Academic Stress has a negative influence on the learning process and student achievement. Among the efforts to reduce academic stress is by developing selfregulated learning, which is a behavior in which a person is able to manage his or her own learning process. On the other hand, in Islamic teachings an attitude called tawakal (trust in God's plan) is recommended for Muslims, which means to try and surrender to Allah. This attitude can be applied in various activities including learning, which are described with sincerity in learning and surrender to Allah after trying. The author in this study wanted to find out whether self-regulated learning and trust in learning had a significant effect on academic stress. By using quantitative methods, this study involved 150 active Muslim students at S1 level and equivalent to S1 (D4 and S1 extensions) in both public and private universities in Jakarta, Bogor, Depok, Tangerang and Bekasi. This study shows that self-regulated learning has a significant influence on academic stress. Tawakal in learning also has a significant effect on academic stress. Then selfregulated learning and tawakal in learning simultaneously proved to have results in academic stress on students.