Social rejection following neonatal inflammation is mediated by olfactory scent cues

MacRae, M.; Kenkel, William M.; Kentner, Amanda C.

doi:10.1016/j.bbi.2015.02.026

Cited by 15 publications

(4 citation statements)

References 22 publications

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“…Our previous work suggests that overall decreased social interaction following early-life inflammation is due to reduced contact directed toward gestational and neonatally treated LPS male rats (Connors et al, 2014;MacRae et al, 2015). We show this here, but in both male and female neonatally challenged animals.…”

Section: Considerations Of Timesupporting

confidence: 44%

Tracing the trajectory of behavioral impairments and oxidative stress in an animal model of neonatal inflammation

et al. 2015

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Section: Considerations Of Timesupporting

confidence: 44%

Tracing the trajectory of behavioral impairments and oxidative stress in an animal model of neonatal inflammation

et al. 2015

Self Cite

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“…Thus, these studies are reviewed here in somewhat greater detail. No significant links between immune function and USV were found in the two publications that we could trace dealing with early postnatal immune stimulation . The few reports available on ultrasonic calling and stimulation of the immune system during experimentally induced inflammatory or autoimmune processes are mentioned below.…”

Section: Immune Activation and Vocalizationmentioning

confidence: 88%

Immunity and ultrasonic vocalization in rodents

Jouda

Wöhr

Rey

2018

Annals of the New York Academy of Sciences

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Ultrasonic vocalizations (USVs) serve important communicative functions in rodents. Different types of USVs can be triggered in the sender, for example, by maternal separation, social interactions, or exposure to predators, and they evoke affiliative or alarming behaviors in recipients. This review focusses on studies evaluating possible links between immunity and USVs. Most studies have been performed in a murine model of maternal immune activation and subsequent evaluation of effects in the offspring. This model has received large attention in recent years because it mimics behavioral abnormalities observed in certain human neuropsychiatric disorders, including autism spectrum disorder. Although there is still some controversy, the results indicate that stimulation of the immune system of mice and rats during pregnancy affects ultrasonic calling in pups. Few studies are available on immunization during adulthood and USVs. In most cases, immune stimulation led to disease, complicating conclusions about a possible direct link between vocalization and immunity. Although much work is still needed, this is certainly a rather new and promising aspect of interactions between the immune system and behavior.

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“…Further, GF mice exhibit reduced digestive enzyme activity, lymphoid tissue, and resistance to infection (reviewed in Yoon et al (2014)), therefore, the connections between the immune system and the microbiome appear to be extremely complex. Interestingly, male and female Sprague–Dawley rats treated with LPS as neonates show reduced social contact time, however, when olfactory processing is disrupted, the deficits in social contact are reversed (MacRae et al, 2015). These data suggest that the interactions between the microbiota and the immunomodulatory scent signals may modulate the changes in social interactions following neonatal sickness, however, precisely how the microbiome is affected by neonatal inflammation is not completely understood.…”

Section: Introductionmentioning

confidence: 99%

Early-life sickness may predispose Siberian hamsters to behavioral changes following alterations of the gut microbiome in adulthood

Sylvia

Deyoe

Demas

2018

Brain, Behavior, and Immunity

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Although it is well-established that the immune system plays an important role in the development of physiology and behavior, the gut microbiome has recently become of interest in the study of developmental origins of behavior. Studies suggest that the effects of early-life immune activation may not occur until a secondary stressor is introduced, though the precise nature and timing of the stressor may be critical in the response. Further, recent work suggests that the microbiome and the immune system develop in parallel, and therefore any perturbations to one of these systems early in life will likely affect the other. Here, we sought to determine whether early-life activation of the immune system had long-term consequences on how the gut microbiome responds to antibiotic treatment in adulthood and whether those changes influence adult same-sex social behavior. In order to test the hypothesis that an early-life immune challenge makes individuals more vulnerable to the effects of antibiotics, we mimicked an early-life infection by injecting pups at postnatal day 3 and 5 with lipopolysaccharide (LPS; cell wall component of gram-negative bacteria) or saline, and subsequently exposed the same animals to antibiotic treatment (known to influence microbial community composition and behavior) or water in adulthood. We tracked physiology across development, and paired males and females with a novel individual of the same age and sex in adulthood to score same-sex behavior (e.g., aggression, investigation, grooming) before antibiotic treatment, immediately following treatment, and after recovery from antibiotics. LPS-treated females exhibited impaired reproductive physiology and function in adulthood (e.g., smaller ovaries and abnormal estrous cycles), and female and male gut microbial communities were strongly affected by antibiotic treatment in adulthood, but only slightly affected by postnatal LPS alone. Interestingly, LPS-treated males exhibited more robust changes in their behavioral response following adult antibiotic treatment, including decreased investigation and increased grooming, suggestive of changes in anxiety-like behaviors. These data suggest that males may be more vulnerable than females to behavioral abnormalities after being predisposed to an immune challenge early in life. Collectively, these results provide novel evidence that some of the sex-specific behavioral consequences of an early-life immune challenge may not transpire until an individual is faced with a secondary challenge, and the context in which an individual is exposed can greatly influence the response.

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Social rejection following neonatal inflammation is mediated by olfactory scent cues

Cited by 15 publications

References 22 publications

Tracing the trajectory of behavioral impairments and oxidative stress in an animal model of neonatal inflammation

Tracing the trajectory of behavioral impairments and oxidative stress in an animal model of neonatal inflammation

Immunity and ultrasonic vocalization in rodents

Early-life sickness may predispose Siberian hamsters to behavioral changes following alterations of the gut microbiome in adulthood

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