Sinonasal outcomes in obstructive sleep apnea syndrome

Kuan, Edward C.; Tajudeen, Bobby A.; Peng, Kevin A.; Wang, Marilene B.

doi:10.1002/lary.25411

Cited by 16 publications

(24 citation statements)

References 20 publications

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“…Although the differences did not reach the chosen level of significance it indicates a clear association between nasal complaints and severity of disease. This verifies the results in the study by Kuan et al where sinonasal complaints evaluated by the SNOT-22 score seemed to be correlated to OSA severity [1]. …”

Section: Discussionsupporting

confidence: 91%

“…Sinonasal complaints are associated with obstructive sleep apnea (OSA) [1], and the relief of sinonasal obstruction has been shown to reduce subjective complaints of daytime sleepiness [2]. Excessive daytime sleepiness is one of the main symptoms in obstructive sleep apnea syndrome and a major concern due to the strong association with a reduction in motor skills such as handling vehicles and machines [3].…”

Section: Introductionmentioning

confidence: 99%

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Sinonasal Characteristics in Patients with Obstructive Sleep Apnea Compared to Healthy Controls

Moxness

Bugten

Thorstensen

et al. 2017

International Journal of Otolaryngology

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Background. The difference in nasal obstruction between OSA patients and healthy individuals is not adequately documented. Our aim was to describe the sinonasal quality of life and nasal function in OSA patients and healthy controls using the sinonasal outcome test-20 (SNOT-20), nasal obstruction visual analog scale (NO-VAS), and peak nasal inspiratory flow (PNIF). Methodology and Principal. Ninety-three OSA patients and 92 controls were included in a case-control study from 2010 to 2015. Results. Mean SNOT-20 score in the OSA group was 1.69 (SD 0.84) compared to 0.55 (SD 0.69) in controls (p < 0.001, 95% CI [0.9, 1.4]). The mean NO-VAS score was 41.3 (SD 12.8) and 14.7 (SD 14.4) in the OSA group and controls, respectively, (p < 0.001, 95% CI [22.7, 30.6]). PNIF measured 105 litres/minute in the OSA group and 117 litres/minute in controls (p < 0.01, 95% CI [−21.8, −3.71]). There was a positive correlation between subjective nasal obstruction and change in PNIF after decongestion in the control group alone. Conclusions. OSA patients have a reduced sinonasal QoL and lower peak nasal inspiratory flow compared to controls. Treatment of nasal obstruction in OSA patients should be made a priority along with treatment of the ailment itself.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Sinonasal Characteristics in Patients with Obstructive Sleep Apnea Compared to Healthy Controls

Moxness

Bugten

Thorstensen

et al. 2017

International Journal of Otolaryngology

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“…Repetitive obstructive episodes cause ischemia‐reperfusion injury to the airway, all the while OSA patients have increased systemic inflammatory mediators predisposing the soft tissues to free‐radical development . These same theories have been proposed recently for two small cohort samples finding higher levels of sinonasal complaints in OSA patients, though no study has definitively linked OSA and higher rates of sinusitis. It is worth mentioning that a separate study of our cohort found no difference in sinusitis QOL scores (by Sino‐Nasal Outcome Test) between OSA and non‐OSA patients.…”

Section: Discussionmentioning

confidence: 88%

Are chronic cough and laryngopharyngeal reflux more common in obstructive sleep apnea patients?

et al. 2018

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Objectives/Hypothesis To assess if there is a significant difference in the prevalence and severity of chronic cough symptoms in obstructive sleep apnea (OSA) patients versus non‐OSA patients and examine this relationship in regard to laryngopharyngeal reflux (LPR) symptoms. Study Design Prospective cohort study. Methods Patients referred to Northwestern Medicine Sleep Lab for home sleep testing were enrolled. Patients filled out the Leicester Cough Questionnaire (LCQ) and Reflux Symptom Index (RSI) before completing sleep testing. Home sleep testing results were reviewed, and patients were separated into non‐OSA and OSA groups by standard Apnea‐Hypopnea Index (AHI) criteria. Demographic characteristics and questionnaire scores of the two groups were compared. The relationship between OSA severity, as determined by AHI, and LCQ and RSI scores was assessed. Results Of the 52 patients enrolled, 33 patients met criteria for OSA and 19 patients did not. Comparing patients without OSA versus those with OSA, there was a significant difference in mean LCQ score (129.9 vs. 120.0, respectively; P = .02), implying worse cough symptoms among OSA patients, and mean RSI score (3.2 vs. 11.2, respectively; P = .0013), implying worse upper‐airway reflux symptoms among OSA patients. There was a significant correlation between LCQ score and AHI (r = –0.39, P = .0061) and between RSI score and AHI (r = 0.37, P = .0078). Conclusions OSA patients demonstrate worse chronic cough and LPR‐related quality of life versus non‐OSA patients. Furthermore, the severity of these quality‐of‐life measures was correlated with the severity of the AHI. Chronic cough and particularly the pharyngeal LPR symptoms may be associated with the presence and severity of OSA. Level of Evidence 2 . Laryngoscope, 129:1244–1249, 2019

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“…4 The SNOT-22 questionnaire interrogates patients on rhinologic, nonrhinologic-otolaryngic, psychological, and sleep functions. 4,5 We used these 4 "subdomains" for our analyses, following the individual item categorization described by Hopkins et al 4 and Kuan et al 6 : rhinologic (need to blow nose, sneezing, runny nose, nasal obstruction, loss of smell/taste, postnasal drip, thick nasal discharge), nonrhinologic-otolaryngic (cough, ear fullness, dizziness, ear pain, facial pain/pressure), sleep function (difficulty falling asleep, waking up at night, lack of good night's sleep, waking up feeling tired), and psychological (fatigue, reduced productivity, reduced concentration, frustration/restlessness/irritability, sadness, embarrassment). The magnitude of CRS burden on sinus CT scan was calculated using the Lund-Mackay staging system; total scores range from zero (no disease) to a maximum of 24 points.…”

Section: Methodsmentioning

confidence: 99%

“…We used these 4 “subdomains” for our analyses, following the individual item categorization described by Hopkins et al . and Kuan et al …”

Section: Methodsmentioning

confidence: 99%

Gender‐specific analysis of outcomes from endoscopic sinus surgery for chronic rhinosinusitis

Lal

Golisch

Elwell

et al. 2016

Int Forum Allergy Rhinol

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Sinonasal outcomes in obstructive sleep apnea syndrome

Abstract: NA.

Cited by 16 publications

References 20 publications

Sinonasal Characteristics in Patients with Obstructive Sleep Apnea Compared to Healthy Controls

Sinonasal Characteristics in Patients with Obstructive Sleep Apnea Compared to Healthy Controls

Are chronic cough and laryngopharyngeal reflux more common in obstructive sleep apnea patients?

Gender‐specific analysis of outcomes from endoscopic sinus surgery for chronic rhinosinusitis

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