Sodium arsenite inhibits migration of extravillous trophoblast cells in vitro

Li, Chi Shan; Loch‐Caruso, Rita

doi:10.1016/j.reprotox.2007.06.002

Cited by 11 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides the generation of oxidative stress as a possible mechanism by which As may be associated with PE, Shin Le et al reported that exposure to environmentally relevant concentrations of As (2.5 μM of AsNaO2) inhibit the migration of EVT cells (a human extravillous trophoblast cell line) in vitro, therefore, a similar mechanism may be occurring in vivo [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Arsenic exposure and risk of preeclampsia in a Mexican mestizo population

Sandoval-Carrillo

Méndez-Hernández

Antuna-Salcido

et al. 2016

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

BackgroundExposure to arsenic in drinking water has been associated with various complications of pregnancy including fetal loss, low birth weight, anemia, gestational diabetes and spontaneous abortion. However, to date, there are no studies evaluating its possible association with preeclampsia.MethodsThis case–control study involved 104 preeclamptic and 202 healthy pregnant women. The concentrations of arsenic in drinking water and urine were measured using a Microwave Plasma-Atomic Emission Spectrometer.ResultsWe found relatively low levels of arsenic in household tap water (range of 2.48–76.02 μg/L) and in the urine of the participants (7.1 μg/L vs 6.78 μg/L in cases and controls, respectively).ConclusionsThe analysis between groups showed for the first time that at these lower levels of exposure there is no association with preeclampsia.

show abstract

Section: Introductionmentioning

confidence: 99%

Arsenic exposure and risk of preeclampsia in a Mexican mestizo population

Sandoval-Carrillo

Méndez-Hernández

Antuna-Salcido

et al. 2016

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

show abstract

“…Birth defects reported involve neural tube defects, coarction of the aorta, and midfacial cleft (Aggarwal et al, 2007;Hill et al, 2008). At a cellular level, arsenic can disturb cellular differentiation and migration (Li and Loch-Caruso, 2007;Trouba et al, 2000;Yancy et al, 2005).…”

mentioning

confidence: 99%

Arsenic Exposure Perturbs Epithelial-Mesenchymal Cell Transition and Gene Expression In a Collagen Gel Assay

Lencinas

Broka

Konieczka

et al. 2010

Toxicological Sciences

View full text Add to dashboard Cite

Arsenic is a naturally occurring metalloid and environmental contaminant. Arsenic exposure in drinking water is reported to cause cancer of the liver, kidneys, lung, bladder, and skin as well as birth defects, including neural tube, facial, and vasculogenic defects. The early embryonic period most sensitive to arsenic includes a variety of cellular processes. One key cellular process is epithelial-mesenchymal transition (EMT) where epithelial sheets develop into three-dimensional structures. An embryonic prototype of EMT is found in the atrioventricular (AV) canal of the developing heart, where endothelia differentiate to form heart valves. Effects of arsenic on this cellular process were examined by collagen gel invasion assay (EMT assay) using explanted AV canals from chicken embryo hearts. AV canals treated with 12.5-500 ppb arsenic showed a loss of mesenchyme at 12.5 ppb, and mesenchyme formation was completely inhibited at 500 ppb. Altered gene expression in arsenic-treated explants was investigated by microarray analysis. Genes whose expression was altered consistently at exposure levels of 10, 25, and 100 ppb were identified, and results showed that 25 ppb in vitro was particularly effective. Three hundred and eighty two genes were significantly altered at this exposure level. Cytoscape analysis of the microarray data using the chicken interactome identified four clusters of altered genes based on published relationships and pathways. This analysis identified cytoskeleton and cell adhesion-related genes whose disruption is consistent with an altered ability to undergo EMT. These studies show that EMT is sensitive to arsenic and that an interactome-based approach can be useful in identifying targets.

show abstract