Site‐Specific Assembly of DNA‐Based Photonic Wires by Using Programmable Polyamides

Wu, Songhua; Schuster, Markus; Bagshaw, Clive R.; Rant, Ulrich; Burley, Glenn A.

doi:10.1002/anie.201006735

Cited by 49 publications

(27 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another highly efficient DNA-based photonic wire was fabricated by Su et al 17 by using three different dyes doped into DNA and pyrrole-imidazole polyamides. They observed that energy transfer over 80 base pairs of the DNA chain (B27 nm) could be achieved using this approach.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Optical, electro-optic and optoelectronic properties of natural and chemically modified DNAs

Kwon

Choi

Jin

2012

Polym J

View full text Add to dashboard Cite

This article reviews recent findings on the optical, electro-optic and optoelectronic properties of natural and modified DNAs. When the sodium (Na þ ) ions of DNA are replaced with long alkyl quaternary ammonium (Q þ ) ions, the resulting compositions (Q þ DNA À ) are organic-soluble, and thin films produced using these materials reveal many interesting optical and optoelectronic properties. These films tend to form well-structured supramolecular assemblies. In contrast, natural DNAs are water-soluble and hygroscopic. DNAs are strong absorbers of UV wavelengths in the region of 260 nm. The Q þ DNA À films are excellent dielectrics that can be utilized as insulating layers in organic thin film transistors. Chemical modification of the Q þ parts results in many interesting structures that can be used in a wide variety of optical and optoelectronic devices. This review specifically deals with the optical and fluorescence properties of, organic lasing composites, the nonlinear optical characteristics of, light-emitting diodes, and photovoltaic cells based on natural and modified DNAs.

show abstract

Section: Discussionmentioning

confidence: 99%

“…We previously published a review article 16 on the broader spectrum of the materials science of DNA. Recently, Su et al 17 discussed DNA-programmed photonic arrays and devices. They also suggested future opportunities in the area of DNA photonics.…”

Section: Introductionmentioning

confidence: 99%

Optical, electro-optic and optoelectronic properties of natural and chemically modified DNAs

Kwon

Choi

Jin

2012

Polym J

View full text Add to dashboard Cite

show abstract

“…Other approaches were undertaken to direct energy transfer, as for instance the use of an oxazole yellow attached to a sequence‐specific polyamide minor‐groove binder dye, which binds a dsDNA terminated by two different dyes (a pacific blue dye and a cyanine dye) . The oxazole yellow dye located at the center of the DNA via the polyamide groove binding permitted the energy transfer in between the two dyes at the DNA extremities, distant from 21 base pairs.…”

Section: Towards Functional Self‐assembliesmentioning

confidence: 99%

From Interaction to Function in DNA‐Templated Supramolecular Self‐Assemblies

Surin

Ulrich

2020

ChemistryOpen

View full text Add to dashboard Cite

DNA-templated self-assembly represents a rich and growing subset of supramolecular chemistry where functional selfassemblies are programmed in a versatile manner using nucleic acids as readily-available and readily-tunable templates. In this review, we summarize the different DNA recognition modes and the basic supramolecular interactions at play in this context. We discuss the recent results that report the DNA-templated self-assembly of small molecules into complex yet precise nanoarrays, going from 1D to 3D architectures. Finally, we show their emerging functions as photonic/electronic nanowires, sensors, gene delivery vectors, and supramolecular catalysts, and their growing applications in a wide range of area from materials to biological sciences.[a] Dr.

show abstract

“…Another application of fluorescent conjugates of Py-Im polyamides is the studies of DNA-based photonic wires. [54][55][56][57] W. Su et al prepared 21-, 55-or 80-bp DNA fragments containing two fluorophores, Pacific Blue at one end and Cy3 at the other, as well as an oxazole yellow-conjugated Py-Im polyamide that binds to the internal regions of these DNAs. By measuring emission spectra of a mixture of the DNA and the Py-Im polyamide, they demonstrated that the oxazole yellow conjugate mediated the energy transfer from the Pacific Blue moiety to Cy3.…”

Section: Synthesis Of the Conjugates Of Py-im Polyamides With Cy3 Or Cy5mentioning

confidence: 99%

Construction and characterization of Cy3- or Cy5-conjugated hairpin pyrrole–imidazole polyamides binding to DNA in the nucleosome

et al. 2014

View full text Add to dashboard Cite

Sequence-specific DNA-binding modules, N-methylpyrrole (Py)-N-methylimidazole-(Im) polyamides have been recently conjugated with fluorophores, and some of these conjugates could be used for detection of specific DNA sequences. In this study, we synthesized two Py-Im polyamides 1 and 2, which interact with the 145-bp nucleosome positioning sequence 601. We conjugated the cyanine dyes Cy3 or Cy5 with 1 or 2. In the absence of target DNA, the fluorescent conjugate of a Py-Im polyamide had lower fluorescence intensity compared with Cy3 or Cy5 alone. In the presence of either the target DNA or nucleosome, the fluorescence intensity of the conjugates increased. Furthermore, we observed a Förster resonance energy transfer between the Cy3-Py-Im polyamide and Cy5-Py-Im polyamide on the nucleosome. These results open up the possibilities that fluorescent conjugates of Py-Im polyamides can be used for characterization of the dynamic interactions within protein-DNA complexes.

show abstract

Site‐Specific Assembly of DNA‐Based Photonic Wires by Using Programmable Polyamides

Cited by 49 publications

References 29 publications

Optical, electro-optic and optoelectronic properties of natural and chemically modified DNAs

Optical, electro-optic and optoelectronic properties of natural and chemically modified DNAs

From Interaction to Function in DNA‐Templated Supramolecular Self‐Assemblies

Construction and characterization of Cy3- or Cy5-conjugated hairpin pyrrole–imidazole polyamides binding to DNA in the nucleosome

Contact Info

Product

Resources

About