Skin reactivity, basophil degranulation and IgE levels in ageing

Schwarzenbach, Hans-Rudolf; Nakagawa, Takemasa; Conroy, Mary Carol; Weck, A.L. de

doi:10.1111/j.1365-2222.1982.tb01645.x

Cited by 26 publications

(9 citation statements)

References 17 publications

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“…A trend toward decreased production of superoxide anions was also observed in eosinophils from old individuals, but eosinophil adhesion, chemotaxis, and number in the sputum were unchanged. Basophil degranulation was initially reported to be impaired in an aged cohort [72], while a later study found higher reactivity from basophils from old subjects for both the maximum proportion of anti-IgE-induced histamine release as well as sensitivity to a standard concentration of anti-IgE [73]. With the recent demonstration of roles for basophils in CD4 TH2 cell differentiation [74] and in enhancing humoral immune memory responses [75], studies in aging humans are needed to examine these newly discovered functions.…”

Section: Neutrophils Eosinophils and Basophilsmentioning

confidence: 99%

Human innate immunosenescence: causes and consequences for immunity in old age

Panda

Arjona

Sapey

et al. 2009

Trends in Immunology

418

290

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The past decade has seen an explosion in research focusing on innate immunity. Through a wide range of mechanisms including phagocytosis, intracellular killing, and activation of pro-inflammatory or antiviral cytokine production via pattern recognition receptors, the cells of the innate immune system initiate and support adaptive immunity. The effects of aging on innate immune responses remain incompletely understood, particularly in humans. Here, we review advances in the study of human immunosenescence in the diverse cells of the innate immune system, including neutrophils, monocytes, macrophages, NK and NKT cells, and dendritic cells—with a focus on consequences for the response to infection or vaccination in old age.

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Section: Neutrophils Eosinophils and Basophilsmentioning

confidence: 99%

Human innate immunosenescence: causes and consequences for immunity in old age

Panda

Arjona

Sapey

et al. 2009

Trends in Immunology

418

290

View full text Add to dashboard Cite

show abstract

“…The frequency of autoimmune diseases is augmented with age, too, accompanied by an increase in autoantibodies, which is, interestingly, not observed in centenarians [ 60 , 61 ]. On the other hand, specific IgE production decreases, reducing the risk for allergies [ 62 , 63 ].…”

Section: Reviewmentioning

confidence: 99%

The immune system and the impact of zinc during aging

2009

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The trace element zinc is essential for the immune system, and zinc deficiency affects multiple aspects of innate and adaptive immunity. There are remarkable parallels in the immunological changes during aging and zinc deficiency, including a reduction in the activity of the thymus and thymic hormones, a shift of the T helper cell balance toward T helper type 2 cells, decreased response to vaccination, and impaired functions of innate immune cells. Many studies confirm a decline of zinc levels with age. Most of these studies do not classify the majority of elderly as zinc deficient, but even marginal zinc deprivation can affect immune function. Consequently, oral zinc supplementation demonstrates the potential to improve immunity and efficiently downregulates chronic inflammatory responses in the elderly. These data indicate that a wide prevalence of marginal zinc deficiency in elderly people may contribute to immunosenescence.

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“…In addition, basophils express Toll-like receptor (TLR) 2 and TLR4, and respond to microbial ligands like peptidoglycan [ 13 ] and lipopolysaccharide (LPS) [ 14 ]. Histamine release and sensitivity of basophils from elderly were reported to be increased upon anti-immunoglobulin (Ig) E stimulation [ 15 ], but in a different study, no age-related difference was found in histamine release of human blood basophils upon anti-IgE or anti-IgG4 stimulation [ 16 ]. Basophil counts were not associated with frailty or mortality in elderly women [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Aged mice display altered numbers and phenotype of basophils, and bone marrow-derived basophil activation, with a limited role for aging-associated microbiota

et al. 2018

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BackgroundThe influence of age on basophils is poorly understood, as well as the effect of aging-associated microbiota on basophils. Therefore, we studied the influence of aging and aging-associated microbiota on basophil frequency and phenotype, and differentiation from basophil precursors.ResultsBasophils became more abundant in bone marrow (BM) and spleens of 19-month-old mice compared with 4-month-old mice. Aged basophils tended to express less CD200R3 and more CD123, both in BM and spleen. Differences in microbiota composition with aging were confirmed by 16S sequencing. Microbiota transfers from young and old mice to germ-free recipients revealed that CD11b tended to be lowered on splenic basophils by aging-associated microbiota. Furthermore, abundance of Alistipes, Oscillibacter, Bacteroidetes RC9 gut group, and S24–7 family positively correlated and CD123 expression, whereas Akkermansia abundance negatively correlated with basophils numbers.Subsequently, we purified FcεRIα+CD11c−CD117− BM-derived basophils and found that those from aged mice expressed lower levels of CD11b upon stimulation. Higher frequencies of IL-4+ basophils were generated from basophil precursors of aged mice, which could be reproduced in basophils derived from germ-free recipients of aging-associated microbiota.ConclusionsCollectively, these results show the influence of aging on basophils. Furthermore, this study shows that aging-associated microbiota altered activation of BM-derived basophils in a similar fashion as observed in BM-derived basophils from aged mice.

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Skin reactivity, basophil degranulation and IgE levels in ageing

Cited by 26 publications

References 17 publications

Human innate immunosenescence: causes and consequences for immunity in old age

Human innate immunosenescence: causes and consequences for immunity in old age

The immune system and the impact of zinc during aging

Aged mice display altered numbers and phenotype of basophils, and bone marrow-derived basophil activation, with a limited role for aging-associated microbiota

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