Size-selective recognition of catecholamines by molecular imprinting on silica–alumina gel

Ling, Tzong-Rong; Syu, Yau Zen; Tasi, Yau-Ching; Chou, Tse‐Chuan; Liu, Chung-Chiun

doi:10.1016/j.bios.2005.02.009

Cited by 65 publications

(24 citation statements)

References 19 publications

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“…They are very useful materials for isolation and preconcentration of low concentration analytes employing the solid phase extraction (SPE) technique [14][15][16]. Although many papers have been published concerning utilization of MIPs in pharmaceutical science [17][18][19], only a few were devoted to dopamine isolation [20][21][22][23][24]. Recently, two scientific groups have published their results of the evaluation of dopamine imprinted polymers prepared using synthetic methods based on covalent [22] and non-covalent [23] approaches.…”

mentioning

confidence: 99%

Dopamine-Imprinted Polymers: Template-Monomer Interactions, Analysis of Template Removal and Application to Solid Phase Extraction

Luliński

Maciejewska

Bamburowicz-Klimkowska

et al. 2007

Molecules

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A dopamine-imprinted polymer (MIP) was prepared in aqueous methanol solution at 60 o C by free-radical cross-linking polymerization of methacrylic acid in the presence of ethylene glycol dimethacrylate as the cross-linker and dopamine hydrochloride as the template molecule. Its ability to isolate dopamine was evaluated as the basis of a solid phase extraction procedure and compared with that of a non-imprinted polymer (NIP). The binding of dopamine was 84.1% and 29.1% for MIP and NIP, respectively. Various reported post-polymerization treatments to reduce template bleeding were examined. In our case the lowest bleeding was achieved after applying a combined procedure: continuous extraction in a Soxhlet apparatus (CE), followed by microwaveassisted extraction (ME) to a level of 0.061 μg/mL. A simplified model of the templatemonomer complexes allowed rationalization of monomer choice based on the heats of complex formation at a PM3 level of theory.

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mentioning

confidence: 99%

Dopamine-Imprinted Polymers: Template-Monomer Interactions, Analysis of Template Removal and Application to Solid Phase Extraction

Luliński

Maciejewska

Bamburowicz-Klimkowska

et al. 2007

Molecules

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“…Several MIPs have been prepared with dopamine as the template molecule with some degree of success [25,26]. Direct imprinting of very polar adrenaline is still limited and the clear imprinting effect showing the difference between the MIP and nonimprinted polymers (NIPs) have not been demonstrated so far [27].…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted polymer for solid‐phase extraction of ephedrine and analogs from human plasma

Lasáková

Thiébaut

Jandera

et al. 2009

J of Separation Science

163

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A molecularly imprinted polymer (MIP) was synthesized and evaluated to selectively extract ephedrine from human plasma. The MIP synthesis was performed in chloroform with methacrylic acid as a functional monomer and the target alkaloid as a template molecule. The resulting MIP was applied to the selective extraction of ephedrine from a pure aqueous medium. A recovery about 74% was obtained using the MIP with only 7% on the nonimprinted polymer (NIP). A very straightforward selective SPE procedure was then successfully applied to the direct extraction of ephedrine from spiked human plasma with a high extraction recovery (68%) on the MIP with no recovery on the NIP. Moreover, the MIP was used for the selective extraction of catecholamine neurotransmitters, i.e. adrenaline and noradrenaline.

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“…The technique has been developed and widely used in many aspects in the last 20 years [4][5][6][7]. At present, the main methods for the preparation of molecularly imprinted materials include the pre-organized approach and the self-assembly approach, but the recognition and binding processes are usually accomplished in organic solvents.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Imprinted Porous Materials with High Selectivity for Luteolin

Xiang

Zhang

et al. 2009

Chem Eng & Technol

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In order to selectively separate luteolin from its crude solution, we synthesized imprinted porous materials with high recognition specificity for luteolin, using an imprinting technique. Modified luteolin was used as template, vinyltriethoxysilane as the functional monomer, and tetraethyl orthosilicate (TEOS) as the cross-linking agent. The results showed the following optimum reaction conditions: The reaction ratio between luteolin and acryloyl chloride was 1 : 2 (0.10 g/0.20 g), adding 1.0 g precursor; the feasible elution time was 12 h; when the molar quantity of modified template molecule was 0.01 mol and ethenyltriethyloxy-silane (VTEO) was 0.04 mol, the maximum yield reached 91.6 %. All samples were tested by Brunauer-Emmett-Teller method, Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy, equilibrium adsorption experiments and selective adsorption experiments. It was found that the imprinted porous materials showed excellent selectivity for luteolin in aqueous solution. Characterization by FTIR suggested that an addition reaction had occurred between the modified template molecule and VTEO while forming ester bonds in the functional precursor. Results from pore structure analysis indicated that the imprinted porous materials had good channels, and the average pore size of the prepared porous materials was between 35.85 and 95.82 Å. Adsorption dynamics analysis suggested that, when the adsorption time reached 3 h, the adsorption process had reached balance and the adsorption capacity was at steady state. These porous materials had highly selective recognition properties and high equilibrium adsorption capacity for the template molecule. The equilibrium adsorption capacity of the imprinted porous materials to the template molecule was 11.4 times that of the blank porous materials.

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Size-selective recognition of catecholamines by molecular imprinting on silica–alumina gel

Cited by 65 publications

References 19 publications

Dopamine-Imprinted Polymers: Template-Monomer Interactions, Analysis of Template Removal and Application to Solid Phase Extraction

Dopamine-Imprinted Polymers: Template-Monomer Interactions, Analysis of Template Removal and Application to Solid Phase Extraction

Molecularly imprinted polymer for solid‐phase extraction of ephedrine and analogs from human plasma

Preparation and Characterization of Imprinted Porous Materials with High Selectivity for Luteolin

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