Skin absorption in vitro of glycol ethers

Abstract

Our results confirm the high percutaneous absorption of the GEs tested. The Franz method might be helpful for obtaining a grading of skin notation for hydrophilic substances: in the case of glycol ethers, it can give us precise information about permeation risk, particularly important in the evaluation of exposure. In the case of solvents with high dermal absorption, the air concentration is no longer a sufficient measure of the total exposure to workers, and therefore merely respecting threshold limit values (TLVs) in the air is not necessarily enough to protect them.

Quantification of N-phenyl-2-naphthylamine by gas chromatography and isotope-dilution mass spectrometry and its percutaneous absorption ex vivo under workplace conditions

“…The use of Franz diffusion cells is a well-established ex vivo model to study drug delivery in pharmacology and extensive information is available on pharmaceuticals (for review: Bartosova and Bajgar 2012 ; Godin and Touitou 2007 ). Similarly, Franz cells have been used in toxicology to study the transdermal absorption of organophosphates (Thors et al 2016 ), glycol ethers (Larese Filon et al 1999 ), polybrominated flame retardants (Frederiksen et al 2016 ), and primary aromatic (di)amines such as aniline, o -toluidine, or 4,4′-methylenedianline (Lüersen et al 2006 ; Kenyon et al 2004 ). Less toxicological data are available on lipophilic compounds such as benzene (Adami et al 2006 ) and polycyclic aromatic hydrocarbons (Bartsch et al 2016 ), possibly due to their lower solubility in water and less pronounced skin penetration characteristics when compared to hydrophilic compounds.…”

In vitro evaluation of the efficacy of skin barrier creams and protective gloves on percutaneous absorption of industrial solvents

“…Enhancement of penetration for a single compound (e.g. glycol ethers) in a solvent mixture was also observed in other studies with diffusion cells (Larese Filon et al 1999).…”

Evaluation of Workers Exposed to Ethylene Glycol Monomethyl Ether and Ethylene Glycol Monomethyl Ether Acetate

“…However, in many cases, cotton masks were worn because of the inconvenience of wearing gas masks and the workers' poor understanding of their importance. EGME and EGMEA characteristically show high dermal absorption 19) , yet only 32% of the workers wore appropriate protective gloves. Many (43%) of the workers wore cotton gloves, but dermal absorption is still possible through the cotton gloves, especially when the gloves are wet due to direct contact with the solvents and due to perspiration resulting from the high temperatures during the time of the study.…”