Socioeconomic and Clinical Factors Influence the Interval Between Positive Prostate Biopsy and Radical Prostatectomy

Pitman, Max; Korets, Ruslan; Kates, Max; Hruby, Gregory W.; McKiernan, James M.

doi:10.1016/j.urology.2012.01.008

Cited by 16 publications

(10 citation statements)

References 28 publications

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“…On the one hand, delay may be due to a worse awareness and appraisal of cancer symptoms, on the other hand due to more barriers regarding access to screening programs , and health care in general which in turn lead to small chances of incidental findings. It was shown that cancer awareness is lower in more deprived groups (Robb et al, 2009), but a recent study found out that lower SES may predict a longer interval between prostate biopsy and treatment (radical prostatectomy) (Pitman et al, 2012). Indeed, current findings hardly suggest an association between curative treatment delay and survival (Redaniel et al, 2013;van den Bergh et al, 2013).…”

Section: Discussionmentioning

confidence: 89%

Socioeconomic inequalities in prostate cancer survival: A review of the evidence and explanatory factors

Klein

Knesebeck

2015

Social Science & Medicine

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Section: Discussionmentioning

confidence: 89%

Socioeconomic inequalities in prostate cancer survival: A review of the evidence and explanatory factors

Klein

Knesebeck

2015

Social Science & Medicine

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“…20 Pitman et al found that African American and Hispanic men wait longer between positive prostate biopsy results and radical prostatectomy than white men. 21 However, it is possible that numerous factors were responsible for this delay, and the degree to which reduced adherence can be ascribed in this case is unknown. Another study revealed that nonwhite patients Abbreviations: 95% CI, 95% confidence interval; AA, African American; HR, hazards ratio; P-int, P value for interaction term.…”

Section: Discussionmentioning

confidence: 93%

Lack of reduction in racial disparities in cancer‐specific mortality over a 20‐year period

Aizer

Wilhite

Chen

et al. 2014

Cancer

223

184

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BACKGROUND:To the authors' knowledge, it remains unknown whether race-based differences in cancer outcomes have changed with time. In the current study, the authors assessed whether racial disparities in cancer-specific mortality have improved over the last 20 years. METHODS: The Surveillance, Epidemiology, and End Results program was used to identify 2,713,474 patients diagnosed between 1988 and 2007 with either lung, breast, prostate, or colorectal cancer (the leading 3 causes of cancer-related mortality among each sex). After exclusions, 1,001,978 patients remained eligible for analysis. The impact of race on cancer-specific mortality was assessed using the regression model of Fine and Gray; an interaction model evaluated trends over time. RESULTS: African Americans presented with a more advanced stage of disease (P <.001) and underwent definitive therapy less often (P <.001) than whites. After adjustment for demographics and year of diagnosis, African Americans were found to have higher estimates of cancer-specific mortality than whites for all cancers combined (hazards ratio, 1.28; 95% confidence interval, 1.26-1.30 [P <.001]) and within each individual cancer (each P <.05). These differences did not change significantly between 1988 through 1997 and 1998 through 2007, except among patients with breast cancer, in whom survival disparities increased. These findings remained significant after adjustment for stage of disease at presentation and receipt of definitive therapy (hazards ratio for breast cancer mortality in African Americans vs whites: 1.37 from 1988-1997 and 1.53 from 1998-2007; P for interaction, < .001). CONCLUSIONS: The survival gap for African Americans has not closed over time. Race-based differences in outcome persist independent of stage of disease and treatment, suggesting that additional strategies beyond screening and improving access to care, such as further research into tumor biologies disproportionately affecting African Americans, are needed to improve survival for African American patients with cancer. Cancer 2014;120:1532-9.

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“…Rural men were observed to be followed less closely with repeat PSA measurements and that both the overall number and time between tests differ significantly. Fifty-one (51) men had only contrast to an American study that showed distance from treating hospital to be predictive of shorter time to surgery, 18 although our data does not specifically include information about distances from hospital. The distinction between treatment in private and public health care facilities also did not reach significance in predicting mortality in keeping with a recent Australiawide breast cancer study.…”

Section: Discussionmentioning

confidence: 93%

Rural residency and prostate cancer specific mortality: results from the Victorian Radical Prostatectomy Register

Papa

Lawrentschuk

Muller

et al. 2014

Australian and New Zealand Journal of Public Health

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While rural residency appears to affect the choice of treatment 11 or perhaps its timing, it is unknown whether rural men do worse than urban counterparts following definitive treatment for localised PCa. We sought to identify if rural residency is a risk factor for PCa specific mortality using outcomes data from the Victorian RP register (VRPR), a whole of population series of men from both urban and rural areas of Victoria who have all undergone treatment by open RP. MethodsThe VRPR is a prospective whole of population series of all men who underwent open RP for the treatment of localised prostate adenocarcinoma between 1995 and AbstractObjective: To present long-term survival data from the Victorian Radical Prostatectomy Register (VRPR), 1995-2000, and analyse the effect of rural residence on survival. Methods:Men who underwent open radical prostatectomy (RP) in Victoria from 1995 to 2000 were recorded in a population register co-ordinated by the Victorian Cancer Registry and Cancer Council Victoria. Baseline clinical, pathological and demographic information such as location were recorded and linked to mortality and recurrence data. Men who had neoadjuvant therapy or missing data for socioeconomic status (SES), tumour grade and stage were excluded leaving 1984 patients in the analyses (92.1% of total register).Results: Follow-up concluded in 2009 with 238 deaths observed, of which 77 were prostate cancer (PCa) specific. Cox and competing risk regressions were used for analysis. Living in a rural area was associated with higher odds of PCa specific mortality after RP (trend p<0.001) and a higher hazard of PCa death, the discrepancy rising up to four-fold (SHR=4.09, p=0.004) with increasing remoteness of residence. This effect is apparent after adjustment for SES, age, private or public hospital treatment, PSA level and tumour-specific factors. Conclusion:Rural men in Victoria have a shorter time to PCa death following definitive treatment, even after adjustment for SES and adverse tumour characteristics.Implication: Rural men are faring worse than their urban counterparts following the same cancer treatment.

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Socioeconomic and Clinical Factors Influence the Interval Between Positive Prostate Biopsy and Radical Prostatectomy

Cited by 16 publications

References 28 publications

Socioeconomic inequalities in prostate cancer survival: A review of the evidence and explanatory factors

Socioeconomic inequalities in prostate cancer survival: A review of the evidence and explanatory factors

Lack of reduction in racial disparities in cancer‐specific mortality over a 20‐year period

Rural residency and prostate cancer specific mortality: results from the Victorian Radical Prostatectomy Register

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