Social jet-lag potentiates obesity and metabolic syndrome when combined with cafeteria diet in rats

Espítia‐Bautista, Estefania; Velasco-Ramos, Mario; Osnaya-Ramírez, Iván; Ángeles-Castellanos, Manuel; Buijs, Ruud M.; Escobar, Carolina

doi:10.1016/j.metabol.2017.04.006

Cited by 41 publications

(25 citation statements)

References 52 publications

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“…Until now, few studies have evaluated the effects of social jetlag on food intake. A study on rats showed that the combination of social jetlag and a cafeteria diet (rich in fat and carbohydrates) led the animals to overeat and also increased their bodyweight and the number of criteria indicating metabolic syndrome [5]. In humans, a study conducted by our research group on Brazilian undergraduate students found that social jetlag was negatively associated with the consumption of beans [14], a typical constituent of the Brazilian diet that has been associated with protection against overweight [24].…”

Section: Discussionmentioning

confidence: 99%

“…The need to balance biological preferences with the requirements to meet pre-established working or study schedules can promote disruption of the circadian timing that alters sleep onset and wake up time between weekdays and weekends, producing a condition termed social jetlag [4,5]. Specifically, social jetlag reflects the difference in sleeping and waking hours on free days (determined by individual preference) and work days (established by social demands, that is, by schedules for working or studying) [4, 6].…”

Section: Introductionmentioning

confidence: 99%

“…Despite the scarcity of studies explaining the possible role of social jetlag in the development of overweight and related diseases, studies have suggested that the circadian misalignment measured by social jetlag can compromise the maintenance of a healthy lifestyle, especially the behaviors related to tobacco consumption [10], physical activity [12] and feeding behavior [13, 14]. In this sense, studies have indicated that social jetlag could determine meal schedules, promoting food consumption at an inappropriate circadian time, as well as the intake of highly caloric or unhealthy food [5,14].…”

Section: Introductionmentioning

confidence: 99%

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Association between social jetlag food consumption and meal times in patients with obesity-related chronic diseases

et al. 2019

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Chronic disruption of the synchronous relationship between endogenous and exogenous circadian timing is associated with the development of obesity and metabolic disease. Social jetlag is a measure of circadian misalignment and has been identified as a risk factor for overweight and related diseases. However, the mechanisms involved in this relationship remain underexplored. The objective of this study was to investigate the association between social jetlag and food consumption at late meal timing in patients with obesity-related chronic diseases. This study included 792 individuals (73% female; age 55.9 ± 12.4 years) in which the prevalence of social jetlag (>1h) was 24.4% (n = 194). Participants with social jetlag reported late meal timing for breakfast, early afternoon snack and dinner. Individuals with social jetlag also reported a higher intake of total calories (kcal), protein, total fat, saturated fat, cholesterol, and servings of meat and eggs and sweets in relation to those without social jetlag. Regarding the consumption during each meal of the day, participants with social jetlag had consumed more calories, saturated fat and cholesterol during dinner; more protein, total fat, saturated fat, and cholesterol during lunch; and more total fat and saturated fat during morning snack. In addition, individuals with social jetlag had a higher risk of inadequate consumption of total fat, saturated fat and cholesterol intake when compared with those without social jetlag. We conclude that social jetlag is associated with a poor diet and later meal times, which should be avoided in individuals with obesity-related chronic diseases. More studies are needed to confirm these findings.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between social jetlag food consumption and meal times in patients with obesity-related chronic diseases

et al. 2019

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“…It was observed in an experiment that social jet lag potentiated body weight gain by increasing overconsumption of cafeteria food. As a result, it promoted high insulin and dyslipidemia indicating the risk of metabolic syndrome [ 55 ]. A chronic shift in light/dark (LD) cycles induces obesity, increases body weight and glucose intolerance, and accumulates more fat in white adipose tissues.…”

Section: Shiftwork Dysregulates Metabolic Process and Develops Relmentioning

confidence: 99%

Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep Homeostasis Cause Serious Health Problems

Khan

Duan

Yao

et al. 2018

International Journal of Genomics

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Shiftwork became common during the last few decades with the growing demands of human life. Despite the social inactivity and irregularity in habits, working in continuous irregular shifts causes serious health issues including sleep disorders, psychiatric disorders, cancer, and metabolic disorders. These health problems arise due to the disruption in circadian clock system, which is associated with alterations in genetic expressions. Alteration in clock controlling genes further affects genes linked with disorders including major depression disorder, bipolar disorder, phase delay and phase advance sleep syndromes, breast cancer, and colon cancer. A diverse research work is needed focusing on broad spectrum changes caused by jet lag in brain and neuronal system. This review is an attempt to motivate the researchers to conduct advanced studies in this area to identify the risk factors and mechanisms. Its goal is extended to make the shift workers aware about the risks associated with shiftwork.

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“…Shift-work: is time of eating determining metabolic health? Espitia-Bautista et al (23) DD, constant dark; GTT, glucose tolerance test; HFD, high-fat diet; LD, light-dark; NE, not explored; REM, rapid eye movement; SCN, suprachiasmatic nucleus; UPR, unfolded protein response; VLPO, ventrolateral preoptic nucleus; =, similar to controls; ↑ increased; ↓decreased.…”

Section: Experimental Models Of Forced Activitymentioning

confidence: 99%

Shift-work: is time of eating determining metabolic health? Evidence from animal models

et al. 2018

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The circadian disruption in shift-workers is suggested to be a risk factor to develop overweight and metabolic dysfunction. The conflicting time signals given by shifted activity, shifted food intake and exposure to light at night occurring in the shift-worker are proposed to be the cause for the loss of internal synchrony and the consequent adverse effects on body weight and metabolism. Because food elicited signals have proven to be potent entraining signals for peripheral oscillations, here we review the findings from experimental models of shift-work and verify whether they provide evidence about the causal association between shifted feeding schedules, circadian disruption and altered metabolism. We found mainly four experimental models that mimic the conditions of shift-work: protocols of forced sleep deprivation, of forced activity during the normal rest phase, exposure to light at night and shifted food timing. A big variability in the intensity and duration of the protocols was observed, which led to a diversity of effects. A common result was the disruption of temporal patterns of activity; however, not all studies explored the temporal patterns of food intake. According to studies that evaluate time of food intake as an experimental model of shift-work and studies that evaluate shifted food consumption, time of food intake may be a determining factor for the loss of balance at the circadian and metabolic level.

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Social jet-lag potentiates obesity and metabolic syndrome when combined with cafeteria diet in rats

Cited by 41 publications

References 52 publications

Association between social jetlag food consumption and meal times in patients with obesity-related chronic diseases

Association between social jetlag food consumption and meal times in patients with obesity-related chronic diseases

Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep Homeostasis Cause Serious Health Problems

Shift-work: is time of eating determining metabolic health? Evidence from animal models

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