Sleep/Wake Patterns of Individuals With Advanced Cancer Measured by Ambulatory Polysomnography

Parker, Kathy P.; Bliwise, Donald L.; Ribeiro, Maria H.L.; Jain, Sanjay; Vena, Catherine; Kohles-Baker, Mary Kay; Rogatko, André; Xu, Zhiheng; Harris, Wayne

doi:10.1200/jco.2007.12.2135

Cited by 103 publications

(71 citation statements)

References 49 publications

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“…Cancer patients take longer time to fall asleep, wake up more often, spend more time in bed and nap more frequently than healthy individuals [32,33] . On the other hand, genetic, environmental or behavioral factors may favor circadian disruption, predisposing patients to tumor development [34] .…”

Section: Discussionmentioning

confidence: 99%

Association between PER3 length polymorphism and onco-hematological diseases and its influences on fatigue on awakening in patients

et al. 2015

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Circadian clock gene PER3 and its length polymorphism may have a role in oncogenesis as clock genes act as key regulators of cell cycle and DNA repair pathways. The polymorphism may affect the condition of patients who show disrupted circadian rhythm due to tumor development. The aim was to assess the association between PER3 polymorphism and onco-hematological diseases, and analyze whether this variant has an impact on patient's functionality. We conducted a case-control study on 125 patients with onco-hematological diseases and 310 control patients. PER3 allelic variants were detected by using polymerase chain reaction. Sociodemographic data and information on patient's habits and functionality were obtained through questionnaire. Genotypes 4/5 + 5/5 showed an odd ratio (OR) = 1.39, with no statistical significance. However, those genotypes were associated with a two-fold increase in the risk of acute/chronic lymphoblastic/myeloblastic leukemia, taken all together. The occurrence of "changes in humor during last two months" was significantly associated with onco-hematological diseases. "Fatigue on awakening" and "self-reported snore" were associated with cases carrying the 4/5 or 5/5 genotypes. The results suggested that PER3 polymorphism may have a role in the risk of leukemia, and might be a possible marker for individual differences in susceptibility to sleep disruption. This work provides insights for the identification of individuals at high risk of cancer, and those who are more susceptible to circadian disruption, which may decrease the physiological defenses against the tumor. he circadian system regulates metabolism and energy homeostasis on a daily basis in order to maintain vital processes and prepare the organism to respond to predictable/daily environmental conditions [1] . Accordingly, most of the mammalian physiology is regulated at some points by the main circadian clock which is located at the hypothalamic suprachiasmatic nuclei (SCN). Circadian coordination is known to be T

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Section: Discussionmentioning

confidence: 99%

Association between PER3 length polymorphism and onco-hematological diseases and its influences on fatigue on awakening in patients

et al. 2015

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“…Berger et al also noted substantial evidence of circadian disruption in that sample, suggesting that patients diagnosed with these types of cancer experience lack of distinction between nighttime and daytime in their activities 6 . This phenomenon was previously described in patients with advanced cancers where substantial amount of time spent asleep during the day and awake during the night effectively blurs the line between day and nighttime [7][8][9] . The observed association between altered rest-activity rhythm and subjectively-reported sleep problems in two independent cohorts of patients with metastatic colorectal cancer 10,11 further supported the hypothesis that disruption of circadian rhythms in cancer patients plays a role in the occurrence of sleep problems.…”

Section: Introductionmentioning

confidence: 87%

Subjective sleep and overall survival in chemotherapy-naïve patients with metastatic colorectal cancer

et al. 2015

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Oxana. (2015) Subjective sleep and overall survival in chemotherapy-naïve patients with metastatic colorectal cancer. Sleep Medicine, 16 (3). pp. 391-398. Permanent WRAP URL:http://wrap.warwick.ac.uk/85120 Copyright and reuse:The Warwick Research Archive Portal (WRAP) makes this work by researchers of the University of Warwick available open access under the following conditions. Copyright © and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable the material made available in WRAP has been checked for eligibility before being made available.Copies of full items can be used for personal research or study, educational, or not-for-profit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. A note on versions:The version presented here may differ from the published version or, version of record, if you wish to cite this item you are advised to consult the publisher's version. Please see the 'permanent WRAP url' above for details on accessing the published version and note that access may require a subscription.

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“…Individuals with cancer may be particularly vulnerable to sleep-related problems [1][2][3]. Sleep-related difficulties in cancer patients have been linked to poorer quality of life [1,4], fatigue, and distress [5], as well as disruption in neuroendocrine and immune factors associated with tumor progression [6].…”

Section: Introductionmentioning

confidence: 99%

“…Sleep-related difficulties in cancer patients have been linked to poorer quality of life [1,4], fatigue, and distress [5], as well as disruption in neuroendocrine and immune factors associated with tumor progression [6]. Changes in daily routines, physical pain, and treatment-related side effects may be just some of the factors contributing to poor sleep among cancer patients, and recent findings suggest that men with cancer may be particularly vulnerable to disruption in sleep/wake patterns [1]. Yet, little is known about the influence of psychological factors on sleep in the context of chronic illness.…”

Section: Introductionmentioning

confidence: 99%

Coping Style and Sleep Quality in Men with Cancer

Hoyt

Ph.D.²,

Epstein

et al. 2009

ann. behav. med.

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Background Few studies have characterized the effects of cancer diagnosis and treatment on sleep quality in men with cancer, and even fewer have identified mediators between psychosocial factors and physical symptoms. It has been debated whether active, approach-oriented, coping behaviors or more passive, avoidance-oriented, coping behaviors are more important to the preservation of sleep quality. Purpose This study tested the impact of coping style (i.e., approach vs. avoidance) on sleep quality and depressive symptoms and intrusive thoughts as putative mediators. Methods Utilizing a longitudinal design, men with cancer (N=55) were assessed at study entry (T1) and again 6 months later (T2). Two indicators of sleep quality were assessed: severity of sleep disturbance symptoms and resulting interference with daily functioning from sleep problems. Results Higher use of avoidance coping at T1 was related to greater severity in sleep-related symptoms (p<0.01) and more interference with daily functioning (p<0.001) at T2. Approach coping at T1 was unrelated to indicators of sleep quality. Depressive symptoms and not intrusive thoughts mediated the relationship between avoidance coping and sleep symptom interference and partially mediated the effect on sleep symptom severity based on examination of bootstrapped standard errors for indirect paths. Conclusions Avoidance of cancer-related stressors and circumstances likely contributes to declines in mood states and in turn compromises sleep. An individual's coping style may be an important consideration in the assessment and treatment of sleep problems in men with cancer.

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Sleep/Wake Patterns of Individuals With Advanced Cancer Measured by Ambulatory Polysomnography

Abstract: Participants experienced severe difficulty with "state maintenance", or the ability to maintain both the sleep and waking states. Research designed to identify the etiology of these problems is needed to develop effective interventions.

Cited by 103 publications

References 49 publications

Association between PER3 length polymorphism and onco-hematological diseases and its influences on fatigue on awakening in patients

Association between PER3 length polymorphism and onco-hematological diseases and its influences on fatigue on awakening in patients

Subjective sleep and overall survival in chemotherapy-naïve patients with metastatic colorectal cancer

Coping Style and Sleep Quality in Men with Cancer

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