Siolmatra brasiliensis (Cogn.) Baill., Cucurbitaceae, acute toxicity in mice

Lima, Aliny Pereira de; Barbosa, C. E.; Pereira, Flávia C.; Vilanova-Costa, Cesar Augusto Sam Tiago; Ribeiro, Alessandra S. B. B.; Silva, Hugo D.; Azevedo, Neucírio Ricardo de; Gomes‐Klein, Vera Lúcia; Silveira-Lacerda, Elisângela de Paula

doi:10.1590/s0102-695x2010005000046

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…Siolmatra brasiliensis (Cogn.) Baill is a climbing plant belonging to the Cucurbitaceae family that occurs in the central region of Brazil, especially in Cerrado and Pantanal where it is popularly known as "taiuiá" or "cipó-tauá" [1]. Its roots are considered a purifying and antisyphilis agent [2].…”

Section: Introductionmentioning

confidence: 99%

“…Infusions prepared with roots are widely used in traditional medicine as an analgesic for treatment of toothache [2] and for the treatment of ulcers [3]. Due to the presence of cucurbitacins, compounds responsible for the bitter tang and high toxicity, Lima et al [1] showed some toxicological effects of S. brasiliensis only at very high doses (i.e., 2 g/kg). In a recent study, Dos Santos et al [3] performed a regional ethnopharmacological use of the infusion of S. brasiliensis stems in Mato Grosso (Brazil) and demonstrated that the crude hydroethanol extract reduced the hyperglycemia and glycosuria in diabetic mice.…”

Section: Introductionmentioning

confidence: 99%

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Study on the Antinociceptive Activity and Mechanism of Action of Isolated Saponins from Siolmatra brasiliensis (Cogn.) Baill

et al. 2019

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Infusions of roots of Siolmatra brasiliensis (Cogn.) Baill, (“taiuiá”, “cipó-tauá”) are used for toothache pain and ulcers. We aimed to study the antinociceptive effects and identify the possible mechanism of action of this plant and its isolated substances (cayaponoside A1, cayaponoside B4, cayaponoside D, and siolmatroside I). Hydroethanol extract (HE), ethyl acetate fraction (EtOAc), and isolated saponins were evaluated in chemical and thermal models of pain in mice. Animals were orally pretreated and evaluated in the capsaicin- or glutamate-induced licking and in the hot plate tests. The antinociceptive mechanism of action was evaluated using the hot plate test with the following pretreatments: Atropine (cholinergic antagonist), naloxone (opioid antagonist), or L-NAME (nitric oxide synthase inhibitor). All extracts and isolated saponins increased the area under the curve in the hot plate test. Tested substances induced a higher effect than the morphine-treated group. Our data suggest that stems of S. brasiliensis and their isolated substances present antinociceptive effects. Cholinergic and opioidergic pathways seem to be involved in their mechanism of action. Taken together our data corroborate the traditional use of the plant and expands the information regarding its use.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Study on the Antinociceptive Activity and Mechanism of Action of Isolated Saponins from Siolmatra brasiliensis (Cogn.) Baill

et al. 2019

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“…Cytotoxic studies showed that the ethanolic extract of the stems is toxic in low doses for S180 tumor cells (5 mg/ mL) and macrophages (2.5 and 5 mg/mL) (Lima et al 2006). In low doses (10-100 mg/kg), the ethanolic extract of the stems of S. brasiliensis does not show toxicity in mice, but at higher doses (1000-2000 mg/kg) some adverse effects, even mortality, have been observed (Lima et al 2010). There are no studies about the chemical profile of this species and the research about the biological and pharmacological potential is limited.…”

Section: Introductionmentioning

confidence: 99%

A new dammarane saponin and other triterpenoids from Siolmatra brasiliensis and evaluation of the antidiabetic activity of its extract

Santos

Borges

Silva

et al. 2016

Pharmaceutical Biology

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Context Siolmatra brasiliensis (Cogn.) Baill (Cucurbitaceae) is a climbing plant widely used for the treatment of diabetes mellitus symptoms. Objective This work evaluates the antidiabetic activity of an extract of S. brasiliensis in streptozotocin-diabetic rats and promotes the phytochemical investigation to isolate the major compounds of the same extract. Materials and methods Male Wistar rats were divided into normal (N) and diabetic rats (DC) treated with water; diabetic rats treated with 3U insulin (DI) or with 250 (DSb250) or 500 mg/kg (DSb500) of hydroalcoholic extract of the stalks of S. brasiliensis, via oral gavage, for 21 days. Physiological and biochemical parameters classically altered in diabetes were monitored. The triterpenoids were isolated from the ethyl acetate fraction under silica gel column chromatography and Sephadex-LH20 methods and their structures were determined by NMR, HR-ESI-MS and DC analysis. Results When compared with DC, DSb250 rats showed a reduction in the hyperglycemia (DC: 26.46 ± 0.69 versus DSb250: 19.67 ± 1.06 mmol/L) and glycosuria (DC: 43.02 ± 3.19 versus DSb250: 28.46 ± 2.14 mmol/24 h) and increase in hepatic glycogen (DC: 14.44 ± 1.26 versus DSb250: 22.08 ± 4.26 mg/g). Three known cucurbitacins were isolated from a hydroalcoholic extract of S. brasiliensis, i.e., cayaponosides A1, B4, D, and a new dammarane saponin 3-O-β-d-gentiobiosyl-26-O-β-d-glucopyranosyl-20-hydroxydammar-24-ene. The structures of these compounds were elucidated by spectral data analysis of the natural products and their acetyl derivatives. Discussion and conclusion The known cucurbitacins and/or the new identified saponin may be related with the antidiabetic activity of S. brasiliensis.

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Phytochemicals against anti‐diabetic complications: targeting the advanced glycation end product signaling pathway

et al. 2021

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Siolmatra brasiliensis (Cogn.) Baill., Cucurbitaceae, acute toxicity in mice

Cited by 5 publications

References 20 publications

Study on the Antinociceptive Activity and Mechanism of Action of Isolated Saponins from Siolmatra brasiliensis (Cogn.) Baill

Study on the Antinociceptive Activity and Mechanism of Action of Isolated Saponins from Siolmatra brasiliensis (Cogn.) Baill

A new dammarane saponin and other triterpenoids from Siolmatra brasiliensis and evaluation of the antidiabetic activity of its extract

Phytochemicals against anti‐diabetic complications: targeting the advanced glycation end product signaling pathway

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