Sleep architecture and obstructive sleep apnea in obese children with and without metabolic syndrome: a case control study

Jalilolghadr, Shabnam; Yazdi, Zohreh; Mahram, Manoochehr; Babaei, Farkhondeh; Esmailzadehha, Neda; Nozari, Hoormehr; Saffari, Fatemeh

doi:10.1007/s11325-015-1291-y

Cited by 18 publications

(14 citation statements)

References 24 publications

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“…This study also found that the frequency of respiratory events, the degree of oxyhemoglobin saturation, and sleep efficiency were all associated with an increased MetS risk. A more recent case–control study of obese children found that OSA was more common in those with vs without the MetS 315. A study of 104 obese children and adolescents, of whom 58% were prepubertal, found an association between oxyhemoglobin desaturation measures and MetS risk 314.…”

Section: Obstructive Sleep Apnea and Cardiometabolic Riskmentioning

confidence: 99%

Role of sleep quality in the metabolic syndrome

Koren¹,

Dumin²,

Gozal³

2016

DMSO

150

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Emerging evidence has assigned an important role to sleep as a modulator of metabolic homeostasis. The impact of variations in sleep duration, sleep-disordered breathing, and chronotype to cardiometabolic function encompasses a wide array of perturbations spanning from obesity, insulin resistance, type 2 diabetes, the metabolic syndrome, and cardiovascular disease risk and mortality in both adults and children. Here, we critically and extensively review the published literature on such important issues and provide a comprehensive overview of the most salient pathophysiologic pathways underlying the links between sleep, sleep disorders, and cardiometabolic functioning.

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Section: Obstructive Sleep Apnea and Cardiometabolic Riskmentioning

confidence: 99%

Role of sleep quality in the metabolic syndrome

Koren¹,

Dumin²,

Gozal³

2016

DMSO

150

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“…An excess in weight is more crucial for OSA than either age or gender[ 37 , 38 ]. For every percent in weight reduction, there is a 3% reduction in the AHI[ 27 , 39 ].…”

Section: Correlations Between Ms and Osamentioning

confidence: 99%

Correlation between metabolic syndrome and sleep apnea

Castañeda¹,

Jauregui-Maldonado²,

Ratnani

et al. 2018

WJD

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The so-called “metabolic syndrome” (MS), constitutes a cluster of metabolic and cardiovascular abnormalities, including fasting glucose, blood pressure, triglycerides, high density lipoprotein cholesterol (HDL-C), and waist circumference that arise from insulin resistance. Obstructive sleep apnea (OSA) syndrome is characterized by recurrent episodes of partial or complete obstruction of the upper airway, involving cessation or significant decreased airflow, with intermittent hypoxemia, frequent arousals from sleep and recurrent oxyhemoglobin desaturations that interfere with normal sleep patterns generating difficulty falling asleep, unrefreshing sleep and loud snoring. The relation between these two entities is known as “Syndrome Z”, and there is no question about the impact of these risk factors on health and disease. This clinical condition presents a growing epidemic Worldwide, affecting approximately 60% of the general population with both MS and OSA due to the constant increase of body mass index in humans. This article presents evidence-based data that focuses on the direct relationship between MS and OSA.

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“…Obesity is a risk factor for both the metabolic syndrome and SDB. Growing evidence suggests that OSAS is a risk factor for the metabolic syndrome in children and adolescents, independent of obesity . A cross‐sectional study of 270 adolescents reported a 6.5‐fold increased risk for the metabolic syndrome among participants with OSAS .…”

Section: Which Co‐existing Conditions May Improve When Treatment For mentioning

confidence: 99%

“…Growing evidence suggests that OSAS is a risk factor for the metabolic syndrome in children and adolescents, independent of obesity. [99][100][101] A crosssectional study of 270 adolescents reported a 6.5-fold increased risk for the metabolic syndrome among participants with OSAS. 102 However, treatment of OSAS by adenotonsillectomy has had variable results on metabolic parameters.…”

Section: Metabolic Syndromementioning

confidence: 99%

When and why to treat the child who snores?

Tan

Álvarez

Tsaoussoglou

et al. 2016

Pediatric Pulmonology

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Obstructive sleep-disordered breathing (SDB) can result in cardiovascular and neurocognitive morbidity as well as adversely affect behavior, growth, quality of life, and nocturnal continence. This article summarizes the latest evidence regarding the morbidity related to obstructive SDB, commenting on the impact of severity of obstruction, that is, the difference in effects seen of moderate to severe obstructive sleep apnea syndrome (OSAS) compared to those of mild OSAS or primary snoring. The impact of therapy is discussed, focusing on which children are likely to benefit from treatment interventions; namely those with moderate or severe OSAS irrespective of the presence of morbidity, children with mild OSAS with associated morbidity or predictors of SDB persistence such as obesity, and children with complex conditions accompanied by upper airway obstruction like craniosynostosis and Prader-Willi syndrome. The co-existing conditions which may improve when treatment for obstructive SDB is offered are reviewed, while the clinical parameters associated with spontaneous improvement or resolution of obstructive SDB are discussed. The intention being to enable clinicians to make informed decisions on who should be treated, when and why. Pediatr Pulmonol. 2017;52:399-412. © 2016 Wiley Periodicals, Inc.

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Sleep architecture and obstructive sleep apnea in obese children with and without metabolic syndrome: a case control study

Abstract: Obese children with metabolic syndrome had increased WASO, N1 sleep stage, and severe OSA. But the results regarding sleep architecture are most likely a direct result of OSA severity. More longitudinal studies are needed to confirm the association of metabolic syndrome and OSA.

Cited by 18 publications

References 24 publications

Role of sleep quality in the metabolic syndrome

Role of sleep quality in the metabolic syndrome

Correlation between metabolic syndrome and sleep apnea

When and why to treat the child who snores?

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