Smoking Is Independently Associated With High Plasma Insulin Levels in Nondiabetic Men

Rönnemaa, Tapani; Rönnemaa, Elina; Puukka, Pauli; Pyörälà, Kalevi; Laakso, Markku

doi:10.2337/diacare.19.11.1229

Cited by 148 publications

(106 citation statements)

References 6 publications

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“…Many studies have shown that smoking is associated with insulin resistance [10][11][12]. However, studies on the relationship between smoking cessation period and insulin resistance are rare.…”

Section: Discussionmentioning

confidence: 99%

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Association between the time of length since smoking cessation and insulin resistance in asymptomatic Korean male ex-smokers

Kim¹

2017

J Gen Pract (Los Angel)

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Aim. Smoking is a major risk factor for diabetes mellitus, mainly due to decreased insulin secretion and increased insulin resistance. However, there has been little research on the effects of smoking cessation period on changes in insulin resistance. In this study, we investigated the relationships between the length of time since smoking cessation period and insulin resistance in asymptomatic Korean male ex-smokers. Methods. A total of 851 male adults were included in this study. We considered several factors that can affect insulin resistance, and through multiple linear regression analysis, we assessed the effect the length of time since smoking cessation on insulin resistance in ex-smokers. Insulin resistance was represented as the insulin resistance index estimated by homeostasis model assessment. Results. HOMA-IR values showed a statistically significant negative correlation with the length of time since smoking cessation (p = 0 009) in ex-smokers. After performing multiple linear regression analysis using factors that could potentially influence insulin resistance, we found that waist circumference (p = 0 026) and the length of time since smoking cessation (p = 0 039) were independent predictors of HOMA-IR in asymptomatic male ex-smokers. Conclusion. The longer the smoking cessation period, the more the insulin resistance tended to decrease in asymptomatic Korean male ex-smokers.

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Section: Discussionmentioning

confidence: 99%

“…Smoking is also a major risk factor for diabetes because it decreases insulin secretion [9] and increases insulin resistance [10][11][12]. Many studies have shown that active smoking increases the prevalence and incidence of not only type 2 diabetes mellitus (DM) [13][14][15] but also glucose intolerance [16].…”

Section: Introductionmentioning

confidence: 99%

Association between the time of length since smoking cessation and insulin resistance in asymptomatic Korean male ex-smokers

Kim¹

2017

J Gen Pract (Los Angel)

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“…The association was independent of fasting glucose and other covariates related to gallbladder disease. Prior studies that found an association of gallbladder disease and insulin levels had smaller sample sizes and did not control for the large number of covariates that could potentially confound the relationship, such as race-ethnicity, 26 obesity, 27 regional fat distribution, 28 exogenous estrogen, 29 smoking, 30 and physical activity. 31 The association of gallblad- *From binary linear regression analysis adjusted for age, race-ethnicity, BMI, waist-to-hip ratio, serum total cholesterol level, and alcohol consumption.…”

Section: Discussionmentioning

confidence: 99%

Association of diabetes, serum insulin, and c-peptide with gallbladder disease

2000

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An inconsistent association has been found between gallbladder disease and diabetes mellitus. We hypothesized that insulin resistance rather than diabetes status may be a primary factor involved in gallstone formation. A total of 5,653 adult participants in the third United States National Health and Nutrition Examination Survey without known diabetes underwent gallbladder ultrasonography and phlebotomy after an overnight fast for measurement of serum insulin, C-peptide, and glucose. Gallbladder disease was defined as ultrasound-documented gallstones or evidence of cholecystectomy. Subjects were characterized as having normal fasting glucose (F110 mg/dL), impaired fasting glucose (110 to F126 mg/dL), or undiagnosed diabetes (H126 mg/dL). After controlling for other known gallbladder disease risk factors, among women, undiagnosed diabetes was associated with increased risk of gallbladder disease (prevalence ratio [PR] ‫؍‬ 1.91, 95% confidence interval [CI] ‫؍‬ 1.29-2.83); whereas impaired fasting glucose was unassociated. Gallbladder disease risk in women increased with levels of fasting insulin (PR ‫؍‬ 1.63, 95% CI ‫؍‬ 1.11-2.40) and C-peptide (PR ‫؍‬ 2.07, 95% CI ‫؍‬ 1.32-3.25) comparing highest to lowest quintiles. However, the association of gallbladder disease with undiagnosed diabetes was not diminished when the model included fasting insulin (PR ‫؍‬ 1.85, 95% CI ‫؍‬ 1.24-2.77). In men, there was a statistically nonsignificant association with undiagnosed diabetes (PR ‫؍‬ 2.11, 95% CI ‫؍‬ 0.76-5.85), but no association of gallbladder disease with insulin or C-peptide. Among women higher fasting serum insulin levels increased the risk of gallbladder disease, but did not account for the increased risk in persons with diabetes. (HEPATOLOGY 2000;31:299-303.)

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“…Previous studies have shown that smoking reduces insulin sensitivity or induces insulin resistance [10][11][12][13][14][15] Chiang PH et al . Smoking, fatty liver and metabolic syndrome 5335 www.wjgnet.com and enhances cardiovascular risk factors such as elevated plasma triglycerides (TG) [16][17][18][19] , decreased high-density lipoprotein cholesterol (HDL-C) [16,20] and hyperglycemia [11] .…”

Section: Introductionmentioning

confidence: 99%

Synergistic effect of fatty liver and smoking on metabolicsyndrome

Chiang¹,

Chang²,

Chen³

2009

WJG

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AIM:To investigate the association of fatty liver and smoking on metabolic syndrome and its components. METHODS:This cross-sectional study enrolled participants who attended annual health screening at Shin Kong Wu Ho-Su Memorial Hospital from January to December 2005. A total of 3455 (1981 men and 1474 women) subjects were included in final analyses. Fatty liver was diagnosed using abdominal ultrasonography by trained gastroenterologists. The modified National Cholesterol Education Program Adult Treatment Panel Ⅲ was used to define metabolic syndrome. The associations between smoking, fatty liver and metabolic syndrome were analyzed using multiple logistic regression. RESULTS:Subjects with fatty liver, and who smoked tobacco, had the highest odds ratios (ORs) for high waist circumference [OR, 4.5 (95% CI: 3.3-6.1), P < 0.05], hypertriglyceridemia [OR, 8.1 (95% CI: 6.0-10.9), P < 0.05], low serum high-density lipoprotein cholesterol (HDL-C) [OR, 8.3 (95% CI: 6.1-11.3), P < 0.05], and metabolic syndrome [OR, 9.5 (95% CI: 6.7-13.4), P < 0.05] compared to subjects without fatty liver who did not smoke tobacco. We also found that the ORs for hypertriglyceridemia, low serum HDL-C, and metabolic syndrome for subjects with fatty liver who smoked tobacco had greater than the sum of the ORs for subjects with fatty liver who did not smoke plus those who did not have fatty liver and who did smoke.CONCLUSION: Fatty liver and smoking had a synergistic effect on metabolic syndrome and its components, especially for hypertriglyceridemia and low serum HDL-C.

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Smoking Is Independently Associated With High Plasma Insulin Levels in Nondiabetic Men

Abstract: Our results show that chronic smoking is associated with high age- and BMI-adjusted plasma insulin levels, independent of other factors known to influence insulin sensitivity. The effect of smoking may be partially reversible after quitting.

Cited by 148 publications

References 6 publications

Association between the time of length since smoking cessation and insulin resistance in asymptomatic Korean male ex-smokers

Association between the time of length since smoking cessation and insulin resistance in asymptomatic Korean male ex-smokers

Association of diabetes, serum insulin, and c-peptide with gallbladder disease

Synergistic effect of fatty liver and smoking on metabolicsyndrome

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