Skin test reactivity to histamine from infancy to old age

Skassa-Brociek, W.; Manderscheid, Jean-Claude; Michel, F.-B.; Bousquet, Jean

doi:10.1016/0091-6749(87)90292-2

Cited by 139 publications

(60 citation statements)

References 15 publications

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“…119 The prevalence of positive skin test results increases until the 2 nd decade, with a slow decline above the age of 60 years. 120 In children with manifest allergy, however, skin has similar reactivity from 1 year of age until puberty. 4 Nevertheless, SPT tests can be used in infants as young as 1 month, with a high degree of reliability, usually with more erythema than wheal reaction.…”

Section: Variability Factorsmentioning

confidence: 99%

Skin prick tests and allergy diagnosis

Antunes

Borrego

Romeira

et al. 2009

Allergologia et Immunopathologia

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Skin testing remains an essential diagnostic tool in modern allergy practice. A signifi cant variability has been reported regarding technical procedures, interpretation of results and documentation. This review has the aim of consolidating methodological recommendations through a critical analysis on past and recent data. This will allow a better understanding on skin prick test (SPT) history; technique; (contra-) indications; interpretation of results; diagnostic pitfalls; adverse reactions; and variability factors. Skin has an important physiological role in the internal balance homeostasis and constitutes a crucial barrier against external aggressions, with well-known immunological properties. 1 It has been used by allergists for decades as an easily assessed laboratory of the immunological status of the individual.The fi rst skin testing technique was developed by Charles H. Blackley in 1865, a Manchester homeopathic physician with allergic rhinitis. He abraded a quarter-inch area of his skin with a lancet and then applied grass pollen grains. 2 The so-called scratch test was later adopted by Schloss for the diagnosis of food allergy in children. 3 Epicutaneous tests can be divided into scratch tests and prick/puncture tests. The fi rst method, proposed by Blackley 2 , implied a linear scratch without drawing blood and could either be performed fi rst, with the extract then dropped on the abraded skin, or be made through a drop of extract. 4 Although it was used extensively in the past, this technique became progressively obsolete due to patient discomfort, poor reproducibility, possible residual lesions and newer and innocuous procedures. 4 Therefore, scratch test is mentioned here for historical purposes only. It was Sir Thomas Lewis who, in 1924, fi rst applied skin prick tests (SPT). 5 Nevertheless, their generalised use in clinical practice only became a reality about 30 years ago, as a result of technique modifi cations proposed by Pepys. 6 For the purpose of this review and for easier comprehension, skin testing will be referred interchangeably as SPT, whatever device is used for its application.In 1966, Ishizaka's work on immunoglobulin E (IgE) and immediate hypersensitivity reactions 7 established the scientifi c corpus to what was done till then on a strictly empiric basis.As written by Dr Walzer in 1974, "the fact that skin testing has not turned out to be a simple and completely reliable technique does not detract from the fact that, when it is intelligently and skilfully performed, it remains the most effective diagnostic procedure in reaginic allergic disorders". 8 The reliability of skin testing and proper documentation of test results are essential in allergy practice. A recent survey to all physician members and fellows of the American College of Allergy, Asthma and Immunology practicing in the

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Section: Variability Factorsmentioning

confidence: 99%

Skin prick tests and allergy diagnosis

Antunes

Borrego

Romeira

et al. 2009

Allergologia et Immunopathologia

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“…Возрастных ограничений для проведения кожного тестирования не существует [22]. Установлено, что кожа детей уже с рождения чувствитель-на к гистамину, и эта чувствительность с возрастом увели-чивается [23]. Противопоказаниями к проведению кож-ного тестирования являются: обострение аллергического заболевания, острые инфекции, хронические болезни в стадии декомпенсации, беременность, туберкулезный процесс любой локализации в период обострения, пси-хические заболевания в период обострения, системные заболевания соединительной ткани, злокачественные заболевания.…”

Section: анамнез заболевания в диагностике пищевой непереносимостиunclassified

Diagnosis of Allergic and Nonallergic Food Intolerance in Children

Чебуркин¹

2013

Vopr. sovr. pediatr.

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Тщательное изучение спектра непереносимо-сти чрезвычайно важно, поскольку ошибка приво-дит, с одной стороны, к неоправданному ограниче-нию употребляемых продуктов, с другой -вследствие ошибочной диагностики у больного могут возникнуть серьезные реакции на якобы неаллергенный продукт. Большинство побочных реакций на продукты питания педиатры связывают с пищевой аллергией. Вместе с тем истинные аллергические реакции на пищу (под аллергическими подразумевают IgE-опосредованные процессы) встречаются только у 6-7% детей в возрасте до 3 лет и 4% детей и взрослых в целом [1]. К ним отно-сятся болезни:кожи -атопический дерматит, крапивница, отек • Квинке, контактный дерматит (немедленного типа);

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“…En este estudio no se encontró aumento de la respuesta a la histamina con la edad, tal como fue descrito por Menardo et al, utilizando la misma concentración de histamina (10 mg/ml), los que comunicaron un aumento significativo de la respuesta entre el grupo 0-3 meses y 3-6 meses, con estabilización hasta los 2 años y diferencia entre el segundo año de vida y los adultos 7 . Skassa-Brociek y cols, utilizaron histamina 27 mg/ml y obtuvieron resultados semejantes a los del presente estudio, con incrementos no significativos entre grupos etarios de 0-3 años y 4-5 años, también entre 6-9 años y 10-14 años 8 .…”

Section: A R T í C U L O D E I N V E S T I G a C I ó Nunclassified

“…La gran mayoría de los estudios han confirmado la utilidad de PCHI en niños, adolescentes e incluso en lactantes, aunque la reactividad a histamina es menor en población infantil comparada con adultos 7,8 . El mejor conocimiento de la historia natural de la enfermedad alérgica ha permitido demostrar una progresión desde la aparición de sensibilización asociada a una respuesta IgE, a la presencia de síntomas clínicos en distintos órganos y sistemas (marcha alérgica) 9,10 .…”

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Pruebas cutáneas de hipersensibilidad inmediata en una población pediátrica seleccionada

et al. 2005

Rev. méd. Chile

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Background: Skin prick test (SPT) of immediate hypersensitivity is a main instrument in the diagnosis G1, 39% in GII and 65% in GIII (p <0.001). The predominant allergens for each group were dust mites (Dermatophagoides pteronissinus and farinae). Conclusions: SPT was useful when used on a selected pediatric population. The frequency of sensitization increased significantly with age. However, more than one third of children between 2 and 4 years of age tested positive to one or more allergen, demonstrating its applicability in this age group (Rev Méd Chile 2005; 133: 195-201).

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Skin test reactivity to histamine from infancy to old age

Cited by 139 publications

References 15 publications

Skin prick tests and allergy diagnosis

Skin prick tests and allergy diagnosis

Diagnosis of Allergic and Nonallergic Food Intolerance in Children

Pruebas cutáneas de hipersensibilidad inmediata en una población pediátrica seleccionada

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