Single-molecule optical switching of terrylene in p-terphenyl

Kulzer, Florian; Kummer, S.; Matzke, R.; Bräuchle, Chr.; Basché, Th.

doi:10.1038/42674

Cited by 111 publications

(91 citation statements)

References 13 publications

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“…In comparison to single atoms, single molecules offer the advantage of much longer observation times. Experiments with one single molecule over more than 20 days have been reported [19]. Single molecules have previously been employed as a source for triggered single photons using rapid adiabatic passage [5] and pulsed optical pumping [4,6].…”

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confidence: 99%

Indistinguishable Photons from a Single Molecule

et al. 2005

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We report the results of coincidence counting experiments at the output of a Michelson interferometer using the zero-phonon-line emission of a single molecule at 1.4 K. Under continuous wave excitation, we observe the absence of coincidence counts as an indication of two-photon interference. This corresponds to the observation of Hong-Ou-Mandel correlations and proves the suitability of the zero-phonon-line emission of single molecules for applications in linear optics quantum computation.

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Indistinguishable Photons from a Single Molecule

et al. 2005

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“…The frequency of the ZPL can be shifted by mechanical strains or electric fields, including those caused by local degrees of freedom still active at the cryogenic temperature of the experiment. Such dynamics lead to spectral diffusion or to spectral jumps of the ZPL [20][21][22], and should therefore be eliminated or minimized for sensing applications. For example, the ZPL is very sensitive to librations of any methyl groups present in the host matrix [23].…”

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Single Molecule as a Local Acoustic Detector for Mechanical Oscillators

2014

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A single molecule can serve as a nanometer-sized detector of acoustic strain. Such a nanomicrophone has the great advantage that it can be placed very close to acoustic signal sources and high sensitivities can be achieved. We demonstrate this scheme by monitoring the fluorescence intensity of a single dibenzoterrylene molecule in an anthracene crystal attached to an oscillating tuning fork. The characterization of the vibration amplitude and of the detection sensitivity is a first step towards detection and control of nanomechanical oscillators through optical detection and feedback.

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“…Fluorescence switching was first reported for a variant of the fluorescent protein, YFP (yellow fluorescent protein), which was shown to cycle reversibly between a fluorescent and a dark state by alternating exposure to blue and violet light (Dickson et al 1997). Similar effects have been shown with synthetic organic fluorophores (Kulzer et al 1997;Irie et al 2002). One such example is the red cyanine dye Cy5, which can be reversibly converted between a fluorescent state and a nonfluorescent state (Bates et al 2005;Heilemann et al 2005).…”

Section: Photoswitchable Fluorescent Moleculesmentioning

confidence: 60%

Stochastic Optical Reconstruction Microscopy (STORM): A Method for Superresolution Fluorescence Imaging

Bates¹,

Jones²,

Zhuang³

2013

Cold Spring Harb Protoc

104

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The relatively low spatial resolution of the optical microscope presents significant limitations for the observation of biological ultrastructure. Subcellular structures and molecular complexes essential for biological function exist on length scales from nanometers to micrometers. When observed with light, however, structural features smaller than 0.2 µm are blurred and are difficult or impossible to resolve. In this article, we describe stochastic optical reconstruction microscopy (STORM), a method for superresolution imaging based on the high accuracy localization of individual fluorophores. It uses optically switchable fluorophores: molecules that can be switched between a nonfluorescent and a fluorescent state by exposure to light. The article discusses photoswitchable fluorescent molecules, STORM microscope design and the imaging procedure, data analysis, imaging of cultured cells, multicolor STORM, and three-dimensional (3D) STORM. This approach is generally applicable to biological imaging and requires relatively simple experimental apparatus; its spatial resolution is theoretically unlimited, and a resolution improvement of an order of magnitude over conventional optical microscopy has been experimentally demonstrated.

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Single-molecule optical switching of terrylene in p-terphenyl

Cited by 111 publications

References 13 publications

Indistinguishable Photons from a Single Molecule

Indistinguishable Photons from a Single Molecule

Single Molecule as a Local Acoustic Detector for Mechanical Oscillators

Stochastic Optical Reconstruction Microscopy (STORM): A Method for Superresolution Fluorescence Imaging

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