Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep Homeostasis Cause Serious Health Problems

Khan, Suliman; Duan, Pengfei; Yao, Lunguang; Hou, Hongwei

doi:10.1155/2018/8576890

Cited by 89 publications

(72 citation statements)

References 118 publications

(150 reference statements)

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“…Many of past studies have agreed that disruption of the circadian system is seen as relevant for shift workers, putting them at a major risk to be affected by health impairment. A recent review done by Khan et al (2018) reported that despite the social inactivity and irregularity in habits, working in continuous irregular shifts causes serious health issues including sleep disorders, psychiatric disorders, cancer, and metabolic disorders.…”

Section: Circadian Disruption Among Shift Workersmentioning

confidence: 99%

The Effects of Circadian Rhythm Disruption towards Metabolic Stress and Mental Health: A Review

Ahmad

2020

JSKM

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This review aims to present an overview of current research findings on the possible effects of circadian rhythm (CR) disruption towards metabolic stress and mental health. CR can be described as an internal biological clock that regulates our body functions, based on our sleep/wake cycle. Any time that our normal 24-hour circadian rhythm is altered or interrupted, it will have physiological and psychological impacts. However, in today's demanding working world, most of us are working defying the normal conditions without realising the significant drawbacks of it. Therefore, this review summarises the findings from several researches on the physiological (metabolic stress) and psychological (cognitive functioning and mental health) impacts of the CR disruption in order to assist people to have a holistic view on the effects of CR to our mind and body. Evidences that linked these aspects to health circumstances of shift workers have also been highlighted.ABSTRAK Tinjauan ini bertujuan untuk menunjukkan gambaran keseluruhan penemuan penyelidikan semasa mengenai kesan gangguan ritma sirkadian (RS) terhadap stres metabolik dan kesihatan mental. Ritma sirkadian (RS) didefinisikan sebagai jam biologi dalaman yang mengawal fungsi badan kita berdasarkan kitaran tidur/jaga kita. Jika RS 24-jam kita yang biasa terganggu, ia akan memberi kesan kepada sistem fisiologi dan psikologi kita. Walau bagaimanapun, dalam era globalisasi ini, kebanyakan individu bekerja pada luar waktu normal tanpa menyedari kesan buruknya. Oleh itu, tinjauan ini merumuskan penemuan daripada beberapa kajian mengenai kesan gangguan RS terhadap sistem fisiologi (stres metabolik) dan psikologi (fungsi kognitif dan kesihatan mental) kita agar dapat membantu masyarakat kita untuk mempunyai pandangan holistik terhadap kesan RS ke atas minda dan badan kita. Kesimpulan yang menghubungkan aspek-aspek ini dengan keadaan kesihatan pekerja syif juga telah dibincangkan.

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Section: Circadian Disruption Among Shift Workersmentioning

confidence: 99%

The Effects of Circadian Rhythm Disruption towards Metabolic Stress and Mental Health: A Review

Ahmad

2020

JSKM

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“…In recent years, people's sleep time has shown a downward trend. The average daily sleep time of Chinese residents is 7.20 h, and the proportion of people with sleep insufficiency is 23.60% (47). Similarly, the proportion of young Americans who sleep for less than 7 hours/day has risen from 15.6% to 37.1% in the last 40 years (48).…”

Section: Sleep-related Factorsmentioning

confidence: 99%

Environmental factors and life style having an impact on pathogenesis and etiology of Diabetes Mellitus

Kumar

Perswani²,

Memon³

et al. 2019

ijmsci

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Type 2 diabetes mellitus (T2DM) is currently a public health problem worldwide and a threat to human health and social development. The incidence rate of the disease is steadily increasing. Various genetic and environmental factors have been established as influencing the pathogenesis of this disease. However, the influence of social factors and the natural environment on DM incidence should also be considered. Low-grade inflammation could represent a central point of connection integrating all these potential triggers, being partly responsible for the development of insulin resistance. This paper aims to elaborate on the impact of the natural environment and social factors on DM development, with a special focus on six aspects of the pathogenesis of DM: pollution, radiation, psychology, drink, sleep, and exercise. We identified a two-way relationship between T2DM and social and natural environments. Changes in these environments may lead to low-grade inflammation, which in turn induces or aggravates T2DM and vice versa. Poor lifestyle may lead to increased insulin resistance and promote DM development. Improvements in blood glucose control can be achieved through non-environmental and behavioral interventions.

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“…Surprisingly, Per1 and Per2 behave differently during phase shifts (jet lag or shiftwork) 6 , 25 that may ultimately cause the disruption in the circadian clock. Along with sleep regulation, circadian rhythms also direct normal physiological processes, including hormone secretion, body temperature, feeding behavior, cell-cycle progression and drug, glucose and xenobiotic metabolism 10 , 22 .…”

Section: Circadian Systemmentioning

confidence: 99%

“…Long-term exposure to irregular dark-light cycles increases the risk of sleep disorders, metabolic disorders, mental abnormalities, depressive disorders, and hormonal abnormalities, that further develop cancer, gastrointestinal, and reproductive disorders 10 . Trans meridian travel may develop general malaise, headaches, insomnia, daytime sleepiness, impaired cognitive or physical performance and gastrointestinal disturbances.…”

Section: Introductionmentioning

confidence: 99%

Health risks associated with genetic alterations in internal clock system by external factors

Khan¹,

Nabi²,

Yao³

et al. 2018

Int. J. Biol. Sci.

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The circadian system maintains the main aspects of physiological and behavioral processes. Both circadian rhythm and sleep impact an organism's health through interaction with environmental factors. Variations in external factors influence the functionality of clock genes and disrupt 24-hour rhythmic cycle. The disrupted circadian rhythm and disregulated sleep affect an organism's health, thereby causing several disorders including cancer, depression and cardiac disorders. Considering the role of clock genes and environmental factors, extensive investigation is required focusing on pathways involved in development of life-threatening disorders. This review identifies the major risks and associated factors related with disruption in circadian system and sleep.

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Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep Homeostasis Cause Serious Health Problems

Cited by 89 publications

References 118 publications

The Effects of Circadian Rhythm Disruption towards Metabolic Stress and Mental Health: A Review

The Effects of Circadian Rhythm Disruption towards Metabolic Stress and Mental Health: A Review

Environmental factors and life style having an impact on pathogenesis and etiology of Diabetes Mellitus

Health risks associated with genetic alterations in internal clock system by external factors

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