Packaging design in modern society has not only met people's needs for packaging, but also gradually integrated into the appreciation value of goods, becoming an integral part of goods. Polymer materials have become the mainstream materials in electronic packaging due to their light weight, good corrosion resistance and insulation properties. However, the thermal conductivity of polymer packaging materials is poor. A lot of attempts have been made to improve the thermal conductivity of packaging polymers. Nanofiber materials are added to polymers to improve their performance. In this paper, the combination of oil painting art and newly developed diamond nano cellulose is applied to packaging design, which can not only make the packaging flash the charm of color, but also increase the cultural atmosphere, so oil painting art has an important application in packaging design. In this paper, oxidized nano cellulose was prepared from bleached eucalyptus pulp and waste newspaper. The results showed that the effect of adding oxidized nano cellulose was better, and the addition of cationic starch could promote the strength of paper. Among them, oxidized nano cellulose can increase the tensile index, burst index and tear index of packaging paper by 4.8%, 9.25% and 2.29% respectively. In view of this, on the basis of expounding the characteristics of oil painting art, this paper deeply analyzed the integration concept of oil painting art and nano cellulose in oil painting art and souvenir packaging design. After that, it discussed the relevant strategies with examples, hoping to play a reference role for modern packaging design.