Skin Hydration Effects of Scale‐Up Fermented <i>Cyclopia intermedia</i> against Ultraviolet B‐Induced Damage in Keratinocyte Cells and Hairless Mice

Im, A‐Rang; Yeon, Sung Hum; Ji, Kon-Young; Son, Rak Ho; Um, Key An; Chae, Sungwook

doi:10.1155/2020/3121936

Cited by 8 publications

(8 citation statements)

References 37 publications

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“…The level of skin moisture was improved by 11.3% although individual variation and activities might have contributed to the statistical significance. TEWL is subjected to the integrity of the skin barrier and the hyaluronic acid content in ECM, which are affected by photoaging 34 . The topical application of caffeine has been proved to restore the skin barrier in adult males 35 .…”

Section: Resultsmentioning

confidence: 99%

“…TEWL is subjected to the integrity of the skin barrier and the hyaluronic acid content in ECM, which are affected by photoaging. 34 The topical application of caffeine has been proved to restore the skin barrier in adult males. 35 We propose that the obvious improvement of skin elasticity and brightness after 4 weeks of topical treatment might arise from the effective delivery of the bioactive compounds of CPS to the dermis, which negates the influence of elastase of skin.…”

Section: Skin Moisture Brightness and Elasticitymentioning

confidence: 99%

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Coffee pulp supplement affects antioxidant status and favors anti‐aging of skin in healthy subjects

Tseng

Liu

Chan

et al. 2021

J of Cosmetic Dermatology

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Background Coffee and coffee products are known potentially to reduce levels of oxidative stress biomarkers in humans. Objective This investigation evaluates the effects of coffee pulp extract as a functional supplement (in coffee pulp drink, CPD) and a cosmetic ingredient (coffee pulp serum, CPS). Patients/Methods The effects of CPD and CPS for anti‐oxidation and anti‐aging were investigated. Forty subjects were randomly allocated to CPD or placebo drink groups (50 ml of a CPD/placebo drink daily for 8 weeks for each subject), and another 40 subjects were recruited to CPS or placebo serum groups (about 3 ml of a CPS/placebo serum day and night/daily for 4 weeks for each subject) in a double‐blind study. Results The CPD and CPS (20%) can increase free radical scavenging activities by 93.3% and 85% (p < 0.001) for DPPH, 94.5% and 61.3% (p < 0.01) for ABTS·+, 43.8% and 15.3% (p < 0.05) for NO· than placebo. The inhibition of tyrosinase activity was increased by 91.6% and 51.0% (p < 0.05) after CPD and CPS application. The CPD comprehensively improved the moisture, brightness, elasticity, spotting, texture, and collagen content of skin for most subjects after 8 weeks, relative to the baseline without treatment (p < 0.05). After 4 weeks of CPS serum consumption, the brightness, elasticity, spotting, UV spots, and collagen content of skin were slightly better than those at week 0 (p < 0.05). Conclusions The daily consumption of coffee pulp extract products can slow the skin aging process and improve skin health.

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Section: Resultsmentioning

confidence: 99%

Section: Skin Moisture Brightness and Elasticitymentioning

confidence: 99%

Coffee pulp supplement affects antioxidant status and favors anti‐aging of skin in healthy subjects

Tseng

Liu

Chan

et al. 2021

J of Cosmetic Dermatology

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“…Moreover, a similar improvement was observed for wrinkle formation, epidermal thickening, erythema, hyperpigmentation, skin hydration, and TEWL in UVB-irradiated hairless mice after oral administration of Agastache rugosa [ 45 ]. Furthermore, several extracts, including the dietary enzyme-treated Hibiscus syriacus and Hochuekkito, ameliorated wrinkle formation, TEWL, stratum corneum (SC) hydration, and erythema index in hairless mice after UVB exposure [ 46 , 47 ]. Meanwhile, oral route and topical route are widely used as animal treatment methods to assess anti-photoaging effects of natural products.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Dipterocarpus tuberculatus with High Antioxidative Activity Against UV-Induced Photoaging of NHDF Cells and Nude Mice

et al. 2021

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To investigate the therapeutic effects of methanol extracts of Dipterocarpus tuberculatus Roxb. (MED) against UV-induced photoaging, we assessed for alterations in the antioxidant activity, anti-apoptotic effects, ECM modulation, skin appearances, and anti-inflammatory response in normal human dermal fibroblast (NHDF) cells and nude mice orally treated with MED. High levels of tannin content and high free radical scavenging activity to DPPH were determined in MED, while seven active components, namely, gallic acid, bergenin, ellagic acid, ε-viniferin, asiatic acid, oleanolic acid, and 2α-hydroxyursolic acid, were identified using LC–MS analyses. UV-induced alterations in the NO concentration, SOD activity, and Nrf2 expression were remarkably recovered in MED-treated NHDF cells. Moreover, the decreased number of apoptotic cells and G2/M phase arrest were observed in the UV + MED-treated groups. Similar recoveries were detected for β-galactosidase, MMP-2/9 expression, and intracellular elastase activity. Furthermore, MED treatment induced suppression of the COX-2-induced iNOS mediated pathway, expression of inflammatory cytokines, and inflammasome activation in UV-radiated NHDF cells. The anti-photoaging effects observed in NHDF cells were subsequently evaluated and validated in UV + MED-treated nude mice through skin phenotypes and histopathological structure analyses. Taken together, these results indicate that MED exerts therapeutic effects against UV-induced photoaging and has the potential for future development as a treatment for photoaging.

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“…UVB radiation is known to greatly alter skin characteristics by triggering physiological changes of skin surface properties, histological features, and moisture loss [ 25 , 26 ]. Moreover, skin photodamage has been shown by some researchers to be linked to epidermal thickening that commonly occurs in UVB-irradiated skin [ 27 , 28 ]. By contrast, in PG2- or PA-treated mice, no apparent skin dryness and skin desquamation were observed, while epidermal thickness and TEWL values decreased and stratum corneum water content increased.…”

Section: Discussionmentioning

confidence: 99%

Panax ginseng C. A. Meyer Phenolic Acid Extract Alleviates Ultraviolet B-Irradiation-Induced Photoaging in a Hairless Mouse Skin Photodamage Model

Jiang

Liu

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Here, we evaluated the in vivo skin-protective effects of topical applications of Panax ginseng C. A. Meyer extract (PG2) and its phenolic acid- (PA-) based components against UVB-induced skin photoaging. PG2 or PA applied to skin of hairless mice after UVB-irradiation alleviated UVB-induced effects observed in untreated skin, such as increased transepidermal water loss (TEWL), increased epidermal thickness, and decreased stratum corneum water content without affecting body weight. Moreover, PG2 and PA treatments countered reduced mRNA-level expression of genes encoding filaggrin (FLG), transglutaminase-1 (TGM1), and hyaluronan synthases (HAS1, HAS2, and HAS3) caused by UVB exposure and reduced UVB-induced collagen fiber degradation by inhibiting the expression of matrix metalloproteinase genes encoding MMP-1, MMP-2, and MMP-9. Meanwhile, topical treatments reduced cyclooxygenase-2 (COX-2) mRNA-level expression in photodamaged skin, leading to the inhibition of interleukin-1β (IL-1β) and interleukin-6 (IL-6) mRNA-level expression. Thus, ginseng phenolic acid-based preparations have potential value as topical treatments to protect skin against UVB-induced photoaging.

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Skin Hydration Effects of Scale‐Up Fermented Cyclopia intermedia against Ultraviolet B‐Induced Damage in Keratinocyte Cells and Hairless Mice

Cited by 8 publications

References 37 publications

Coffee pulp supplement affects antioxidant status and favors anti‐aging of skin in healthy subjects

Coffee pulp supplement affects antioxidant status and favors anti‐aging of skin in healthy subjects

Therapeutic Effects of Dipterocarpus tuberculatus with High Antioxidative Activity Against UV-Induced Photoaging of NHDF Cells and Nude Mice

Panax ginseng C. A. Meyer Phenolic Acid Extract Alleviates Ultraviolet B-Irradiation-Induced Photoaging in a Hairless Mouse Skin Photodamage Model

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