Skin Remodeling Using Hyaluronic Acid Filler Injections in Photo-Aged Faces

Abstract

Sustained clinical results for HA filler can be explained not only by the presence of HA gel on the dermis but also by the dermal remodeling induced by HA filler injected into the face.

An innovative method to quantitate tissue integration of hyaluronic acid‐based dermal fillers

“…Although filler injections have been available and widely used for aesthetic and corrective procedures for over 20 years, only some well‐documented in situ evaluations related to their histopathology are available . Most publications on the subject were focused on tissue reactions and longevity of the fillers.…”

“…Wanick et al evaluated the morphological changes in photo‐aged faces after intradermal injection of Juvederm Ultra plus XS, a HA‐filler. Biopsies of the preauricular region at 3 or 9 months were compared to pre‐test biopsies.…”

“…Although biointegration can be assessed by histology, only a limited number of publications describe accurate microscopic methods . To our knowledge, no quantitative approaches have been published that allow comparative studies on biointegration with robust statistical analyses.…”

Cross‐sectional study of the microbiological safety profile of reusing hyaluronic acid fillers

“…Esthetic procedures to improve volume loss and facial wrinkles, correct (atrophic, traumatic or acne) scars, and minimize lipodystrophies (inherent to medications and chronic diseases) are widely described in the literature, with facial filling being one of the most used treatments …”

“…In 2003, the first HA filler was approved in the USA, and since then, many products for this purpose have been developed. Currently, there are at least three manufacturers, with more than 12 HA‐based injectable agents, which differ in the degree and type of cross‐linking, HA concentration, and particle size that determine their physical properties (viscosity, lifting capacity, and duration of effect) …”