10) in 79 lesions and FSRT (50 Gy in 25 fractions) in 28 lesions.…”

Hearing preservation after LINAC radiosurgery and LINAC radiotherapy for vestibular schwannoma

“…In our LINAC SRT analysis, a total of 629 patients across 12 studies met our selection criteria (Supplementary Table 2) [24][25][26]28,32,[44][45][46][47][48][49][50] with an overall hearing preservation of 75.3% (Table 2). [24][25][26]28,32,[44][45][46][47][48][49][50] The average age of patients was 53.3 years (±6.8 years) with a mean follow-up period of 38.5 months (±29.7 months).…”

“…[24][25][26]28,32,[44][45][46][47][48][49][50] The average age of patients was 53.3 years (±6.8 years) with a mean follow-up period of 38.5 months (±29.7 months). The average radiation dose to the tumor margin was 36.8 Gy.…”

Vestibular Schwannoma: The Evolution of Hearing and Tumor Size in Natural Course and after Treatment by LINAC Stereotactic Radiosurgery

“…At the last available measurement (mean follow-up time: 39 months), 9% of the patients treated by LINAC SRS experienced tumor progression and 91% presented with stability or regression of tumor size. Other published LINAC SRS series reported local control of 89-97% with a mean follow-up ranging from 28 to 128 months [Anderson et al, 2014;Benghiat et al, 2014;Collen et al, 2011;Lo et al, 2014;Roos et al, 2012].…”

“…In our study, preservation of functional hearing reached 36% at the last observation measurement with a mean follow-up time of 39 months (6-84). The range of hearing preservation after LINAC SRS from single institution reports has been 24-65% [Anderson et al, 2014;Benghiat et al, 2014;Collen et al, 2011;Lo et al, 2014]. Roos et al [2012] demonstrated that hearing preservation after LINAC SRS progressively decreased to 24% at 10 years, despite the fact that hearing preservation at 5 years was 57%.…”