Size-controlled synthesis of hydroxyapatite nanorods in the presence of organic modifiers

Wang, Aili; Yin, Hengbo; Liu, Dong; Wu, Huixiong; Ren, Min; Jiang, Tingshun; Cheng, Xiaonong; Xu, Yang

doi:10.1016/j.matlet.2006.08.019

Cited by 58 publications

(39 citation statements)

References 25 publications

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“…Kang). methods, such as sol-gel, hydrothermal, microemulsion, and precipitation, were applied to the preparation of nano-sized HAp powders [3][4][5][6][7][8][9][10]. Liquid-solution methods have advantages in controlling the morphology and mean size of the HAp powders.…”

Section: Introductionmentioning

confidence: 99%

Nano-sized hydroxyapatite powders prepared by flame spray pyrolysis

Cho

Kang

2008

Journal of Alloys and Compounds

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Section: Introductionmentioning

confidence: 99%

Nano-sized hydroxyapatite powders prepared by flame spray pyrolysis

Cho

Kang

2008

Journal of Alloys and Compounds

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“…Such differences are in line with frequent reports showing that Hap synthesis at high temperature (T . 1008C) leads to crystalline and well-defined prismatic particles, while lower temperature synthesis generally favours thinner particles with less perceptible contours and lower crystallinity [6,[30][31][32]. Significant changes in the morphology were detected in WCS nanoparticles after sterilization.…”

mentioning

confidence: 99%

Relevance of the sterilization-induced effects on the properties of different hydroxyapatite nanoparticles and assessment of the osteoblastic cell response

Santos

Gomes

Duarte

et al. 2012

J. R. Soc. Interface.

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Hydroxyapatite (Hap) is a calcium phosphate with a chemical formula that closely resembles that of the mineral constituents found in hard tissues, thereby explaining its natural biocompatibility and wide biomedical use. Nanostructured Hap materials appear to present a good performance in bone tissue applications because of their ability to mimic the dimensions of bone components. However, bone cell response to individual nanoparticles and/or nanoparticle aggregates lost from these materials is largely unknown and shows great variability. This work addresses the preparation and characterization of two different Hap nanoparticles and their interaction with osteoblastic cells. Hap particles were produced by a wet chemical synthesis (WCS) at 378C and by hydrothermal synthesis (HS) at 1808C. As the ultimate in vivo applications require a sterilization step, the synthesized particles were characterized 'as prepared' and after sterilization (autoclaving, 1208C, 20 min). WCS and HS particles differ in their morphological (size and shape) and physicochemical properties. The sterilization modified markedly the shape, size and aggregation state of WCS nanoparticles. Both particles were readily internalized by osteoblastic cells by endocytosis, and showed a low intracellular dissolution rate. Concentrations of WCS and HS particles less than 500 mg ml 21 did not affect cell proliferation, F-actin cytoskeleton organization and apoptosis rate and increased the gene expression of alkaline phosphatase and BMP-2. The two particles presented some differences in the elicited cell response. In conclusion, WCS and HS particles might exhibit an interesting profile for bone tissue applications. Results suggest the relevance of a proper particle characterization, and the interest of an individual nanoparticle targeted research.

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“…After modifying HAP with Tween 20, there appeared to be small-sized HAP particles. This was caused by steric hindrance from the dendriform structure of Tween 20 as well as strongly coordinated Tween 20 on the HAP surface [46]. PEG 600 had the opposite effect when it was used to modify HAP.…”

Section: Modifier Size and Structurementioning

confidence: 99%

“…The increased length may be due to the flexibility of the PEG 600, a linear molecule with many ether bonds. As the temperature increases, the flexibility of the PEG molecules in an aqueous solution also increases and hence the PEG molecules should cause a lengthening axis orientation of HAP [46].…”

Section: Modifier Size and Structurementioning

confidence: 99%

Design and Synthesis of Hydroxyapatite with Organic Modifiers for Application to Environmental Remediation

Daniels

Alexandratos

2010

Waste Biomass Valor

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Composites of hydroxyapatite (HAP) and organic compounds have been prepared for biomedical applications. These same composites may be applicable to environmental remediation. The organic compounds used for modification include organic acids, calcium chelating agents, proteins, compounds capable of ring-opening polymerization, and hydrophobic silicon-containing molecules. The methods for modification that have been studied are co-precipitation and post-HAP particle formation. It is proposed that modified-HAP (mHAP) could have enhanced metal ion selectivities. The techniques used to synthesize mHAP are reviewed.

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Size-controlled synthesis of hydroxyapatite nanorods in the presence of organic modifiers

Cited by 58 publications

References 25 publications

Nano-sized hydroxyapatite powders prepared by flame spray pyrolysis

Nano-sized hydroxyapatite powders prepared by flame spray pyrolysis

Relevance of the sterilization-induced effects on the properties of different hydroxyapatite nanoparticles and assessment of the osteoblastic cell response

Design and Synthesis of Hydroxyapatite with Organic Modifiers for Application to Environmental Remediation

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