Small-ring heterocycles as components of multidentate ligands: some structural studies relating to ring opening

Palladium and platinum 2,4-cis-amino azetidine and related complexes

“…In our research, through studying the synthesis and cyclisation of homoallylamine derivatives Rixe et al, 1996;Jamieson and Lippard, 1999;Feula et al, 2010Feula and Fossey, 2013;Hama Salih et al, 2015), the potential for use of the cis-aminoazetidine products as ligands emerged, and their use in asymmetric copper-catalyzed Henry reactions was developed and reported elsewhere (Yoshizawa et al, 2018a,b,c). Group 10 complexes of azetidine derivatives have been reported previously (Voureka et al, 1996;Keller et al, 2005;Lee et al, 2008Lee et al, , 2009aChoi et al, 2011), and during our aforementioned studies various attempts to form and isolate racemic group 10 metal complexes have been made. Successful attempts to prepare crystals of metal complexes suitable for single crystal X-ray diffraction structure determination are reported herein, along with crystal structures of unexpected by-products, a complex formed from a pyrrolidine ligand (an isomer of the azetidines of primary interest) as well as an observation pertaining to diastereoisomer differentiation upon complexation and sample preparation under slightly different conditions.…”