Skin: Histology and Physiology of Wound Healing

Gantwerker, Eric; Hom, David B.

doi:10.1016/j.fsc.2011.06.009

Cited by 185 publications

(159 citation statements)

References 19 publications

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“…Immediately after injury, the blood clots forms a scab that protects the injured area 2 . The consequent release of chemical mediators induces an acute inflammatory response characterized by the presence of neutrophils, followed later by macrophages and lymphocytes 2,[6][7][8] . The activation, proliferation and differentiation of undifferentiated mesenchymal cells give origin to activated fibroblasts present in the granulation tissue [6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

“…The consequent release of chemical mediators induces an acute inflammatory response characterized by the presence of neutrophils, followed later by macrophages and lymphocytes 2,[6][7][8] . The activation, proliferation and differentiation of undifferentiated mesenchymal cells give origin to activated fibroblasts present in the granulation tissue [6][7][8] . These fibroblasts become bipolar and secrete extracellular matrix components, including fibronectin, proteoglycans and types I and III collagen fibers [6][7][8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

“…The activation, proliferation and differentiation of undifferentiated mesenchymal cells give origin to activated fibroblasts present in the granulation tissue [6][7][8] . These fibroblasts become bipolar and secrete extracellular matrix components, including fibronectin, proteoglycans and types I and III collagen fibers [6][7][8][9][10] . Collagen synthesis is induced hours after injury, but only becomes significant after one week and can continue for 12 to 18 months [9][10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

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Effect of Brassica oleracea in rats skin wound healing

et al. 2013

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PURPOSE:To investigate the effect of Brassica oleracea herbal balsam on the healing of skin wounds in rats. METHODS:Twenty four rats (Wistar, 60 days, 250 g) were divided into four groups: untreated animals (C) and treated with the ointment (T), subdivided into two experimental times (seven and 16 days). A 3cm 2 skin wound was made in the back of all animals.100 ml of the Brassica oleracea was applied twice a day in T group. Biometric analysis was made with images captured at one, four, seven, ten, 13, and 16 days. At seven and 16 days, animals of each group were euthanized. The wound area removed was processed for histological and histomorphometric analysis to quantify birefringent collagen fibers. Statistical analysis was made considering p < 0.05 as significant. RESULTS:Biometric analysis revealed no significant differences between groups in both experimental times studied. However, histomorphometric analysis showed that the number of type I collagen fibers was significantly higher in the specimens of the group T16 compared to the other groups. CONCLUSION:Brassica oleracea accelerated the wound healing process increasing the number of type I collagen fibers and the maturity of the newly formed tissue.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Brassica oleracea in rats skin wound healing

et al. 2013

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“…This is not surprising given our prior base of knowledge regarding the effect of skin-closure tension on wound healing. 15,16 Even when vascularity is adequate and short-term wound healing is uncomplicated in the immediate fill-combination-augmentation mastopexy procedure, excessive wound tension may result in hypertrophic or wide scars and patient dissatisfaction. In addition, far fewer minor wound-healing problems have resulted in simpler postoperative management and recovery of these patients with a reduction in anxiety for our patients and our staff.…”

Section: Discussionmentioning

confidence: 99%

The Delay Fill Technique: A Safer Approach to Combination Augmentation Mastopexy

Patronella

Mentz

Johnson-Alviza

2015

Seminars in Plastic Surgery

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).Combining mastopexy with augmentation is a technically demanding procedure, associated with relatively high revision rates and the potential for significant wound-healing complications that lead to poor results, high patient dissatisfaction, and litigation. 1-3 The combination of two procedures on the breast simultaneously makes the ultimate outcome less predictable as tissue compliance is subject to the competing forces of the implant expanding the soft tissue, while the skin excision and breast lift compresses it.This ultimately reduces vascularity to the skin flaps and the nipple-areolar complex (NAC), creating the potential for major wound-healing complications. In addition, as the implant settles and the skin envelope relaxes, there is a greater chance for recurrent ptosis, asymmetry, and implant malposition as compared with either procedure alone. In addition, in an effort to protect vascularity, there may be a morecautioned approach to skin flap dissection and lifting, creating a greater potential need for a secondary lift as follow-up of each patient progresses over enough time to allow soft tissuecompliance issues to manifest.Numerous references in the literature highlight the higher risk associated with this procedure in an effort to caution the plastic surgeon before proceeding with this procedure without due respect for the potential adverse consequences. [2][3][4] The cautionary language in publications such as "Augmentation/Mastopexy: Surgeon Beware" and "Secondary Mastopexy in the Augmented Patient: A Recipe for Disaster" is incisive and appropriate. 1,2In a candid 3-year review of 166 combined augmentation/ mastopexy cases, Spear reported a 17% complication rate in primary augmentation/mastopexy and a 23% complication rate in secondary augmentation/mastopexy. 5 In another study, Stevens found a 14.6% revision rate in 321 patients with most attributed to implant-related issues rather than soft tissue complications. 6 In a more recent study, Stevens reported a 16.9% revision rate in 615 patients evenly Keywords ► augmentation mastopexy ► delayed implant fill ► breast revision AbstractCombining breast augmentation with mastopexy is a challenging procedure that has a relatively high revision rate in the literature. Some surgeons prefer a two-stage procedure to avoid the potential for skin flap or nipple-areolar complex necrosis that can occur with a one-stage procedure. The authors compared 101 patients who had subpectoral breast augmentation with immediate implant fill and mastopexy with 203 patients who had subpectoral breast augmentation with delayed (10-14 days) implant fill and mastopexy. They found the revision rate for immediate implant fill was 24%; in the delayed implant fill group, the revision rate was 10.3%. Patients had soft tissuerelated complications in 16% of the immediate fill group and in 2% of the delayed fill group. Delaying implant fill in combined breast augmentation mastopexy significantly reduces the risk of soft tissue-related complications and revision procedures; the dela...

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“…After the first day, circulating monocytes transition to macrophages in the wound, releasing interleukin 1 and fibroblast growth factor, further exacerbating inflammation, promoting angiogenesis, and stimulating further chemotaxis of fibroblasts, keratinocytes, and endothelial cells. 4,5 During the proliferative phase, fibroblasts synthesize collagen and ground substance. They then cross-link and organize collagen molecules, contributing to wound tensile strength.…”

Section: Principles Of Normal Wound Healingmentioning

confidence: 99%

Managing severe burn injuries: challenges and solutions in complex and chronic wound care

Rogers¹,

Jeschke²

2016

CWCMR

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Encountered regularly by health care providers across both medical and surgical fields and an increasing socioeconomic burden globally, wound care is severely neglected. Practice is heavily influenced by anecdote rather than evidence-based protocols and industry-biased literature rather than robust randomized controlled trials. Burn units are well placed to address this considerable need, as a result of their infrastructure, their multispecialty staffing, and their need to evolve in light of the declining incidence of major burn injury in developed countries. The aim of this review is to evaluate some of the ideological and practical challenges facing wound practitioners and burn surgeons while managing chronic and complex wounds. It also includes an approach to wound assessment and how to conceptualize and implement dressing strategies and new and existing multimodal therapies.

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Skin: Histology and Physiology of Wound Healing

Cited by 185 publications

References 19 publications

Effect of Brassica oleracea in rats skin wound healing

Effect of Brassica oleracea in rats skin wound healing

The Delay Fill Technique: A Safer Approach to Combination Augmentation Mastopexy

Managing severe burn injuries: challenges and solutions in complex and chronic wound care

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