Skin Fillers

Kusin, Shana; Lippitz, Jonathan

doi:10.1016/j.disamonth.2009.01.002

Cited by 15 publications

(12 citation statements)

References 61 publications

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“…The majority of microspheres obtained after solvent removal were smooth and between 20–60 m, meeting the criteria for bulking agents (Fig. 1C) [3, 27–29]. In addition to being FDA approved and used for numerous TE applications [36–38], PLGA was selected because of its biodegradable nature.…”

Section: Resultsmentioning

confidence: 99%

“…Particle geometry and size have also been extensively studied and generally smooth surfaces and a smaller area for a given volume induce a macrophage mediated constructive collagen bulking and although irregularly shaped particles do result in inflammation, they elicit a macrophage mediated chronic healing response leading to inconsistent collagen distribution [4, 27, 28]. Microsphere size should be small enough for injectable delivery and to prevent fibrous capsule isolation (typically < ~100 m), but large enough to avoid macrophage phagocytosis (> ~10 m), which can amplify an undesired chronic inflammatory response [3, 6, 7, 27, 29]. …”

Section: Introductionmentioning

confidence: 99%

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Tunable hydrogel-microsphere composites that modulate local inflammation and collagen bulking

et al. 2012

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Injectable biomaterials alone may alter local tissue responses, including inflammatory cascades and matrix production (e.g., stimulatory dermal fillers are used as volumizing agents that induce collagen production). To expand upon the available material compositions and timing of presentation, a tunable hyaluronic acid (HA) and poly(lactide-co-glycolide) (PLGA) microsphere composite system was formulated and assessed in subcutaneous and cardiac tissues. HA functionalized with hydroxyethyl methacrylate (HeMA) was used as a precursor to injectable and degradable hydrogels that carry PLGA microspheres (~50 m diameter) to tissues, where the HA hydrogel degradation (~20 or 70 days) and quantity of PLGA microspheres (0–300 mg/ml) are readily varied. When implanted subcutaneously, faster hydrogel degradation and more microspheres (e.g., 75mg/mL) generally induced more rapid tissue and cellular interactions and a greater macrophage response. In cardiac applications, tissue bulking may be useful to alter stress profiles and to stabilize the tissue after infarction, limiting left ventricular (LV) remodeling. When fast degrading HeMA-HA hydrogels containing 75 mg/mL microspheres were injected into infarcted tissue in sheep, LV dilation was limited and the thickness of the myocardial wall and the presence of vessels in the apical infarct region were increased ~35% and ~60%, respectively, compared to empty hydrogels. Both groups decreased volume changes and infarct areas at 8 weeks, compared to untreated controls. This work illustrates the importance of material design in expanding the application of tissue bulking composites to a range of biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tunable hydrogel-microsphere composites that modulate local inflammation and collagen bulking

et al. 2012

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“…Polymethylmethacrylate represents, at the moment, the most commonly chosen option for cosmetic filling with permanent materials. It is known that during the initial period, from four to 6 weeks after injection of the product, the PMMA spheres provoke a foreign‐body reaction, being later encapsulated by the collagen fibres in the tissue, thus preventing material migration 36 .…”

Section: Tissue Responsementioning

confidence: 99%

“…Polymethylmethacrylate has been usually recommended for lipodystrophy correction because of the use of antiretroviral drugs (ARV) in HIV-positive patients 51 , facial contour 1,18,36,52 , glabellar lines 52,53 , nasolabial folds 1,18,36,52 , filling of the malar region 53,54 ; wrinkles correction 18,36,53,55 and lip filling 18,36,[53][54][55] .…”

Section: Pmma Indicationsmentioning

confidence: 99%

“…This product is obtained through the combination of liquid collagen and solid PMMA micro-spheres, being used for filling soft tissues in aesthetic surgery, known as bioplasty, a non-incisional and minimally invasive method [25][26][27] . The injectable form is composed of dispersed microspheres in carboxymethylcellulose colloid, applied for wrinkle reduction, volume increase and improvement of the facial contours, among other surgical applications 18,[20][21][22][23][27][28][29][30][31][32][33][34][35][36] .…”

Section: Introductionmentioning

confidence: 99%

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Use of polymethylmethacrylate as permanent filling agent in the jaw, mouth and face regions – implications for dental practice

et al. 2011

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Use of polymethylmethacrylate as permanent filling agent in the jaw, mouth and face regionsimplications for dental practiceObjectives: This article is a review of PMMA focusing on its properties, indications, contra-indications and adverse effects. Background: The search to remain young is a constant attitude among Brazilians. The low cost of filling agents have stimulated its indiscriminate use, especially the bioplasty (non-incisional method). Polymethylmethacrylate (PMMA) is the cosmetic filling agent of choice, because of its low cost, easy access and simple application technique. The impact on dentistry and orofacial medicine needs further awareness. Conclusion: The article aims to draw the attention of odontology and medical professionals to the product's applicability and its possible complications.

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Ultrasound detection of cosmic filler injection of lips in camel beauty pageants: first report in veterinary medicine

Tadjine

Al-Hawas

2021

Trop Anim Health Prod

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Skin Fillers

Cited by 15 publications

References 61 publications

Tunable hydrogel-microsphere composites that modulate local inflammation and collagen bulking

Tunable hydrogel-microsphere composites that modulate local inflammation and collagen bulking

Use of polymethylmethacrylate as permanent filling agent in the jaw, mouth and face regions – implications for dental practice

Ultrasound detection of cosmic filler injection of lips in camel beauty pageants: first report in veterinary medicine

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