Sinonasal inflammatory myofibroblastic pseudotumor (plasma cell granuloma)

Wang

BMC Musculoskelet Disord

et al. 2020

Background Plasma cell granuloma (PCG) is a rare non-neoplastic entity, with the precise etiology remaining unclear. Vertebra-affected spinal PCG has not been reported yet. This report presented a case with cross-segment spinal PCG in thoracolumbar region. Case presentation A 32-year-old male patient presented to the authors’ hospital since his health check-up results showed osteolytic lesions in the thoracolumbar spine. He felt asymptomatic throughout the course. Radiological examination revealed destructive changes at T12 and L1 vertebrae. Whereas laboratory examination excluded malignant tumor. The results of routine incisional biopsy remained inconclusive, thereby necessitating complete excision of the lesions. Finally, the infiltration of plasma cells observed by pathological examination of the surgical specimen confirmed the diagnosis of PCG. Conclusions To the authors’ knowledge, this was the first case of cross-segment spinal PCG with osteolytic property. The possibility of PCG should be considered for the diagnosis and differential diagnosis of an osteolytic lesion in the spine. Since the etiology of PCG is unknown, the disorder was confirmed based on excluded diagnosis. Surgical resection is recommended both for the definite diagnosis and treatment of spinal PCG.

Section: Discussionmentioning

confidence: 99%

Cross-segment spinal plasma cell granuloma:a case report

Wang

BMC Musculoskelet Disord

et al. 2020

“…Only 19 associated literatures and 28 cases (10 males and 18 females, average age 41.04 years, range 10-75 years) were identified (Table 1). [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] The main clinical manifestations are nasal congestion (13/28), epistaxis (10/28), facial discomfort or facial swelling and pain (9/28), and ocular symptoms (7/ 28). The nasal cavity displayed tumor involvement in one side in 26 cases (10 left side, 16 right side) and both sides in the other 2 cases.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Few cases have been reported. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Here, we present a case of IP in the maxillary sinus, and its clinical features were summarized through literature review.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Pseudotumor in the Nasal Cavity and Sinuses: A Case Report and Associated Literature Review

Wang

et al. 2020

Ear Nose Throat J

Inflammatory pseudotumor (IP) is a clinically aggressive but histologically benign condition of unknown cause. It rarely appears in the nasal cavity and sinuses. Here, we describe a 24-year-old female with the main symptom of right nasal obstruction. Examinations showed dilation in the right maxillary sinus and a pale neoplasm in the nasal cavity. The neoplasm was completely excised under endoscope. Postoperative pathology showed significant proliferation of plasma cells and lymphocytes, indicating the presence of IP. No recurrence was found during 20 months of follow-up. Only 28 cases (10 males and 18 females, average 41.04 years) have been reported on Pubmed. The main clinical manifestations were nasal obstruction, epistaxis, facial swelling and pain, eyeball protrusion, diplopia, and other ocular symptoms. Inflammatory pseudotumor always erodes the surrounding bone and requires active treatments. Surgery is the optimal option with a good prognosis.

Case Reports in Otolaryngology

“…The lesion has been given multiple labels depending on the predominant cells seen in the histopathology of the tumor; this includes inflammatory pseudotumor, plasma cell granuloma, and lately, inflammatory myofibroblastic tumor [2]. This rare pseudotumor can often be misdiagnosed in the early stages of diagnosis, and it can resemble malignant tumors both clinically and radiologically [3]. We report a case of a 38-year-old female who presented with a right nasolabial fold mass, which was later confirmed to be an IMT.…”

Section: Introductionmentioning

confidence: 99%

A Rare Presentation of Inflammatory Myofibroblastic Tumor in the Nasolabial Fold

Alshammari

Alzamami

Ashoor

et al. 2019

Inflammatory myofibroblastic tumor (IMT) is a benign lesion that occurs most frequently in the soft tissues and viscera. In the head and neck region, the tumor has been reported to occur in the orbit, tongue, nasopharynx, larynx, and paranasal sinuses and the central nervous system. Despite being a benign lesion, it exhibits infiltrative and destructive behaviours, making histopathological examination necessary to confirm the diagnosis. We report the case of a 38-year-old female presented with a right nasolabial fold mass, which was confirmed histologically to be an IMT. Surgical excision of the mass was achieved through a sublabial approach with an uneventful postoperative period. To the best of our knowledge, this is the first reported case of an IMT in the nasolabial fold.