Smoking and adverse outcomes at radical prostatectomy

Association of Cigarette Smoking and Smoking Cessation with Biochemical Recurrence of Prostate Cancer in Patients Treated with Radical Prostatectomy

“…The mechanisms underlying the detrimental effect of cigarette smoking on PCa biology and prognosis remain largely unclear. In contrast to our results, other studies found that smokers had unfavorable clinicopathologic features at RP suggestive of clinically more aggressive disease in comparison to men who never smoked [8][9][10]13].…”

“…These results are comparable to previous studies. In an analysis of 630 men treated with RP, heavy smoking defined as 20 pack-years as a continuous variable was associated with higher risk of BCR [10]. However, while the multivariable model of this study included volume of cancer and volume of high-grade cancer, there was no adjustment for the effects of tumor stage, Gleason score, or margin and nodal status.…”

“…Ngo et al [10] reported a higher risk of BCR for patients with 20 packyears compared with 0-19 pack-years in a study of 630 patients treated with RP. Similarly, a recent metaanalysis of 12 studies on smoking and PCa mortality found that the number of cigarettes smoked at baseline was associated with PCa mortality [6].…”

“…In addition, the number of cigarettes smoked shows a dose-response association with PCa death [6]. However, studies on the association between smoking and risk of biochemical recurrence (BCR) in PCa patients treated with radical prostatectomy (RP) have yielded conflicting results [7][8][9][10]. In addition, previous studies did not investigate groups of former smokers [8][9][10], the effect of cumulative exposure [8,9], or the effect of time since smoking cessation on the risk of BCR [7][8][9][10].…”

Role of cigarette smoking in urological malignancies and clinical interventions for smoking cessation

“…In patients undergoing radical prostatectomy, smoking was associated with adverse pathologic features (greater volumes and high grade cancer) and a higher risk of biochemical recurrence in men undergoing radical prostatectomy [11, 12]. A similar scenario is evident for patients treated with radiotherapy or androgen deprivation therapy [13].…”