Topical Dissolved Oxygen Penetrates Skin: Model and Method

Roe, David F; Gibbins, Bruce L.; Ladizinsky, Daniel

doi:10.1016/j.jss.2009.10.039

Cited by 44 publications

(51 citation statements)

References 21 publications

(20 reference statements)

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“…Despite the advantages of debridement, adequate debridement must always precede the application of topical wound healing agents, dressings, or wound closure procedures. 1,6,7,9,10 We planned this study with the view to compare wound healing in diabetic patients with use of adjuvant TOPOX with conventional methods and conventional methods alone in our hospital. This study may provide recommendations to benefit patients regarding their early healing and decrease morbidity.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Wound Healing with and without Adjuvant Topical Oxygen Therapy in Infected Diabetic Wounds

Sultan¹,

Sultan²,

Mehmood³

et al. 2017

APMC

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Diabetes mellitus (D.M) is one of the main problems in health systems and a global public health threat that has increased dramatically over the past 2 decades. Patients with D.M are prone to multiple complications such as diabetic foot ulcer (DFU). Despite of the advantages of debridement, adequate debridement must always precede the application of topical wound healing agents, dressings or wound closure techniques. Objective: The objective of the study was to compare the efficacy of adjuvant topical oxygen therapy with conventional methods and conventional methods alone in management of infected diabetic wounds. Study Design: Randomized Control Trial. Setting: Surgical Unit III, Allied Hospital, Faisalabad. Period: 4 months from March to June 2017. Methodology: A total of 120 cases included in this study were admitted either through OPD or emergency ward. Group A (Topical oxygen therapy was given along with conventional methods). Group B (Only conventional methods of wound care were applied). All patients were given single dose IV antibiotic half an hour before induction of anesthesia. All diabetic patients were administered regular insulin to control blood glucose levels. Good debridement was done, removing all dead tissue. Simple available cellophane bag applied, sterilized with antiseptic solution, tailored according to size of affected part used tapped on open side of body of patient like tourniquet. 100% oxygen was given in bag with routinely available oxygen cylinder exposing whole affected part of body or limb. Oxygen in chamber was given for maximum one and a half hour twice daily in one sitting for 7-10 days. Gram positive, gram negative and anaerobic cover was given with antibiotics. Wound was washed daily with normal saline. After clinical improvement patient was discharged and called for follow up at outdoor on weekly basis initially and then fortnightly for 6 months. Results: Mean age was calculated as 49.56+7.02 and 49.11+6.59years in group A and B respectively. 53.33% (n=32) in group A and 58.33% (n=35) in group B were males, while 46.67% (n=28) in group A and 41.67% (n=25) in group B were females. Comparison shows that 46.67% (n=28) in group A and 26.67% (n=16) in group B had efficacy; p value was calculated as 0.02 showing a significant difference. Conclusion: Efficacy of adjuvant topical oxygen therapy with conventional methods is significantly higher when compared with conventional methods alone in management of infected diabetic wounds.

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Section: Discussionmentioning

confidence: 99%

Comparison of Wound Healing with and without Adjuvant Topical Oxygen Therapy in Infected Diabetic Wounds

Sultan¹,

Sultan²,

Mehmood³

et al. 2017

APMC

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show abstract

“…Microcapsules size and H 2 O 2 loading increases as the molecular weight of the PMMA increases. Controlled production of O 2 is achievable with H 2 O 2 -loaded PMMA microcapsules that can be used for topical oxygenation for a period of 24 h. A gram of dry microcapsules produces a total of 10-12 cc of O 2 in 24 h. This O 2 delivery rate is approximately one to two orders of magnitude higher than the typical skin O 2 consumption (Roe et al, 2010). The H 2 O 2 -loaded PMMA microcapsules also have potential applications as anti-microbial agents.…”

Section: Discussionmentioning

confidence: 99%

“…Oxygen plays multiple roles in wound healing including bacterial killing, promotion of wound resurfacing, proliferation of fibroblasts, etc. Recent studies have shown that topical oxygen delivery devices can effectively deliver oxygen into and through the viable human skin, which significantly enhances the wound healing rate (Roe et al, 2010). However, the foremost challenge in oxygen therapy is the delivery of oxygen in a defined rate for extended periods of time (Harrison et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Hydrogen peroxide filled poly(methyl methacrylate) microcapsules: Potential oxygen delivery materials

Mallepally

Parrish

Hugh

et al. 2014

International Journal of Pharmaceutics

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This paper describes the synthesis of H₂O₂-H₂O filled poly(methyl methacrylate) (PMMA) microcapsules as potential candidates for controlled O₂ delivery. The microcapsules are prepared by a water-in-oil solvent emulsion and evaporation method. The results of this study describe the effect of process parameters on the characteristics of the microcapsules and on their in vitro performance. The size of the microcapsules, as determined from scanning electron microscopy, ranges from ∼5 to 30 μm and the size distribution is narrow. The microcapsules exhibit an internal morphology with entrapped H₂O₂-H₂O droplets randomly distributed in the PMMA continuous phase. In vitro release studies of 4.5 wt% H₂O₂-loaded microcapsules show that ∼70% of the H₂O₂ releases in 24h. This corresponds to a total O₂ production of ∼12 cc/gram of dry microcapsules. Shelf-life studies show that the microcapsules retain ∼84 wt% of the initially loaded H₂O₂ after nine months storage at 2-8 °C, which is an attractive feature for clinical applications.

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“…One must consider the fundamental challenge of transforming topical gaseous oxygen to its dissolved form enabling the oxygen to be biologically available to cells. For example, it has been demonstrated recently that devices which deliver topical dissolved oxygen are more effective at delivering oxygen through viable skin samples than topical gaseous oxygen devices [38].…”

Section: Discussionmentioning

confidence: 99%

Effect of an oxygen pressure injection (OPI) device on the oxygen saturation of patients during dermatological methyl aminolevulinate photodynamic therapy

et al. 2012

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Methyl aminolevulinate photodynamic therapy (MAL-PDT) (a topical treatment used for a number of pre-cancerous skin conditions) utilizes the combined interaction of a photosensitizer (protoporphyrin IX (PpIX)), light of the appropriate wavelength and molecular oxygen to produce singlet oxygen and other reactive oxygen species which induce cell death. During treatment localized oxygen depletion occurs and is thought to contribute to decreased efficacy.The aim of this study was to investigate whether an oxygen pressure injection (OPI) device had an effect on localized oxygen saturation levels and/or PpIX fluorescence of skin lesions during MAL-PDT. This study employed an OPI device to apply oxygen under pressure to the skin lesions of patients undergoing standard MAL-PDT. Optical reflectance spectrometry and fluorescence imaging were used to non-invasively monitor the localized oxygen saturation and PpIX fluorescence of the treatment area respectively. No significant changes in oxygen saturation were observed when these data were combined for the group with OPI and compared to the group that received standard MAL-PDT without OPI. Additionally no significant difference in PpIX photobleaching or clinical outcome at three months between the groups of patients was observed although the group that received standard MAL-PDT demonstrated a significant increase (p<0.05) in PpIX fluorescence initially and both groups produced a significant decrease (p<0.05) after light irradiation. In conclusion, with this sample size this OPI device was not found to be an effective method with which to improve tissue oxygenation during MAL-PDT. Further investigation is therefore required to find a more effective method of MAL-PDT enhancement.3

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Topical Dissolved Oxygen Penetrates Skin: Model and Method

Cited by 44 publications

References 21 publications

Comparison of Wound Healing with and without Adjuvant Topical Oxygen Therapy in Infected Diabetic Wounds

Comparison of Wound Healing with and without Adjuvant Topical Oxygen Therapy in Infected Diabetic Wounds

Hydrogen peroxide filled poly(methyl methacrylate) microcapsules: Potential oxygen delivery materials

Effect of an oxygen pressure injection (OPI) device on the oxygen saturation of patients during dermatological methyl aminolevulinate photodynamic therapy

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