Sodium acetate ameliorated systemic and renal oxidative stress in high-fructose insulin-resistant pregnant Wistar rats

Oyabambi, Adewumi Oluwafemi; Michael, Olugbenga Samuel; Areola, Emmanuel Damilare; Saliu, Salam Babatunde; Olatunji, Lawrence Aderemi

doi:10.1007/s00210-021-02058-6

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…Impairment of antioxidant defense mechanisms like SOD is additionally a contributing element in the occurrence of oxidative harm. [43][44][45] Earlier investigations have demonstrated that NBP mitigates the deterioration of cognitive abilities induced by neuroin ammation through its inhibition in rats with diabetes. 35 Nevertheless, the previous studies have not provided a comprehensive explanation of the potential mechanisms through which NBP enhances postoperative cognitive dysfunction.…”

Section: Discussionmentioning

confidence: 99%

3-n-Butylphthalide suppresses neuroinflammation through BDNF signaling in postoperative cognitive dysfunction in mice

miao,

Zhou,

feng

et al. 2023

Preprint

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Aims: Effects of 3-n-Butylphthalide (NBP) on neuroinflammation in postoperative cognitive dysfunction (POCD) have not been well studied. This study aimed to investigate the effects of NBP treatment on surgery-induced cognitive dysfunction in mice. Methods: Male C57BL/6 mice, aged ten months, were subjected to tibialfracture surgery while under isoflurane anesthesia in order to mimic orthopedic surgery performed on humans. Tests to assess behavior were conducted at the specified time intervals. We observed structural changes in hippocampal neurons, mitochondria and Golgi apparatus by transmission electron microscopy. The expression levels of IBA1, TNF-α, IL-1β, and apoptotic proteins were determined using Western blot and ELISA. Results: The results indicated that NBP treatment ameliorates surgery-induced cognitive impairment. Moreover, NBP treatment inhibits microglial activation and reverses neuronal, mitochondrial and Golgi damage in the hippocampus of POCD mice. Furthermore, NBP decreases neuroinflammation in the hippocampus of mice with POCD. Conclusion: Our research indicates that NBP could be a promising target for therapeutic intervention in POCD.

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Section: Discussionmentioning

confidence: 99%

3-n-Butylphthalide suppresses neuroinflammation through BDNF signaling in postoperative cognitive dysfunction in mice

miao,

Zhou,

feng

et al. 2023

Preprint

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“…We need to know whether these pathological signals have common upstream regulators or downstream targets that contribute to fructose-related hypertension. Interventions or drugs based on these mechanisms, such as PRR inhibitor PRO20, 48 SCFAs acetate and butyrate, 170 allopurinol, 48 and tempol, 91 may offer benefits for patients with hypertension associated with HF intake. Thus, future clinical studies are needed to evaluate the antihypertensive action of these drugs in patients with HF/HSinduced SSH and MHF-induced PH.…”

Section: Discussionmentioning

confidence: 99%

“…167 Maternal supplementation of SCFA acetate 168 and inhibition of trimethylamine (TMA)-Noxide (TMAO) formation by maternal 3,3-dimethyl-1-butanol (DMB) treatment 168,169 significantly attenuated MHF-induced PH in adult male offspring. What's more, maternal acetate supplementation ameliorated oxidative stress in the dams 170 and their offspring, 168 as reflected by reduced plasma TMA concentrations and the ratio of TMA-to-TMAO and the enhanced renal mRNA expression of SCFA receptors in the offspring. 168 Inhibition of TMAO generation further altered gut microbiota, increased NO bioavailability, and prevented the increased renal AT1R expression but restored the decreased renal AT2R expression.…”

Section: The Imbalance Between Treg and Th17 Lymphocytes Contributes ...mentioning

confidence: 97%

Pathophysiological mechanisms of hypertension development induced by fructose consumption

2022

Food Funct.

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“…A sandwich method was used in our study in order to estimate ADA2 by the ELISA method. 16 There is a cut off value of 14.0 U/L for serum ADA2 levels. As part of the statistical analysis of the data, SPSS version 22 was used to apply an independent student t test to the data.…”

Section: Methodsmentioning

confidence: 99%

Estimation of Serum Adenosine Deaminase-2 (ADA2) as One of the Non- Invasive Diagnostic Marker of Pleural Effusion in Systemic Lupus Erythromatosus

Shah¹,

Salam²,

Ahmed³

et al. 2022

PJMHS

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Background: Systemic Lupus Erythromatosus (SLE) is an autoimmune disorder which disturbs the normal life of human due to involvement of different vital organs like bones, lungs, heart & kidney etc. A pleural effusion is one of the most common complications associated with lung involvement in young female patients with SLE. Pleural fluid examination is the main method for diagnosis, but lack of trained people and limited resources necessitate evaluating the non-invasive cheap method. Objective: To estimate the serum ADA2 level as one of non invasive marker for the diagnostic tool of pleural effusion in SLE Methodology: There were 29 female cases of SLE diagnosed in different remote areas of Pakistan divided into two groups: group-I contained 16 diagnosed cases of SLE without pulmonary involvement, and group-II contained 13 diagnosed cases of SLE with pleural effusion. The serum ADA2 level was estimated by using the ELISA method by using sandwich technology in conjunction with the ELISA method. In order to conduct the statistical analysis of the data, SPSS version 22 was used to apply an independent Student t-test. Results: The mean serum ADA2 of group-I was 15.1 ± 2.14 U/L while mean value of serum ADA2 of group-II was 11.13 ± 1.76 U/L. There was statistical (p<0.05) decreased level of serum ADA2 in patients of group-II patients with compared the patients of group-I patients. Conclusion: Serum ADA2 level in the serum may be one of diagnostic marker for the diagnosis of pleural effusion in the patients of SLE Keywords: SLE , Pleural Effusion, ADA Enzyme, ADA2,

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Sodium acetate ameliorated systemic and renal oxidative stress in high-fructose insulin-resistant pregnant Wistar rats

Cited by 6 publications

References 30 publications

3-n-Butylphthalide suppresses neuroinflammation through BDNF signaling in postoperative cognitive dysfunction in mice

3-n-Butylphthalide suppresses neuroinflammation through BDNF signaling in postoperative cognitive dysfunction in mice

Pathophysiological mechanisms of hypertension development induced by fructose consumption

Estimation of Serum Adenosine Deaminase-2 (ADA2) as One of the Non- Invasive Diagnostic Marker of Pleural Effusion in Systemic Lupus Erythromatosus

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