The role of the intestinal microbiota in the pathogenesis of host depression and mechanism of TPs relieving depression

Yang, Ligong; Wu, Zufang; Liu, Cheng; Zhang, Xin; Yang, Haining

doi:10.1039/d1fo01091c

Cited by 23 publications

(14 citation statements)

References 103 publications

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“…Dietary polyphenols have been found to act as neuroprotectants that possess pharmacological effects on the CNS for relieving anxiety and mitigating depression [125]. Robust evidence corroborates a bidirectional link between sleep disturbance and depression, also circadian dysregulation is one of the critical pathogenetic of depression nowadays.…”

Section: The Regulation Of Depression By Plant Polyphenols Through In...mentioning

confidence: 94%

The Intervention of Prebiotics on Depression via the Gut–Brain Axis

He¹,

Si²,

Sun³

et al. 2022

Molecules

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The imbalance of intestinal microbiota can cause the accumulation of endotoxin in the main circulation system of the human body, which has a great impact on human health. Increased work and life pressure have led to a rise in the number of people falling into depression, which has also reduced their quality of life. The gut–brain axis (GBA) is closely related to the pathological basis of depression, and intestinal microbiota can improve depressive symptoms through GBA. Previous studies have proven that prebiotics can modulate intestinal microbiota and thus participate in human health regulation. We reviewed the regulatory mechanism of intestinal microbiota on depression through GBA, and discussed the effects of prebiotics, including plant polysaccharides and polyphenols on the regulation of intestinal microbiota, providing new clues for the prevention and treatment of depression.

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Section: The Regulation Of Depression By Plant Polyphenols Through In...mentioning

confidence: 94%

The Intervention of Prebiotics on Depression via the Gut–Brain Axis

He¹,

Si²,

Sun³

et al. 2022

Molecules

Self Cite

View full text Add to dashboard Cite

show abstract

“…The main mechanisms of polyphenols reducing depression are related to lowering oxidative stress and neuroinflammation, and increasing neurotrophin release. The processes proposed seem to also have an impact on serotonin, norepinephrine, and/or dopaminergic systems regulation to influence the HPA axis and modify the concentration of the BDNF [ 107 ], mitogen-activated protein kinase phosphatase-1 (MKP-1), and cAMP-responsive element-binding protein (CREB), and to normalize phosphorylation levels in the hippocampus, prefrontal cortex-modulating synaptic plasticity, activation of neuroplasticity, neurogenesis, and cell survival signaling pathways (PKA, CaMKII, PKC, MAPK/ERK, and PI3K) [ 108 ]. The use of dietary polyphenols to target various cell signaling pathways related to oxidative stress and inflammation, including MAPK, NFκB, and PI3K/Akt, is becoming a new method for preventing and treating depressive disorders.…”

Section: Antidepressant Effects Of Nutraceuticalsmentioning

confidence: 99%

Nutraceuticals and Physical Activity as Antidepressants: The Central Role of the Gut Microbiota

et al. 2022

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Major depressive disorder (MDD) is a common mental illness. Evidence suggests that the gut microbiota play an essential role in regulating brain functions and the pathogenesis of neuropsychiatric diseases, including MDD. There are numerous mechanisms through which the gut microbiota and brain can exchange information in a continuous, bidirectional communication. Current research emphasizes the interexchange of signals influenced by the gut microbiota that are detected and transduced in information from the gut to the nervous system involving neural, endocrine, and inflammatory mechanisms, suggesting a relationship between oxidative stress and the pathophysiology of MDD via the hyperactivation of inflammatory responses. Potential sources of inflammation in the plasma and hippocampus of depressed individuals could stem from increases in intestinal permeability. Some nutraceuticals, such as specific probiotics, namely psychobiotics, polyphenols, carotenoids, butyrate, and prebiotics, have been demonstrated to exert an antidepressant activity, but most of them need to be metabolized and activated by gut microorganisms. By inducing changes in the gut microbiota composition, physical exercise might also exert a role in alleviating depression-like symptoms. The mutual relationships among nutraceuticals, exercise, and depression will be discussed, and the potential role of the gut microbiota as a therapeutic target to treat depression will be explored.

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“…The prevalence of depression in the general population during the COVID-19 outbreak is 25% ( 84 ). Alterations in the composition of the gut microbiota can increase the permeability of the gut barrier, activate systemic inflammatory and immune responses, modulate the release and efficacy of monoamine neurotransmitters, alter the activity of the hypothalamic-pituitary-adrenal axis and function, and alters the abundance of brain-derived neurotrophic factor (BDNF) ( 85 ). A deficiency of BDNF may lead to neuroplasticity impairment and depression.…”

Section: Reduction Of Covid-19 Comorbidity Risk By Tpsmentioning

confidence: 99%

Potential Application of Tea Polyphenols to the Prevention of COVID-19 Infection: Based on the Gut-Lung Axis

Liu

et al. 2022

Front. Nutr.

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Coronavirus disease 2019 (COVID-19) disrupts the intestinal micro-ecological balance, and patients often develop the intestinal disease. The gut is the largest immune organ in the human body; intestinal microbes can affect the immune function of the lungs through the gut-lung axis. It has been reported that tea polyphenols (TPs) have antiviral and prebiotic activity. In this review, we discussed TPs reduced lung-related diseases through gut-lung axis by inhibiting dysbiosis. In addition, we also highlighted the preventive and therapeutic effects of TPs on COVID-19 complications, further demonstrating the importance of research on TPs for the prevention and treatment of COVID-19 in humans. Based on this understanding, we recommend using TPs to regulate the gut microbiota to prevent or alleviate COVID-19 through the gut-lung axis.

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The role of the intestinal microbiota in the pathogenesis of host depression and mechanism of TPs relieving depression

Abstract: Depression is a prevalent neuropsychiatric disease with a high recurrence rate, affecting over 350 million people worldwide. Intestinal flora disorders and gut-brain-axis (GBA) dysfunction may cause mental disorders. Alterations in...

Cited by 23 publications

References 103 publications

The Intervention of Prebiotics on Depression via the Gut–Brain Axis

The Intervention of Prebiotics on Depression via the Gut–Brain Axis

Nutraceuticals and Physical Activity as Antidepressants: The Central Role of the Gut Microbiota

Potential Application of Tea Polyphenols to the Prevention of COVID-19 Infection: Based on the Gut-Lung Axis

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