Social dominance in male vasopressin 1b receptor knockout mice

Caldwell, Heather K.; Dike, Obianuju E.; Stevenson, Erica L.; Storck, Kathryn; Young, W. Scott

doi:10.1016/j.yhbeh.2010.03.008

Cited by 34 publications

(29 citation statements)

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“…Variants within AVPR1B have been linked to social behavior in humans and other mammals. As mentioned earlier, Avpr1b −/− mice show decreased aggression and altered dominance behavior (Caldwell et al, 2010; Pagani et al, 2015). Human studies including our results have linked AVPR1B to disorders with social components including bipolar type I, depression, autistic traits as measured by EQ, childhood aggression, COMD, suicidal attempts, prosociality, and emotional empathy (Dempster et al, 2007; Chakrabarti et al, 2009; Leszczynska-Rodziewicz et al, 2012; Zai et al, 2012; Szczepankiewicz et al, 2013; Luppino et al, 2014; Wu et al, 2015).…”

Section: Discussionsupporting

confidence: 53%

“…Studies have shown that Avpr1b knockout mice display decreased ultrasonic vocalization in social situations throughout their lifespans, decreased aggression, and altered social behavior affiliated with dominance (Scattoni et al, 2008; Caldwell et al, 2010; Pagani et al, 2015). The relationship between Avpr1b and aggression was strengthened by the Pagani et al (2015) study, which showed the rescue of aggression by targeted expression of Avpr1b in the hippocampus.…”

Section: Introductionmentioning

confidence: 99%

“…The relationship between Avpr1b and aggression was strengthened by the Pagani et al (2015) study, which showed the rescue of aggression by targeted expression of Avpr1b in the hippocampus. Additionally, Caldwell et al (2010) observed increased aggression in Avpr1b −/− mice under specific social conditions including competition, food deprivation, and social experience. In humans, SNPs in AVPR1B have been linked to child aggression, childhood-onset mood disorders (COMD), prosociality, and autistic traits (Dempster et al, 2007, 2009; Chakrabarti et al, 2009; Zai et al, 2012; Wu et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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ASD and Genetic Associations with Receptors for Oxytocin and Vasopressin—AVPR1A, AVPR1B, and OXTR

et al. 2016

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Background: There are limited treatments available for autism spectrum disorder (ASD). Studies have reported significant associations between the receptor genes of oxytocin (OT) and vasopressin (AVP) and ASD diagnosis, as well as ASD-related phenotypes. Researchers have also found the manipulation of these systems affects social and repetitive behaviors, core characteristics of ASD. Consequently, research involving the oxytocin/vasopressin pathways as intervention targets has increased. Therefore, further examination into the relationship between these neuropeptides and ASD was undertaken. In this study, we examined associations between variants in the receptor genes of vasopressin (AVPR1A, AVPR1B), oxytocin (OXTR), and ASD diagnosis along with related subphenotypes.Methods: Probands were assessed using Autism Diagnostic Interview-Revised, Autism Diagnostic Observation Schedule, and clinical DSM-IV-TR criteria. Single nucleotide polymorphisms (SNPs) in AVPR1B and OXTR, and microsatellites in AVPR1A were genotyped in ~200 families with a proband with ASD. Family-based association testing (FBAT) was utilized to determine associations between variants and ASD. Haplotypes composed of OXTR SNPs (i.e., rs53576-rs2254298-rs2268493) were also analyzed due to previously published associations.Results: Using the additive inheritance model in FBAT we found associations between AVPR1B SNPs (rs28632197, p = 0.005, rs35369693, p = 0.025) and diagnosis. As in other studies, OXTR rs2268493 (p = 0.050) was associated with diagnosis. rs2268493 was also associated with ASD subphenotypes of social withdrawal (p = 0.013) and Insistence on Sameness (p = 0.039). Further analyses demonstrated that the haplotype, rs2254298–rs2268493 was found to be significantly associated with diagnosis (A-T; p = 0.026). FBAT was also used to analyze AVPR1A microsatellites (RS1 and RS3). Both length variants were found to be associated with restrictive, repetitive behaviors, but not overall diagnosis. Correction for multiple comparisons was performed for SNPs tested in each gene region, only AVPR1B SNPs remained significantly associated with ASD diagnosis.Conclusions: Autism is a heterogeneous disorder with many genes and pathways that contribute to its development. SNPs and microsatellites in the receptor genes of OT and AVP are associated with ASD diagnosis and measures of social behavior as well as restricted repetitive behaviors. We reported a novel association with ASD and AVPR1B SNPs. Understanding of genotype-phenotype relationships may be helpful in the development of pharmacological interventions for the OT/AVP system.

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Section: Discussionsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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ASD and Genetic Associations with Receptors for Oxytocin and Vasopressin—AVPR1A, AVPR1B, and OXTR

et al. 2016

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“…The degree of behavioral response depends upon early social experience. The V1bR also has a role to play in modulating aggression in males (54). Aggressive behavior in females is not normally observed in response to AVP (55).…”

Section: Vasopressinmentioning

confidence: 99%

Genetic Influences on Social Cognition

Skuse

Gallagher

2011

Pediatric Research

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Human social behavior develops under the influence of genetic, environmental, and cultural factors. Social cognition comprises our ability to understand and respond appropriately to other people's social approaches or responses. The concept embraces self-knowledge and theory of mind, or the ability to think about emotions and behavior from the perspective of another person. The neuropeptides oxytocin (OT) and vasopressin (AVP) are now known to play an important role, affecting individual differences in parenting behavior, social recognition, and affiliative behaviors. The processes of social cognition are also supported by reward circuitry, underpinned by the dopaminergic neurotransmitter system. Reward processes build social relationships, in parenting and pair-bonding, and influence social interactions that require trust, or display altruism. The impact of emotional regulation upon social behavior, including mood and anxiety, is also mediated through the serotonergic system. Variation in activity of serotonergic networks in the brain influences emotional responsivity, including subjective feelings, physiological responses, emotional expressions, and the tendency to become engaged in action as a consequence of a feeling state. Genetic variation in the receptors associated with OT, AVP, dopamine, and serotonin has been intensively studied in humans and animal models. Recent findings are building an increasingly coherent picture of regulatory mechanisms. (Pediatr Res 69: 85R-91R, 2011) W e, as humans, usually possess the ability to rapidly process social information about the thoughts and actions of other people and to interact in complex ways with them. Social cognition comprises a set of skills that enable us to understand thoughts and intentions that may differ from our own experiences or predispositions. As we develop through early childhood, we are increasingly capable of taking another person's perspective, and we develop self-knowledge. We can accurately predict how another person might behave in the future, from our social perceptions and experiences. We become capable of learning what motivates other people in their social interactions, even if these do not directly involve us. All these skills map onto schemas that are encoded in an associative network in memory and is orchestrated to ensure normal, skilled social adaptation (1).The process by which we acquire social cognitive competence evolves with development and is modified in response to the environment. To begin with, infants cannot easily differentiate between themselves and other people, but they rapidly become aware that their actions have an impact on the physical and social world around them. In due course, they develop social understanding, language, and imitation. Eventually, most of us acquire the ability to "read the mind" of others. By this, we mean that it becomes possible for us to understand why other people behave the way they do and to respond appropriately to them in social situations. If we have not acquired this ability...

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“…The AVP-ergic projections from the BNST and MeA to the lateral septum (LS) are also important for aggression and are strongly androgen-dependent, as surveyed by Caldwell et al [8]. Numerous studies suggest mediating functions of AVPR1B receptors in aggression [30] and indicate that the interconnecting 5-HT-ergic elements decrease AVPfacilitated aggression [31]. Furthermore, AVP is involved in affiliation such as pair bonding, or paternal or maternal care [8].…”

Section: Behavioral Consequences Of Avpmentioning

confidence: 99%

Study of neurogenic involvement in arginine-vasopressin and oxytocin release under basal and environmentally stimulated conditions

Nagyéri¹

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Social dominance in male vasopressin 1b receptor knockout mice

Cited by 34 publications

References 41 publications

ASD and Genetic Associations with Receptors for Oxytocin and Vasopressin—AVPR1A, AVPR1B, and OXTR

ASD and Genetic Associations with Receptors for Oxytocin and Vasopressin—AVPR1A, AVPR1B, and OXTR

Genetic Influences on Social Cognition

Study of neurogenic involvement in arginine-vasopressin and oxytocin release under basal and environmentally stimulated conditions

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