The Effects of Circadian Rhythm Disruption towards Metabolic Stress and Mental Health: A Review

Ahmad, Mahadir

doi:10.17576/jskm-2020-1801-07

Cited by 4 publications

(3 citation statements)

References 85 publications

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“…Therefore, particular attention must be given to children's sleep patterns also (Sato and Ida, 2017). Chrono-disruption is the misalignment of peripheral clocks with the central clock (Garaulet et al, 2010), which leads to some serious diseases (Ahmad, 2020). Majority of diseases are lifestyle disorders such as cardiovascular diseases, depression, obesity and metabolism (Garaulet et al, 2014) (Fig.…”

Section: Impacts Of Clock Disrupters A) Metabolic Imbalancesmentioning

confidence: 99%

“…Shifting school timings to later hours is a practical approach because misalignment of the sleep schedule with the school timing, if carried over for a prolonged period, will result in regularly persistent and irrefutable sleep-debt. Adolescents already undergo tremendous developmental changes on the level of their brain and body, and in addition to it, if they will not get proper sleep to rejuvenate, then this chronic sleep debt may hamper their emotional, mental, physiological and metabolic well-being on a serious note (Hansen et al, 2005;Giedd, 2009;Giedd et al, 2012;Sawyer et al, 2012;Sørensen et al, 2012;Foster et al, 2013;Ahmad, 2020). Alignment of the biological and school clock will help adolescents in improving their health, along with the better academic performance that too in a relatively less stressed atmosphere (Ward, 2021).…”

Section: A Suggestive Solutionmentioning

confidence: 99%

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Biological clock vs Social clock conflict in Adolescents

Verma

Yadav

Rani

et al. 2021

JANS

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Alteration of day and night is one of the essential circadian rhythms that build the phenomenon of sleep/wake in humans and other animals. Daily rhythms impact different individuals differently. Light exposure and an individual's circadian response are two aspects that create diversity in phenotype. These diverse phenotypes are called chronotypes. Chronotype varies over the life history stages. Chronotype is seen as morning type in children, evening type in adolescents, and again reverts back to the morning type in adults and old-aged individuals. It is observed that adolescents being evening types have bedtime later in comparison to children and adults. Adolescent physiology/ body clock does not allow them to sleep early and school routine/social clock does not let them sleep till late. Thus, their night phase is shrunk and sleep hours are reduced, which hinders their day-time functioning, including mental tasks such as cognition, learning and memory-based exercises, and physical tasks such as physical presence during field and athletic events. These days sleep debt is a critical health concern in the adolescent population. The current review focuses on the adolescent sleep-needs and various factors affecting their healthy sleep. This also encompasses the understanding of biological clocks, their misalignment, disrupters, causes and impact. The present study would be helpful in finding out the difference between the biological clock and social clock of the adolescent population, elaborates the need for sleep education and suggests a solution to this alarming problem of sleep debt in teens.

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Section: Impacts Of Clock Disrupters A) Metabolic Imbalancesmentioning

confidence: 99%

Section: A Suggestive Solutionmentioning

confidence: 99%

Biological clock vs Social clock conflict in Adolescents

Verma

Yadav

Rani

et al. 2021

JANS

View full text Add to dashboard Cite

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“…These toxins promote the hormonal release, the production of reactive oxygen species (ROS), hypoxia, as well as cell swelling (Wellen et al, 2010). Also, metabolic stress is allied with other diseases like obesity ; aging ; circadian rhythm (Ahmad., 2020); autophagy (Kalra et al, 2022); cardiomyopathy (Liu et al, 2017); inflammatory bowel disease (Schoultz et al, 2011); diabetes ; cognitive impairment , etc. Numerous studies in AD suggest a connection between Aβ oligomers and disease progression.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Metabolic Disorders and FOXO Signaling in AD: A Therapeutic Approach

Kaur

Khan

Grewal

et al. 2023

Preprint

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Alzheimer’s Disease is an ailment that is linked with the degeneration of the brain cells and this illness is the main cause of dementia. Metabolic stress affects the activity of the brain in AD via FOXO signaling. The occurrence of AD will significantly surge as the world’s population will age along with lifestyle changes perceived in current decades giving the impression of main contributors to such augmented prevalence. Similarly, metabolic disorders of current adulthood, such as obesity, liver, stroke, and diabetes mellitus, have been observed as the risk-causing factors of AD. FOXO transcription factors are preserved molecules that play an important part in assorted biological progressions, precisely in aging as well as metabolism. Here, we capitulate the signaling pathways along with the cellular functions of FOXO proteins. We have also summarized the intricate role of FOXO in AD, with a focus on metabolic stress, and discussed the prospect of transcriptional alterations with respect to FOXO as a molecular link between AD and metabolic disorders.

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