Smell with new neurons

Yuan, Ti‐Fei

doi:10.1007/s00441-010-0964-x

Cited by 10 publications

(5 citation statements)

References 37 publications

(45 reference statements)

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“…The new neurons generated in hippocampus is important for learning and memory [1], as well as emotion state regulation [5,31], while the ventricular zone-generated new neurons migrate into a range of brain regions including olfactory bulb, hypothalamus, amygdala and piriform cortex, contributing to olfaction [14,40,43], defending the virus infection [16], and metabolism regulation [41]. Adult neurogenesis is also proposed as an important mechanism to repair the brain after injury or to maintain the brain plasticity in different circumstances [2,16,42].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Adult Neurogenesis

Yuan

Shan

et al. 2015

Stem Cell Rev and Rep

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There is a growing evidence that adult neurogenesis is critical for brain function. The reactive oxygen species (ROS) is accumulated during adult neurogenesis as a physiological mechanism; while ROS overload impairs adult neurogenesis during ageing, neuroinflammation and neurodegeneration. Here we propose that targeting oxidative stress provides a novel way to regulate adult neurogenesis and manage different brain diseases.

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Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Adult Neurogenesis

Yuan

Shan

et al. 2015

Stem Cell Rev and Rep

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“…In the case of olfactory receptors, this means that specific odorant molecules differing in binding energy thresholds may combine synchronically and, together, represent the "odor-image" of a given umwelt, On higher hierarchical levels, cell-to-cell relationships are also explored through developmentally adaptable mechanisms and semiotic perceptual learning. It has been recently observed that olfaction is influenced by newly born neurons and that adult neurogenesis is conditioned by both training and/or environmental exposure (Yuan, 2010). This is a clear example illustrating how adult neurogenesis and olfactory perceptual learning are reciprocally dependent on each other.…”

Section: Biosemiotic Analysismentioning

confidence: 95%

Are Olfactory Receptors Really Olfactive?

2011

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Any living organism interacts with and responds specifically to environmental molecules by expressing specific olfactory receptors. In this paper, this specificity will be first examined in causal terms with particular emphasis on the mechanisms controlling olfactory gene expression, cell-to-cell interactions and odordecoding processes. However, this type of explanation does not entirely justify the role olfactory receptors have played during evolution, since they are also expressed ectopically in different organs and/or tissues. Homologous olfactory genes have in fact been found in such diverse cells and/or organs as spermatozoa, testis and kidney where they are assumed to act as chemotactic sensors or renin modulators. To justify their functional diversity, homologous olfactory receptors are assumed to share the same basic role: that of conferring a self-identity to cells or tissues under varying environmental conditions. By adopting this standpoint, the functional attribution as olfactory or chemotactic sensors to these receptors should not be seen either as a cause conditioning receptor gene expression, or as a final effect resulting from genetically predetermined programs, but as a direct consequence of the environmental conditions olfactory receptor genes have explored during evolution. The association of odorant patterns with specific environmental or contextual situations makes their relationship semiotically triadic, due to the emergence of an interpretant capable of perceiving odorants as meaningful signs out of a noisy background. This perspective highlights the importance of odorant-receptor relationships as respect to the properties of the interacting partners. It is our contention that only when taken together can these different explanatory strategies provide a realistic account of how olfactory receptor genes have been structurally and functionally modified during evolution.

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“…Jedną z niezwykłych cech systemu węchowego jest jego zdolność do regeneracji neuronów czuciowych nabłonka węchowego (olfactory epithelium -OE). Neurogeneza zachodzi zarówno w OE, jak i w opuszce węchowej (olfactory bulb -OB), a nowo powstałe neurony mogą migrować do obszarów peryferyjnych, stając się interneuronami, ziarnami (granule) i komórkami glomerularnymi (Yuan 2010). Szacuje się, że receptory węchu i smaku regenerują się co sześćdziesiąt dni (Doetsch i wsp.…”

Section: Introductionunclassified

Neuroanatomical and neurophysiological foundations of the human olfactory system

Mydlikowska-Śmigórska¹,

Śmigórski²

2016

nin

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Smell with new neurons

Cited by 10 publications

References 37 publications

Oxidative Stress and Adult Neurogenesis

Oxidative Stress and Adult Neurogenesis

Are Olfactory Receptors Really Olfactive?

Neuroanatomical and neurophysiological foundations of the human olfactory system

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