Skin Permeability to Oxygen and Hyperbaric Oxygen

Gruber, Ronald P.; Heitkamp, Dale H.; Billy, Lawrence J.; Amato, Joseph J.

doi:10.1001/archsurg.1970.01340250071015

Cited by 30 publications

(12 citation statements)

References 9 publications

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“…This finding indicated an absorption of oxygen through an ulceration without influencing the systemic capillary p02. Oxygen permeability of the skin is dependent upon skin thickness and oxygen pressure. Normal skin absorbs very little oxygen under ambient pressure.…”

Section: Resultsmentioning

confidence: 99%

Treatment of Ulcers on the Legs With Hyperbaric Oxygen

Fischer¹

1975

The Journal of Dermatologic Surgery and Oncology

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Section: Resultsmentioning

confidence: 99%

Treatment of Ulcers on the Legs With Hyperbaric Oxygen

Fischer¹

1975

The Journal of Dermatologic Surgery and Oncology

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“…The application of positive pressure oxygen to manage open wounds has been studied extensively and has demonstrated promising clinical results [20][21][22][23][24][25][26][27][28]. The systemic complications associated with the use of a full-body hyperbaric chamber have been overcome by the application of topical wound pure oxygen at an appropriate cycled pressure to only the specific wound site.…”

Section: Topical Wound Oxygenmentioning

confidence: 99%

Topical Wound Oxygen Versus Conventional Compression Dressings in the Management of Refractory Venous Ulcers

Sultan¹,

Tawfick²,

Kavanagh³

et al. 2016

Wound Healing - New Insights Into Ancient Challenges

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Topical wound oxygen (TWO 2 ) proposes an innovative therapy option in the management of refractory non-healing venous ulcers (RVU) that aims to accelerate wound healing. TWO 2 accelerates epithelialisation. This leads to the development of a higher tensile strength collagen, which lessens scarring and the risk of recurrence. Sixty-seven limbs with 67 ulcers were managed using TWO 2 therapy, and 65 limbs with 65 ulcers were managed using conventional compression dressings (CCD). The proportion of ulcers completely healed by 12 weeks was 76% in patients managed with TWO 2 , compared to 46% in patients managed with CCD (p < 0.0001). The mean reduction in ulcer surface area at 12 weeks was 96% in the TWO 2 therapy group, compared to 61% in patients managed with CCD. The median time to full ulcer healing was 57 days in the TWO 2 group, in contrast to 107 days in patients managed with CCD (p < 0.0001). TWO 2 patients had a significantly improved Quality-Adjusted Time Spent Without Symptoms of disease and Toxicity of treatment (Q-TWiST) compared to CCD patients, denoting an improved outcome (p < 0.0001). TWO 2 reduces the time needed for RVU healing and is successful in pain alleviation and MRSA elimination. TWO 2 therapy radically degrades recurrence rates. Utilising diffused oxygen raises the capillary partial pressure of oxygen (Po 2 ) levels at the wound site, stimulating epithelialisation, and granulation of new healthy tissue. Taking the social and individual aspects of chronic venous ulceration into account, the use of TWO 2 can provide an overwhelmingly improved quality of life for long-time sufferers of this debilitating disease.

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“…The thickness of the stratum corneum was estimated to average 12 mm. Gruber et al (1970) used full-thickness skin samples to demonstrate that gaseous oxygen can penetrate into live dermis taken from the abdomen [14]. Exposing samples to 100% gaseous oxygen at a pressure of 3 atms, oxygen could penetrate to 300-340 mm passing through the epidermis into the dermis.…”

Section: Measurements Of Topical Oxygenationmentioning

confidence: 99%