Small cell osteosarcoma of a toe phalanx: a case report and review of literature

PosthumaDeBoer, Jantine; Graat, Harm C.A.; Bras, Johannes; Saouti, Rachid

doi:10.1186/1749-799x-5-36

Cited by 8 publications

(4 citation statements)

References 19 publications

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“…The reference lists of the included studies were screened for additional potentially eligible articles. In total, 58 manuscripts with 336 cases were identified [6] , [7] , [8] , [9] , [11] , [12] , [13] , [14] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] . Follow-up information was available for 140 patients ( Fig.…”

Section: Methodsmentioning

confidence: 99%

Clarifying prognostic factors of small cell osteosarcoma: A pooled analysis of 20 cases and the literature

Zhong

et al. 2020

Journal of Bone Oncology

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Introduction Small cell osteosarcoma (SCOS) is a rare subtype of osteosarcoma, with limited studies mainly focusing on histological features. Our study aims to analyze our own patients and those reported in the literature to increase the recognition of this rare disease, to evaluate patient survival and to further determine potential prognostic factors. Material and methods Twenty patients with SCOS were treated in our hospital between 2010 and 2019. Their follow-up data were collected retrospectively. A total of 336 literature cases from 58 manuscripts were retrieved by means of a PubMed search with the key word “small cell osteosarcoma”. Data pertaining to treatment and follow-up were extracted. We performed a pooled analysis for the survival of patients and the risk factors for local recurrence (LR), as well as metastatic disease (MD), in a total of 160 patients using the Kaplan-Meier method and Cox regression method. Results We reported our experience in diagnosing and treating SCOS. In our cases, elevated alkaline phosphatase (P = 0.013) and lactate dehydrogenase (P = 0.001) significantly impaired overall survival. In the pooled analysis, SCOS was diagnosed at the median age of 17 years and affected both sexes almost equally. The median follow-up duration was 19.5 months. In the pooled analysis cases, the 5-year overall survival rate was 38.6%, and 36.4% of patients survived 10 years. However, an increasing trend was detected, indicating recent improvements in management. The surgical margin status (P = 0.024) and metastases (P = 0.008) significantly impaired overall survival, and the response to chemotherapy was related to disease-free survival (P = 0.012). LR and MD were significantly correlated (P = 0.002) and could be observed after 5 years of follow-up. LR was significantly dependent on response to chemotherapy (P = 0.020). The development of MD seemed to be affected by response to chemotherapy (P = 0.060). Correlations between imaging features and prognosis were not detected. Conclusions This study suggested that positive margins, poor response to chemotherapy and MD are negative prognostic factors for SCOS, implied the potential role of laboratory examinations in the survival prediction and supported the need for prolonged or more intensive surveillance in patients with MD or LR. More well-documented literatures are encouraged to allow further confirmations.

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Section: Methodsmentioning

confidence: 99%

Clarifying prognostic factors of small cell osteosarcoma: A pooled analysis of 20 cases and the literature

Zhong

et al. 2020

Journal of Bone Oncology

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“…Osteosarcoma is the most common primary malignant bone tumor in children and adolescents, which derives from primitive bone-forming mesenchymal cells 1 . The main clinical symptoms of osteosarcoma are pain, swelling, redness, and dysfunction of bone in localized areas 2,3 . With the development of multiple therapeutic strategies, such as wide tumor resection, adjuvant chemotherapy, and radiotherapy, the 5-year survival rate of nonmetastatic patients has increased from 20% to 70% 4 .…”

Section: Introductionmentioning

confidence: 99%

Knockdown of Long Noncoding RNA CAT104 Inhibits the Proliferation, Migration, and Invasion of Human Osteosarcoma Cells by Regulating MicroRNA-381

Xia

Wang

et al. 2018

oncol res

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Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. This study aimed to explore the effects of long non-coding RNA CAT104 and microRNA-381 (miR-381) on osteosarcoma cell proliferation, migration, invasion and apoptosis, as well as the underlying potential mechanism. We found that CAT104 was highly expressed in osteosarcoma MG-63 and OS-732 cells. Knockdown of CAT104 significantly inhibited OS-732 cell proliferation, migration and invasion, but promoted cell apoptosis. CAT104 regulated the expression of miR-381 and miR-381 participated in the effects of CAT104 on OS-732 cells. Zinc finger E box binding homeobox 1 (ZEB1) was a direct target gene of miR-381, which was involved in the regulatory roles of miR381 in OS-732 cell proliferation, migration, invasion and apoptosis, as well as c-Jun Nterminal kinase (JNK) and Wnt/ß-catenin pathways. In conclusion, our research verified that suppression of CAT104 exerted significant inhibitory effects on osteosarcoma cell proliferation, migration and invasion by regulating the expression of miR-381 and downstream ZEB1, as well as JNK and Wnt/ß-catenin pathways.

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“…Bone tumours are a varied group of malignant and benign tumours. Worldwide, osteosarcoma is the most common primary malignant bone tumour in children and adolescents (Meyers and Gorlick, 1997;Damron et al, 2007;PosthumaDeBoer et al, 2010), with a peak incidence at age 15-19 years old (Pruksakorn et al, 2016), accounting for 30-80% of all primary sarcomas (Evola et al, 2017). Ewing's sarcoma is the second most common primary malignant bone tumour in children (Grimer et al, 2010), with a peak incidence in the 0-9 years olds (Arora et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Modelling count data with an excess of zero values applied to childhood bone tumour incidence in Iraq

Al-Hashimi

Warttan

2021

Geospat Health

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Bone tumours are rarely found in children and adolescents (0- 19 years old), but there are reports from some provinces in Iraq indicating possible increases in the incidence of childhood bone cancer. Since counts are very low and often zero, or near zero, we fitted zero-inflated Poisson, zero-inflated negative binomial, Poisson hurdle, and negative binomial hurdle regression models to investigate these changes. We used data covering the 2000-2015 period taking age, gender and province into account with the aim of identifying potential health disparities. The results indicate that the zero-inflated Poisson is the most appropriate approach. We also found that, the incidence rate ratio of bone tumours for age groups of 5-9, 10-14 and 15-19 years were 134%, 490% and 723% higher, respectively, compared to the 0-4 year olds. The incidence rate was higher by 49% higher in males compared to females. Compared to 2000-2004, the rate was higher during 2005-2009 and 2010-2015 by 23% and 50%, respectively. In addition, the provinces Al-Muthana and Al-Diwaniyah in the South were found to have a higher incidence rate than other provinces. Join point analysis showed that the age-adjusted incidence rate had a significant, increasing trend, with an average percentage change of 3.1% during 2000-2015. The study suggests that further research into childhood tumours, bone tumours in particular, is needed. Reference to the effect of environmental factors in this group of medical disorders would be of special interest.

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Small cell osteosarcoma of a toe phalanx: a case report and review of literature

Cited by 8 publications

References 19 publications

Clarifying prognostic factors of small cell osteosarcoma: A pooled analysis of 20 cases and the literature

Clarifying prognostic factors of small cell osteosarcoma: A pooled analysis of 20 cases and the literature

Knockdown of Long Noncoding RNA CAT104 Inhibits the Proliferation, Migration, and Invasion of Human Osteosarcoma Cells by Regulating MicroRNA-381

Modelling count data with an excess of zero values applied to childhood bone tumour incidence in Iraq

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