Soft‐tissue Calcification Induced by Rare Earth Metals and Its Prevention by Sodium Pyrophosphate

Gabbiani, Giulio; Jacqmin, M. L.; Richard, Roger-Bruno

doi:10.1111/j.1476-5381.1966.tb01636.x

Cited by 31 publications

(8 citation statements)

References 15 publications

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“…This observation may be related to our findings showing that high doses of CeCl3 and HoClk cause either no change or a decrease of serum calcium and phosphate, while small amounts induce an increase of both electrolytes. In high doses, the rare earth metals are absorbed in the reticulo-endothelial system (Haley, 1965) and induce accumulation of calcium salts in the spleen (Gabbiani et al, 1966). It seems probable that the hypocalcaemia and hypophosj~hataemia which follow intravenous administration of high amounts of rare earth metals result from the accumulation of calcium salts in the spleen, because the two phenomena occur almost simultaneously.…”

Section: Discussionmentioning

confidence: 99%

Action of Various Metallic Chlorides on Calcaemia and Phosphataemia

Johannsson

Perrault

Savoie

et al. 1968

British Journal of Pharmacology and Chemotherapy

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Section: Discussionmentioning

confidence: 99%

Action of Various Metallic Chlorides on Calcaemia and Phosphataemia

Johannsson

Perrault

Savoie

et al. 1968

British Journal of Pharmacology and Chemotherapy

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“…Among these, the salts of lead and of rare earth metals are especially potent. The intravenous administration of several calcergens increases the levels of blood calcium and phosphorus (KuMAGXI and SAXAI, 1966;JOHA~NSSON et al, 1968), and so prepares the animals that trauma, or compounds which increase capillary permeability (e.g., histamine liberators, histamine, 5-HT), produce precipitation of calcium salts at the site of their application (S~LY~, et al, 1962;GABBIANI et al, 1966;S~LYE et aI., 1964b;S~,LYV. et al, 1964c;GAB~IAI~I and TIICH-W~,B~,R, 1965).…”

Section: Introductionmentioning

confidence: 96%

“…The conditioner is always given systemically and the reaction form is designated as local or systemic, depending upon whether the challenger responsible for the localization of the lesions reaches the target area by direct topical application or through the blood stream (SELYE, 1962;S~LY~ et al, 1964a). Caleergy is a calcinosis, produced without any previous conditioning, by the parenteral administration of certain direct calcifying agents (mostly metallic salts) which are called calcergens (S~,LY~, 1962;S~,LY~ et al, 1962;GABBIANI et al, 1966). Among these, the salts of lead and of rare earth metals are especially potent.…”

Section: Introductionmentioning

confidence: 98%

Inhibition of local calcergy by topical application of calciphylactic challengers

1968

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Experiments on rats indicate that, with very few exceptions, the calcification which occurs at subcutaneous sites of treatment with lead acetate, cerium chloride, calcium chloride or potassium permanganate is completely blocked or severely inhibited by simultaneous topical application of calciphylaetic challengers but not of non-challengers. Despite the few exceptions (which are thought to depend upon specific chemical interactions between some of the compounds tested) this singular correlation between calciphylactic challenging and anticalcergic potency, is highly significant by the Chi-square-test (P< 0.001).Key words: Calcergy --Calciphylaxis ~ Calcium --Metals.Chez le rat, des experiences ont montr6 que, saul de rares exceptions, les calcifications produites au site d'injeetion d'ac6tate de plomb, de chlorure de c6rinm, chlorure de calcium ou de permanganate de potassium sent compl~tement pr6venues ou fortement inhib6es par l'application locale simultan6e de provocageurs calciphylactiques, mais non par des agents non provocateurs. Malgr6 quelques exceptions (attribu6es ~ des interrelations chimiques sp6cifiques entre certaines des substances utilis6es), cette curieuse corr61ation entre l'efficacit~ calciphylactique provocatrice et le pouvoir anticalcergique est, d'apr~s le test gs, hautement significative (P < 0,001).Nach subcutaner Injektion yon Bleiacetat, Ceriumchlorid, Calciumchlorid oder Kaliumpermanganat tritt an der Injektionsste]le eine starke Verkalkung auf. Bis auf sehr wenige Ausnahmen kann diese durch gleichzeitige lokale Anwendung yon calciphylaktischen Provokatoren verhfitet oder weitgehend unterdriickt werden. In dieser Beziehung sind nicht provolatorisch wirkende Stoffe inaktiv. Trotz der wenigen Ausnahmen (die wahrscheinlich auf spezifische, chemische Wechselwirkungen zwischen manchen der untersuchten Substanzen beruhen) ist dieser merkwiirdige Zusammenhang zwischen calciphylaktisch provozierender und anticalcergischer Aktivit~t, nach dem g2-Test berechnet, statistisch hochsignifikant (P< 0,001).

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“…Haley and Upham (1963) have also demonstrated calcium salts in granulomas induced by the intradermal injection of several lanthanides in the guinea-pig. Gabbiani, Jacqmin and Richard (1966) showed that lanthanides (radioactive promethium was not tested) were capable of inducing local calcergy in the rat and that this calcergenic reactivity was inhibited by simultaneous treatment with sodium pyrophosphate.…”

mentioning

confidence: 99%

Lanthanide‐induced calcergy

Garrett

McClure

1981

The Journal of Pathology

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The subcutaneous injection of solutions of chloride salts of the rare earths is followed by calcification of the dorsal fascia in the mouse. The concentration of salt required to produce a constant, predictable response varies from salt to salt. The macroscopic outline of the reaction is generally irregular and therefore a quantitative radiological method has been developed to allow an accurate assessment of the dose/response relationship. This with the majority of salts is best described as a log regression and with three as a linear regression.

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Soft‐tissue Calcification Induced by Rare Earth Metals and Its Prevention by Sodium Pyrophosphate

Cited by 31 publications

References 15 publications

Action of Various Metallic Chlorides on Calcaemia and Phosphataemia

Action of Various Metallic Chlorides on Calcaemia and Phosphataemia

Inhibition of local calcergy by topical application of calciphylactic challengers

Lanthanide‐induced calcergy

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