Smoking, Dopamine Transporter, and Hand Tremor

Lin, Chun-Yi; Yeh, Chung-Hsin; Chang, Tien-Tien; Kao, Chia-Hong; Tsai, Song-Yen

doi:10.1097/rlu.0b013e318238f12d

Cited by 4 publications

(5 citation statements)

References 28 publications

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“…There were seven studies assessing dopamine transporter availability in 123 smokers and 184 healthy controls (Cosgrove et al 2009b; Leroy et al 2012; Lin et al 2012; Newberg et al 2007; Staley et al 2001; Thomsen et al 2013; Yang et al 2008). The meta-analysis showed a significant reduction in dopamine transporter availability in the smoker relative to control groups with an effect size of − 0.72 ([95% CI, − 1.38 to − 0.05], p = 0.03) (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Tobacco smoking and dopaminergic function in humans: a meta-analysis of molecular imaging studies

2019

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Rationale About 1.1 billion people smoke tobacco globally and tobacco-related health care costs 1.8% of GDP in many countries. The majority of people are unable to quit smoking despite pharmacological intervention, highlighting the need to understand the pathophysiology associated with tobacco smoking to aid the development of new therapeutics. The reinforcing effects of tobacco smoking are thought to be mediated by the dopamine system. However, the nature of dopamine dysfunction seen in smokers is unclear. Objective To determine the nature and robustness of the evidence for dopaminergic alterations in smokers. Methods The entire MEDLINE, EMBASE, and PsycINFO databases were searched for studies from inception date to November 18, 2018. In vivo human molecular imaging studies of dopamine measures (dopamine synthesis or release capacity, transporter levels, receptor levels) in tobacco smokers were selected. Demographic, clinical, and imaging measures were extracted from each study and meta-analyses, and sensitivity analyses were conducted. Results Fourteen studies met inclusion criteria comprising a total sample of 219 tobacco smokers and 297 controls. The meta-analysis showed a significant reduction in dopamine transporter availability in the smokers relative to controls with an effect size of − 0.72 ([95% CI, − 1.38 to − 0.05], p = 0.03). However, there was no difference in D2/3 receptor availability in smokers relative to controls ( d = −0.16 ([95% CI, − 0.42 to 0.1], p = 0.23). There were insufficient studies for meta-analysis of other measures. However, findings from the published studies indicated blunted dopamine release and lower D1 receptor availability, while findings for dopamine synthesis capacity were inconsistent. Conclusion Our data indicate that striatal dopamine transporter availability is lower but D2/3 receptors are unaltered in smokers relative to controls. We discuss the putative mechanisms underlying this and their implications. Electronic supplementary material The online version of this article (10.1007/s00213-019-05196-1) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Tobacco smoking and dopaminergic function in humans: a meta-analysis of molecular imaging studies

2019

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“…Because tobacco use mediates the regulation of dopamine in areas responsible for movement 21,24 , we examined group differences by treating frequency of tobacco use as a covariate. As gender was significantly different between groups, male/female was also treated as a statistical covariate.…”

Section: Representative Resultsmentioning

confidence: 99%

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Dean

Teulings

Caligiuri

et al. 2013

JoVE

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Growing evidence suggests that movement abnormalities are a core feature of psychosis. One marker of movement abnormality, dyskinesia, is a result of impaired neuromodulation of dopamine in fronto-striatal pathways. The traditional methods for identifying movement abnormalities include observer-based reports and force stability gauges. The drawbacks of these methods are long training times for raters, experimenter bias, large site differences in instrumental apparatus, and suboptimal reliability. Taking these drawbacks into account has guided the development of better standardized and more efficient procedures to examine movement abnormalities through handwriting analysis software and tablet. Individuals at risk for psychosis showed significantly more dysfluent pen movements (a proximal measure for dyskinesia) in a handwriting task. Handwriting kinematics offers a great advance over previous methods of assessing dyskinesia, which could clearly be beneficial for understanding the etiology of psychosis.

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“…Health care utilization, 37,38 GAD, 39,40 and somatic symptoms [41][42][43][44][45][46][47] have earlier reported to be associated with smoking status, alcohol consumption, body mass index (BMI), occupational class, and somatic diseases. Therefore, these variables were taken into account as confounding variables.…”

Section: Methodsmentioning

confidence: 99%

The association of generalized anxiety disorder and Somatic Symptoms with frequent attendance to health care services

Kujanpää

Jokelainen

Auvinen

et al. 2017

Int J Psychiatry Med

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Objective Generalized anxiety disorder is associated with higher rate of physical comorbities, unexplained symptoms, and health care utilization. However, the role of somatic symptoms in determining health care utilization is unclear. The present study aims to assess the association of frequent attendance of health care services between generalized anxiety disorder symptoms and somatic symptoms. Method This study was conducted cross-sectionally using the material of the 46-year follow-up survey of the Northern Finland Birth Cohort 1966. Altogether, 5585 cohort members responded to the questionnaires concerning health care utilization, illness history, physical symptoms, and generalized anxiety disorder-7 screening tool. Odds ratios belonging to the highest decile in health care utilization were calculated for generalized anxiety disorder symptoms and all (n = 4) somatic symptoms of Hopkins Symptom Checklist-25 controlled for confounding factors. Results Adjusted Odds ratios for being frequent attender of health care services were 2.29 (95% CI 1.58-3.31) for generalized anxiety disorder symptoms and 1.28 (95% CI 0.99-1.64), 1.94 (95% CI 1.46-2.58), 2.33 (95% CI 1.65-3.28), and 3.64 (95% CI 2.15-6.18) for 1, 2, 3, and 4 somatic symptoms, respectively. People with generalized anxiety disorder symptoms had on average a higher number of somatic symptoms (1.8) than other cohort members (0.9). Moreover, 1.6% of people without somatic symptoms tested positive for generalized anxiety disorder, meanwhile 22.6% of people with four somatic symptoms tested positive for generalized anxiety disorder. Conclusions Both generalized anxiety disorder symptoms and somatic symptoms are associated with a higher risk for being a health care frequent attender.

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Smoking, Dopamine Transporter, and Hand Tremor

Cited by 4 publications

References 28 publications

Tobacco smoking and dopaminergic function in humans: a meta-analysis of molecular imaging studies

Tobacco smoking and dopaminergic function in humans: a meta-analysis of molecular imaging studies

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

The association of generalized anxiety disorder and Somatic Symptoms with frequent attendance to health care services

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Smoking, Dopamine Transporter, and Hand Tremor

Cited by 4 publications

References 28 publications

Tobacco smoking and dopaminergic function in humans: a meta-analysis of molecular imaging studies

Tobacco smoking and dopaminergic function in humans: a meta-analysis of molecular imaging studies

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Na&#239;ve Adolescents at High Risk for Psychosis

The association of generalized anxiety disorder and Somatic Symptoms with frequent attendance to health care services

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Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis