Skin pre‐ablation and laser assisted microjet injection for deep tissue penetration

Jang, Hun-jae; Yeo, S.; Yoh, Jack J.

doi:10.1002/lsm.22608

Cited by 7 publications

(3 citation statements)

References 22 publications

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“…Microjet velocities of 23.0 to 50.6 m/s provided effective delivery of epidermal growth factor and human growth hormone in porcine skin, as determined by gene expression of keratinocyte laminin and fibroblast elastin, respectively. A subsequent refinement of the procedure has involved a pre-ablation step prior to microjet generation, both achieved by the same laser [120]. The advantage is that pre-ablation is targeted to finite areas, with the microjet then bombarding those defined areas.…”

Section: Physical Enhancement Approachesmentioning

confidence: 99%

Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies

Benson

Grice

Mohammed

et al. 2019

CDD

230

124

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This overview on skin delivery considers the evolution of the principles of percutaneous absorption and skin products from ancient times to today. Over the ages, it has been recognised that products may be applied to the skin for either local or systemic effects. As our understanding of the anatomy and physiology of the skin has improved, this has facilitated the development of technologies to effectively and quantitatively deliver solutes across this barrier to specific target sites in the skin and beyond. We focus on these technologies and their role in skin delivery today and in the future.

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Section: Physical Enhancement Approachesmentioning

confidence: 99%

Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies

Benson

Grice

Mohammed

et al. 2019

CDD

230

124

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“…The jet injection systems that have been trialled for the delivery of dental local anaesthetic have all been driven by an uncontrollable energy source, such as the release of a compressed spring [8], [12], [16]. Recently, focus in the field of jet injection has moved to controllable devices driven by electric motors [17], piezoelectric actuators [18], laserinduced cavitation [19], [20], or controlled pneumatic sources [21]. These injectors are able to develop a wide range of precisely-controlled fluid pressures and are capable of adjusting pressure dynamically during the injection.…”

Section: Introductionmentioning

confidence: 99%

Controllable Jet Injection of Dental Local Anaesthetic

McKeage

Loch

Zwirner

et al. 2021

IEEE J. Transl. Eng. Health Med.

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Fear of dental procedures is a common barrier to effective dental care. A promising technique to overcome dental anxiety is needle-free jet injection, which involves delivering local anaesthetic as a high-speed jet capable of penetrating the oral mucosa without a needle. Previous efforts have used loud, uncontrolled injectors designed for transdermal delivery that have failed to achieve significant uptake in dental practice. Methods: In this work, we present and validate a controllable jet injection device driven by a silent electric motor for the delivery of dental local anaesthetic. The injector includes a novel tubular attachment at its distal end, which allows the delivery to be performed comfortably throughout the mouth. The expected pressure loss resulting from the use of this attachment is analysed. This analysis predicted that a 75 mm long tubular attachment of 0.53 mm radius would result in negligible pressure loss. To validate delivery in human tissue, the injection system was used to perform 18 injections into the mouths of two Thiel-embalmed human cadavers. These injections were visualised using cone-beam computed tomography (CBCT). Results: Benchtop testing of the prototype injector verified the expected pressure loss along the attachment. The CBCT scans demonstrated that the fluid was successfully delivered to the desired locations, adjacent to the root apex of the teeth, at every injection site. Conclusion: These outcomes validate the performance of this novel needle-free injector, demonstrating its potential as a tool to reduce dental anxiety.

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“…It is a minimally invasive surgical technique, which can deliver various molecules into the subdermis using a high‐speed liquid jet. This technology is expected to have various potentials including the ability to increase penetration efficiency by pre‐ablating the epidermis with fractional lasers with rotating beams . Initially, this technique was studied to replace traditional needles in situations that require the repeated delivery of macromolecules, such as growth hormone and insulin .…”

Section: Introductionmentioning

confidence: 99%

Needle‐free pneumatic injection device; histologic assessment using a rat model and parameter comparison in predicting collagen synthesis degree

et al. 2019

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Background: Needle-free pneumatic injections have been recently introduced to the field of dermatology to inject such substances as hyaluronic acid. However, data on the influence of various pneumatic injection parameters on collagen synthesis are lacking. Objective: Compare the effect of diameter, pressure, and volume of a pneumatic injection jet on collagen synthesis and fluid dispersion pattern using a rat model. Investigate if the total work force of the injection jet is useful in predicting the degree of collagen synthesis. Materials and Methods: We injected fluid with 1 mg/ml of hyaluronic concentration to adult rats. Different injection pressures and volumes were tested using devices with nozzles of different diameters. Collagen synthesis areas were then measured, and statistical analyses were performed. Results: The area of collagen fibers increased for up to two months. The injection pressure and volume did not correlate with the degree of collagen synthesis. The nozzle diameter showed a significant after two and four weeks of injection. The total work force correlated with collagen synthesis 2, 4, and 8 weeks post-injection. (P ¼ 0.043, 0.027, and 0.000, respectively). Conclusion: Collagen formation is more prominent 2 months post-hyaluronic acid injection than after 1 month when using a needle-free pneumatic injection device. The total work force, which is affected by both the nozzle diameter and injection pressure, can be helpful in predicting the degree of collagen synthesis. Lasers Surg. Med. 51:278-285, 2019.

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Skin pre‐ablation and laser assisted microjet injection for deep tissue penetration

Cited by 7 publications

References 22 publications

Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies

Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies

Controllable Jet Injection of Dental Local Anaesthetic

Needle‐free pneumatic injection device; histologic assessment using a rat model and parameter comparison in predicting collagen synthesis degree

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