Small Nucleolar RNAs: Insight Into Their Function in Cancer

Liang, Jintai; Wen, Jingyuan; Hu, Zhao; Chen, Xiaoping; Zhang, Bixiang; Chu, Liang

doi:10.3389/fonc.2019.00587

Cited by 213 publications

(218 citation statements)

References 94 publications

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“…Finally, the SNORD76, a box C/D snoRNA has been shown to act as a tumor suppressor in glioblastoma [62], a similar effect observed with the depletion of jouvence in U87-MG glioblastoma cell line. In conclusion, as previously suggested [10,11], snoRNAs have the potential to become cancer biomarkers, and even may potentially become major cancer therapeutic targets in the near future. In such way, the snoRNA-jouvence is surely another good and promising candidate.…”

Section: Discussionsupporting

confidence: 59%

“…Several snoRNAs (both C/D and H/ACA boxes) have also been involved in many biological cancer processes, as tumor initiation, invasion, metastasis, and/or proliferative signalling [10,11]. For examples, some snoRNAs have been associated with the p53 pathway, a well-known tumor suppressor [54].…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, several snoRNAs have been reported to participate in many biological cancer processes, as inactivation of growth suppressors and cell death, activation of invasion and metastasis, as well as sustained proliferative signalling [11]. Moreover, some evidences suggest that snoRNA could also play a role in cancer stem cells (CSC), as these last have the capacities of selfrenewal, differentiation and tumorigenicity [12].…”

Section: Introductionmentioning

confidence: 99%

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jouvence, a new human H/ACA snoRNA involves in the control of cell proliferation and differentiation

El-Khoury

Bignon

Martin

2020

Preprint

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Small nucleolar RNAs (snoRNAs) are non-coding RNAs conserved from archeobacteria to mammals. In humans, various snoRNAs have been associated with pathologies as well as with cancer. Recently in Drosophila, a new snoRNA named jouvence has been involved in lifespan.Since snoRNAs are well conserved through evolution, both structurally and functionally, jouvence orthologue has been identified in human, allowing hypothesizing that jouvence could display a similar function (increasing healthy lifespan) in human. Here, we report the characterization of the human snoRNA-jouvence, which was not yet annotated in the genome.We show, both in stably cancerous cell lines and in primary cells, that its overexpression stimulates the cell proliferation. In contrast, its knockdown, by siRNA leads to an opposite phenotype, a decrease in cell proliferation. Transcriptomic analysis reveals that overexpression of jouvence leads to a dedifferentiation signature of the cells, a cellular effect comparable to rejuvenation. Inversely, the knockdown of jouvence leads to a decrease of genes involved in ribosomes biogenesis and spliceosome in agreement with the canonical role of a H/ACA box snoRNA. In this context, jouvence could represent a now tool to fight against the deleterious effect of aging, as well as a new target in cancer therapy.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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jouvence, a new human H/ACA snoRNA involves in the control of cell proliferation and differentiation

El-Khoury

Bignon

Martin

2020

Preprint

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“…The most represented group of genes in the set of highly changed ones are those encoding small nucleolar RNAs (snoRNAa), which are responsible for methylation (class C/D) or pseudouridylation (class H/ACA) of ribosomal RNA [45]. They play an important role in maturation of rRNA and regulate mRNA splicing and editing, but there is also evidence of their involvement in other processes and cellular pathways, including those related to p53 tumor suppressor or phosphoinositide 3-kinase [46].…”

Section: Gene Microarray Analysismentioning

confidence: 99%

Local and Systemic Humoral Response to Autologous Lineage-Negative Cells Intrathecal Administration in ALS Patients

Baumert

Sobuś

Gołąb-Janowska

et al. 2020

IJMS

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Amyotrophic lateral sclerosis (ALS) remains a fatal disease with limited therapeutic options. Signaling via neurotrophins (NTs), neuroinflammation, and certain micro-RNAs are believed to play essential role in ALS pathogenesis. Lineage-negative stem/progenitor cells (Lin−) were obtained from bone marrow of 18 ALS patients and administered intrathecally. Clinical assessment was performed using ALS Functional Rating Scale (FRSr) and Norris scale. Protein concentrations were measured in plasma and cerebrospinal fluid (CSF) by multiplex fluorescent bead-based immunoassay. Gene expression in nucleated blood cells was assessed using gene microarray technique. Finally, miRNA expression was analyzed using qPCR in CSF and plasma samples. We observed a significant decrease of C-reactive protein (CRP) concentration in plasma on the seventh day from the application of cells. Gene array results revealed decreased expression of gene sets responsible for neutrophil activation. Further analysis revealed moderate negative correlation between CRP level in CSF and clinical outcome. Brain-derived neurotrophic factor (BDNF) concentrations in both plasma and CSF significantly correlated with the favorable clinical outcome. On a micro-RNA level, we observed significant increase of miR-16-5p expression one week after transplantation in both body fluids and significant increase of miR-206 expression in plasma. Administration of Lin− cells may decrease inflammatory response and prevent neurodegeneration. However, these issues require further investigations.

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“…Cui et al 151 found that tDR‐0009 and tDR‐7336 were notably upregulated in the SUM‐1315 cell lines stimulated by hypoxia; further, bioinformatic analysis indicated that these two upregulated tDRs might be involved in the chemoresistance to doxorubicin in TNBC via mediating the activation of phosphorylation of STAT3. As for other ncRNAs, such as snoRNA and snRNA, their tumour‐associated functions have been observed in multiple cancers, 152‐154 but no exact roles have been defined in TNBC, which need to be further explored in the future.…”

Section: Other Non‐coding Rnasmentioning

confidence: 99%

Systematic characterization of non‐coding RNAs in triple‐negative breast cancer

et al. 2020

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Triple‐negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer with negativity for oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor (HER2). Non‐coding RNAs (ncRNAs) make up most of the transcriptome and are widely present in eukaryotic cells. In recent years, emerging evidence suggests that ncRNAs, mainly microRNAs (miRNAs), long ncRNAs (lncRNAs) and circular RNAs (circRNAs), play prominent roles in the tumorigenesis and development of TNBC, but the functions of most ncRNAs have not been fully described. In this review, we systematically elucidate the general characteristics and biogenesis of miRNAs, lncRNAs and circRNAs, discuss the emerging functions of these ncRNAs in TNBC and present future perspectives in clinical practice.

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Small Nucleolar RNAs: Insight Into Their Function in Cancer

Cited by 213 publications

References 94 publications

jouvence, a new human H/ACA snoRNA involves in the control of cell proliferation and differentiation

jouvence, a new human H/ACA snoRNA involves in the control of cell proliferation and differentiation

Local and Systemic Humoral Response to Autologous Lineage-Negative Cells Intrathecal Administration in ALS Patients

Systematic characterization of non‐coding RNAs in triple‐negative breast cancer

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