A wide-ranging review is presented on the most focal aspects of gas-liquid-solid reactors to discuss the fresh headways towards the understanding of slurry bubble column reactors' behavior. In more detail, in this critical review, published works' findings concerning the effects of solid particles characteristics (size, concentration and density) on volumetric mass transfer coefficient, liquid-side mass transfer coefficient, gas-liquid interfacial area, gas hold-up and flow regime are deliberated. Besides, the effects of other pivotal parameters such as pressure, temperature, reactor size, height of liquid, gas distributor, density, and viscosity on the performance of slurry bubble column reactors are considered. Eventually, regarding the effects of each of the aforementioned parameters on the performance of reactor, logical conclusions are drawn.