Social stress paradigms in male mice: Variations in behavior, stress and immunology

Fano, Eduardo; Sánchez-Martín, José R.; Arregi, Amaia; Castro, Begoña; Alonso, Ana; Brain, Paul F.; Azpı́roz, Arantza

doi:10.1016/s0031-9384(01)00445-0

Cited by 33 publications

(11 citation statements)

References 34 publications

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“…Immune reaction stimulation is observed for the aggressive animals (agnostic type behavior), and immune reaction suppression is observed for the submissive animals (submissive type behavior) [17,19,20]. There are experimentally observed differences in the interleukins IL1 and IL2 secretion related to the different aspects of social stress (cohabitation, dyadic collisions) [21]. It was also determined that changes in the immune response were dependent not only upon stress duration [22] and intensity [23] but also on the presence of psychological discomfort caused by the infantilism of the psychological defense mechanisms [24][25][26].…”

Section: Analysis Of the Hypotheses Basing On The Available Expermentioning

confidence: 99%

Psycho-immune Partnership in the Dynamic Responses of Living Systems

Koptyug²,

Petrov³

et al. 2014

LSMR

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Abstract-Present paper outlines certain possibilities for a new approach to the generalized modeling of the dynamics of living organism reaction to the changes in its environment. It is shown that there exists common functional "alignment" of the immune and psychic responses in the living organism reaction to the changes in the environment. This is manifested in the experimentally recorded matching of the response scenarios and activities in the immune and psychic domains. Thus, one may conclude that there exist two functionally matched systems (psychic and immune) tracking the external influences and responding to them. On the other hand it is feasible that one is actually dealing with a complex inseparable psycho-immune system and experimentally monitors different aspects of its activity describing these from two different points of view. Given analysis of available experimental data seems to support both of the above alternatives without giving undoubted preferences to any of them. However treating the situation form the formal logic point of view certain preferences can be given to the concept of an inseparable psycho-immune system modeled in two different ways. This approach can also resolve certain collisions happening with the attempts to describe direct interrelations between psychic and immune domains, and can lead the way to higher-level functionality models of the dynamic responses of the living organisms.

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Section: Analysis Of the Hypotheses Basing On The Available Expermentioning

confidence: 99%

Psycho-immune Partnership in the Dynamic Responses of Living Systems

Koptyug²,

Petrov³

et al. 2014

LSMR

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“…IL-2, a cytokine that plays a role in T-cell activation, and IL-8, a cytokine that recruits neutrophils to inflammation sites, also provide a measure of cell-mediated immunity (Janeway et al, 2005). However, the three studies that investigated these cytokines failed to show a consistent relationship with social status (Bartolomucci et al, 2001;Fano et al, 2001;Hoffman et al, 2011).…”

Section: Other Animalsmentioning

confidence: 99%

Social status, glucocorticoids, immune function, and health: Can animal studies help us understand human socioeconomic-status-related health disparities?

Cavigelli

Chaudhry

2012

Hormones and Behavior

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“…Due to their fully characterized genome, robust behavioral responses and high-throughput nature, zebrafish (Danio rerio) have emerged as a complementary model in biomedical research Kyzar et al, 2012;Stewart et al, 2011). While primates and rodents have traditionally been utilized to study the genetic and neural underpinning of social interactions (Fano et al, 2001;Ribeiro Do Couto et al, 2009;Sassenrath and Chapman, 1976), zebrafish can also be used for examining both normal and aberrant social behavior (Miller and Gerlai, 2007). Shoaling, an important evolutionarily conserved behavior, has long been identified in zebrafish (Mc and Bradner, 1998;Reyhanian et al, 2011;Ward et al, 2008), representing the interaction of a number of animals moving together in coordinated movements (Buske and Gerlai, 2011b;Krause et al, 2000).…”

Section: Introductionmentioning

confidence: 99%