SO‐CALLED “PAPILLARY and CYSTIC NEOPLASM OF THE PANCREAS”

Kamisawa, Terumi; Fukayama, Masashi; Koike, Masato; Tabata, I; Okamoto, Akira

doi:10.1111/j.1440-1827.1987.tb00412.x

Cited by 16 publications

(3 citation statements)

References 31 publications

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“…Although the pathologic features of SPT have been well described in recent years, its phenotype could not be clearly related to any of the wellcharacterized cells of the pancreas. Some studies indicated an origin from acinar cells [2,18,21,22,23] or endocrine cells [16,43,46], but the results of most other studies have not been compatible with these suggestions [19,28,36]. The immunocytochemical phenotype is characterized by the frequent expression of vimentin, neuron-specific enolase (NSE), and alpha-1-antitrypsin (AAT) [41].…”

Section: Introductionmentioning

confidence: 99%

Solid-pseudopapillary tumor of the pancreas: its origin revisited

Kosmahl¹,

et al. 2000

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Solid-pseudopapillary tumor of the pancreas (SPT) has distinctive morphologic and biologic features but an unclear origin. It is classified among the pancreatic epithelial tumors, though many are reported to be negative for cytokeratin. Also unclear are its neuroendocrine differentiation, its capability to express alpha-1-antitrypsin (AAT) and, in view of the tumor's striking prevalence in women, its relationship with the female genital tract. To clarify these issues, the immunoprofiles of 59 SPTs were defined by applying a battery of antibodies against cytokeratin, vimentin, neuron-specific enolase (NSE), synaptophysin, chromogranin A, tyrosine hydroxylase (TH), AAT, LeuM1, Ki-M1P, smooth-muscle actin, CD34, alpha-inhibin, calretinin, placental alkaline phosphatase (PLAP), and progesterone and estrogen receptors. The most consistent markers with the strongest immunoreactivity were vimentin, AAT, NSE, and the progesterone receptor, which were each found in more than 90% of the tumors. Using immunocytochemical methods involving antigen retrieval, cytokeratin was demonstrated in almost 70% of the cases. Synaptophysin was found in 22% of the tumors, while chromogranin was absent and tyrosine hydroxylase was only present in a few tumors. None of the other markers tested were expressed by SPTs. This staining pattern fails to reveal a clear phenotypic relationship with any of the defined cell lineages of the pancreas. In view of the striking female preponderance of SPTs and the known close approximation of the genital ridges to the pancreatic anlage during embryogenesis, it is, however, hypothesized that SPTs might derive from genital ridge/ovarian anlage-related cells, which were attached to the pancreatic tissue during early embryogenesis.

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Section: Introductionmentioning

confidence: 99%

Solid-pseudopapillary tumor of the pancreas: its origin revisited

Kosmahl¹,

et al. 2000

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“…До сих пор не вполне ясно, является ли кистозный вариант НЭО ПЖ первичной нейроэндокринной опухолью или результатом вторичных изменений. В мировой литературе представлены несколько предположений, так, по мнению Kamisawa et al, в медленно растущих НЭО развивается фиброзная капсула, которая ограничивает кровоснабжение и приводит к инфаркту, некрозу и, в конечном итоге, образует кистозный компонент [14]. Iacono et al и Takeshita et al высказывают мнение о внутреннем кровоизлиянии в сосудистой опухоли, в результате чего образуется крупная киста [15,16].…”

Section: Discussionunclassified

Rare Manifestation of Neuroendocrine Pancreatic Tumor: Difficulties of Diagnosis

Belozerskikh,

Kolobanova,

Lukianchenko

et al. 2023

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“…2 Kamisawa et al proposed that PanNETs are slow-growing tumors and in course of time they develop a fibrous capsule, hampering the blood supply to the tumor, resulting in infarction and necrosis leading to a cystic appearance. 3 Iacono et al suggested that hemorrhage is the initial event in the development of the tumor's cystic form. 4 Cystic PanNETs are more commonly located in the neck, body, or tail of the pancreas than in the head or uncinate process compared with the solid counterparts.…”

Section: Discussionmentioning

confidence: 99%

Cystic Pancreatic Neuroendocrine Tumor: A Diagnostic Dilemma

et al. 2022

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Pancreatic neuroendocrine tumors are typically solid neoplasms but in rare instances may present as cystic lesions. Preoperative diagnosis of a cystic pancreatic lesion is challenging and requires a multidisciplinary and multimodal approach. We hereby describe an elderly female who came with complaints of abdominal lump. Radiologically, it appeared to be a pancreatic hydatid cyst located at the head of the pancreas, following which resection was done. Histopathological study of the lesion turned out to be a cystic pancreatic neuroendocrine tumor. Thus, we present this unique case due to its rarity and diagnostic challenge.

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SO‐CALLED “PAPILLARY and CYSTIC NEOPLASM OF THE PANCREAS”

Cited by 16 publications

References 31 publications

Solid-pseudopapillary tumor of the pancreas: its origin revisited

Solid-pseudopapillary tumor of the pancreas: its origin revisited

Rare Manifestation of Neuroendocrine Pancreatic Tumor: Difficulties of Diagnosis

Cystic Pancreatic Neuroendocrine Tumor: A Diagnostic Dilemma

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