This paper aims to present a comprehensive survey on information integration (II) in space informatics. With an ever-increasing scale and dynamics of complex space systems, II has become essential in dealing with the complexity, changes, dynamics, and uncertainties of space systems. The applications of space II (SII) require addressing some distinctive functional requirements (FRs) of heterogeneity, networking, communication, security, latency, and resilience; while limited works are available to examine recent advances of SII thoroughly. This survey helps to gain the understanding of the state of the art of SII in sense that (1) technical drivers for SII are discussed and classified; (2) existing works in space system development are analyzed in terms of their contributions to space economy, divisions, activities, and missions; (3) enabling space information technologies are explored at aspects of sensing, communication, networking, data analysis, and system integration; (4) the importance of first-time right (FTR) for implementation of a space system is emphasized, the limitations of digital twin (DT-I) as technological enablers are discussed, and a concept digital-triad (DT-II) is introduced as an information platform to overcome these limitations with a list of fundamental design principles; (5) the research challenges and opportunities are discussed to promote SII and advance space informatics in future.INDEX TERMS Information integration (II), space informatics, digital triad (DT-II), internet of digital-triad things (IoDTT), first-time right (FTR), space information integration (SII). FIGURE 2. Technical drivers of II applications.