Skin changes and dermatological life quality index in chronic kidney disease patients in a tertiary hospital in Southern Nigeria

Adejumo, Oluseyi Ademola; Madubuko, Roli; Olokor, Afeaje Benedicta; Aina, Omodele T

doi:10.4103/njcp.njcp_270_18

Cited by 9 publications

(6 citation statements)

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“…Embora sua fisiopatologia seja desconhecida, sugere-se que ocorra devido às alterações metabólicas e anemia, provavelmente relacionada com a DRC e não com a hemodiálise (Saray et al, 2004). Contudo, os dados foram contrastantes ao demonstrado por Falodun et al (2011), no qual as unhas meio-a-meio ou unhas de Lindsay foram as mais prevalentes com 40%, assim como por Adejumo et al (2019), com 45,7%, e Picó et al (1992) com 39%. Neste estudo, as unhas meio-a-meio foram evidenciadas em apenas 5,5%.…”

Section: Discussionunclassified

Avaliação das manifestações dermatológicas em pacientes com doença renal crônica em um serviço de hemodiálise no Distrito Federal

Cavalcanti,

Thomé,

Name

2024

RSD

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A doença renal crônica (DRC) é definida por perda progressiva e irreversível no número e na função dos néfrons por mais de 3 meses. Sabe-se que 82% dos pacientes com DRC em hemodiálise manifestam pelo menos uma alteração cutâneo-mucosa, podendo gerar um impacto negativo na sua qualidade de vida. O objetivo deste estudo foi conhecer o perfil clínico e epidemiológico da população renal crônica em um serviço de hemodiálise no Distrito Federal e avaliar a prevalência das principais manifestações dermatológicas desses pacientes. Trata-se de um estudo descritivo, retrospectivo, do tipo série de casos, com base na análise de prontuários, entrevistas e exames físicos no período de agosto de 2019 a janeiro de 2020. Foram incluídos 46 pacientes, sendo 52% do sexo feminino, com faixa etária predominante entre 40 e 50 anos. Todos os pacientes analisados apresentaram alguma manifestação dermatológica, com foco nas alterações ungueais (89,6%), xerose (83,3%) e alterações nas mucosas (77,1%). O estudo do perfil clínico e epidemiológico e das alterações cutâneo-mucosas nesses pacientes é crucial para o diagnóstico e a intervenção precoces.

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Section: Discussionunclassified

Avaliação das manifestações dermatológicas em pacientes com doença renal crônica em um serviço de hemodiálise no Distrito Federal

Cavalcanti,

Thomé,

Name

2024

RSD

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“…Skin is the largest organ that can reflect systemic conditions due to abnormalities in internal organs, including kidney disorders (Chanda, Chintagunta, and Arakkal, 2017). Skin disorders in chronic kidney disease (CKD) are common, with a prevalence of 50-100% (Chanda, Chintagunta, and Arakkal, 2017;Raspha et al, 2018;Adejumo et al, 2019). In the last several decades, the prevalence and incidence of chronic kidney disease (CKD) have increased.…”

Section: Introductionmentioning

confidence: 99%

“…In the last several decades, the prevalence and incidence of chronic kidney disease (CKD) have increased. It has become a global health problem in developed and developing countries (Prodjosudjadi and Suhardjono, 2009;Adejumo et al, 2019). The prevalence of CKD in Indonesia has increased by 1.8% from 2013 to 2018, with hypertension as the leading cause (Laporan Nasional RISKESDAS, 2018).…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Manifestations in End-Stage Renal Disease (ESRD)

Rahmatika,

Setyaningrum,

Sawitri

et al. 2024

Qanun Medika

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Skin can reflect systemic conditions due to abnormalities in internal organs, including kidney disorders. Cutaneous manifestations are common in patients with end-stage renal disease (ESRD). It can be severe and negatively impact a patient's quality of life. Clinicians can effectively manage ESRD by closely examining the patient's skin and nails, improving the patient's quality of life, and reducing mortality and morbidity. Clinicians can be more aware of ESRD by examining the patient's skin and nails closely so proper management can be performed and the patient's quality of life can be improved. This review aims to increase understanding of common cutaneous manifestations in ESRD for early recognition and better management. Cutaneous manifestations in ESRD are divided into specific and nonspecific manifestations. Specific manifestations include acquired perforating dermatosis (APD), bullous disease (porphyria cutanea tarda and pseudoporphyria), metastatic calcification (calcinosis cutis and calcific uremic arteriolopathy), and nephrogenic systemic fibrosis. Nonspecific manifestations include pruritus, xerosis, skin pigmentation changes, nail disorders, purpura, hair disorders, oral mucosal changes, skin infections, and other skin manifestations. These manifestations range from benign and asymptomatic to serious conditions that negatively impact life quality. In conclusion, Early detection and treatment of cutaneous manifestations in patients with ESRD are crucial for reducing morbidity and mortality and also improving patients' quality of life.

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“…The pathogenesis has not yet been clarified, but several pathogenic factors are discussed, for example, dysfunction of parathyroid hormone metabolism, calcium, and magnesium levels, as well as direct histamine release. Next to pruritus, a variety of skin symptoms appear, which are burdensome for people affected [5,[10][11][12]. In addition, patient's health-related quality of life in uraemic pruritus is impaired due to physical and emotional burden including changes in mood, a lack of sleep, and impairments in the social environment [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, pruritus is an important and burdensome feature of CKD including dialysis. It is evident that such health-related quality of life burden results from both the pruritus condition as well as from the overall underlying disease and its treatment [12,14,15]. For this, the disease burden cannot be directly related to pruritus per se.…”

Section: Introductionmentioning

confidence: 99%

Skin Lesions, Skin Care, and Characteristics of Pruritus in Patients Undergoing Haemodialysis

Sommer¹,

Ständer²,

Augustin³

2021

Skin Pharmacol Physiol

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Introduction: Pruritus has been shown to be a common and burdensome complaint in the general population. In some diseases, there is an even higher rate and intensity of pruritus such as in chronic kidney diseases. In particular, patients requiring dialysis commonly suffer from pruritus with proportions between 22.0 and 90.0%. Few data on the characteristics and burden of such pruritus have been published. Therefore, the aim of this study was to investigate the extent and profiles of pruritus in such patients related to skin lesions and care. Methods: A non-interventional cross-sectional study in 14 centres for haemodialysis across Germany was conducted. The survey explored the prevalence, severity, and resulting burden of pruritus and skin lesions. Results: In total, 302 patients with uraemia (56.5% male, mean age 66.0 ± 14.4 years, mean duration of dialysis 3.9 ± 4.8 years) were included. Skin lesions appeared since start of dialysis in 50.0% of patients, with xerosis (94.7%) and desquamation (25.8%) being the most frequent and disturbing findings. Pruritus was reported by 60.9% of patients undergoing dialysis with a current mean numerical rating scale of 5.1 ± 2.4 occurring most frequently in the back, legs, and arms. About 89.0% of patients with xerosis and 69.0% with desquamation reported self-medication. However, only 40.0% and 28.0% sought medical help, respectively, indicating a remarkable lack of healthcare. Discussion: The current data suggest a more intensive focus on the skin symptoms and signs related to uraemia in the patients with dialysis and thus underline claims from a previous German large-scale study. Recommendations for early treatment and prevention of skin lesions in dialysis patients should be developed. Further research should be conducted focusing on recognizing subgroups of patients of particular vulnerability to pruritus and skin lesions, which may facilitate identifying patients at risk in an early moment. Moreover, a more specific tool for screening of skin lesions as well as pruritus may be useful since the existing instruments lack such specificity.

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Skin changes and dermatological life quality index in chronic kidney disease patients in a tertiary hospital in Southern Nigeria

Cited by 9 publications

References 0 publications

Avaliação das manifestações dermatológicas em pacientes com doença renal crônica em um serviço de hemodiálise no Distrito Federal

Avaliação das manifestações dermatológicas em pacientes com doença renal crônica em um serviço de hemodiálise no Distrito Federal

Cutaneous Manifestations in End-Stage Renal Disease (ESRD)

Skin Lesions, Skin Care, and Characteristics of Pruritus in Patients Undergoing Haemodialysis

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